All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”
EN
ČeštinaEnglish

Filters

29 (0,136s) •

Project

Biodegradable high-molecular-weight HPMA copolymers prepared by controlled radical RAFT polymerisation (GPP207/11/P551)

Copolymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) have been studied that biodegradable high-molecular-weight HPMA polymer conjugates with doxorubicine exhibited considerable anticancer activity against solid tumours. Unti...

CD - Makromolekulární chemie

  • 2011 - 2014
    • •
  • 1 920 tis. Kč
    • •
  • 1 920 tis. Kč
    • •
  • GA ČR
Project

Changes in surface saccharides in cells exposed to HPMA-based therapeutics. (GP305/07/P172)

Conjugation of the routinely used anticancer drug doxorubicin to N-(2-hydroxypropyl)methacrylamide (HPMA) carrier by hydro- or aminolytic bonds strongly reduces hydrolytically released from HPMA conjugate - intercalates into nuclear...

EC - Imunologie

  • 2007 - 2009
    • •
  • 1 494 tis. Kč
    • •
  • 1 494 tis. Kč
    • •
  • GA ČR
Project

Application of polymer donors of nitric oxide for enhanced accumulation of cytostatics and immunomodulators in the solid tumor microenvironment (GA14-12742S)

)methacrylamide (HPMA)-based polymer conjugates will be prepared as a tool for tumor-specific (NO) donor bound to HPMA-based polymer carrier via a defined covalent linkage. NO has......

CD - Makromolekulární chemie

  • 2014 - 2018
    • •
  • 7 398 tis. Kč
    • •
  • 7 398 tis. Kč
    • •
  • GA ČR
Project

Polymeric drugs actively targeted by recombinant antibody fragments as therapeutic approach in treatment of GD2 positive cancers (GA16-17207S)

The aim of the project is development of novel polymeric therapeutics, based on HPMA copolymers bearing cytostatic drugs (e.g. doxorubicin) and actively targeted by recombinant antibody fragments against GD2 positive tumors. The effect of di...

CD - Makromolekulární chemie

  • 2016 - 2018
    • •
  • 9 495 tis. Kč
    • •
  • 8 239 tis. Kč
    • •
  • GA ČR
Project

Depletion of T regulatory cells without need of anti-CD25 mAb for effective chemoimmunotherapy by HPMA-based polymeric drugs and IL-2 immunocomplexes (GAP301/11/0325)

the chemoimmunotherapy with new generation of dendrimeric HPMA-based polymeric drugs in combination...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 17 039 tis. Kč
    • •
  • 17 039 tis. Kč
    • •
  • GA ČR
Project

Spherical „horse in vacuum“ or applicable micelles? Behavior and shape of nanoparticles – anticancer drug carriers in real blood environment. (GC15-10527J)

-hydroxypropyl) methacrylamide (HPMA) copolymers bearing defined amounts of cholesterol methods SANS/SAXS/ASAXS together with FCS/FLIM we will develop the model of HPMA......

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2018
    • •
  • 5 751 tis. Kč
    • •
  • 5 751 tis. Kč
    • •
  • GA ČR
Project

Overcoming P-glycoprotein-mediated multidrug resistance (MDR) (GA310/99/P020)

conjugated to polymeric carrier based on N-(2-hydroxypropyl)methacrylamide (HPMA). Doxorubicin conjugated to HPMA has entered Phase II. clinical trial in UK, galactosamine......

EC - Imunologie

  • 1999 - 2001
    • •
  • 792 tis. Kč
    • •
  • 719 tis. Kč
    • •
  • GA ČR
Project

THE EFFECT OF HPMA DRUG BASED THERAPY ON THE LOCAL TUMOR MICROENVIRONMENT (IAA400200702)

Polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide bearing doxorubicin were developed as a system designed to improve the therapeutic index of cytostatic drugs and eliminate their side effects. There are many types of conjugates, which d...

CD - Makromolekulární chemie

  • 2007 - 2011
    • •
  • 5 878 tis. Kč
    • •
  • 5 878 tis. Kč
    • •
  • AV ČR
Project

Potentiation of anti-tumor immunity with cytokine immnocomplexes during treatment with polymer-bound drugs (GP301/07/P192)

N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers containing the anticancer drug doxorubicin are passively accumulated in solid tumors due to the EPR effect. Moreover, if such conjugates contain specific targeting moiety, they can be activ...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 1 464 tis. Kč
    • •
  • 1 464 tis. Kč
    • •
  • GA ČR
Project

Chemo-immunotherapy with immunopolymers based on N-(2-hydroxypropyl)methacrylamide;mechanisms of action (GA305/05/2268)

Water-soluble polymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) háve been developed as drug carriers to improve the therapeutic index of a variety of anti-tumor agents and the immunosuppressive drug cyclosporine A. Experimental have...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 4 965 tis. Kč
    • •
  • 4 965 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 29