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16 (0,121s) •

Project

Vaccination against two types (MHC I+ and MHC I-) of tumours induced by E6/E7 HPV16 viral oncogenes. (NC7148)

This grant project is aimed at optimization of the immunotherapeutic protocols in two types of tumours (MHC I+ and MHC I-) induced by HPV16 E6/E7 oncogenes projectby insertion of IL-2 and GM-CSF genes into HPV16+ tumour cells The re...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 5 395 tis. Kč
    • •
  • 3 375 tis. Kč
    • •
  • MZ
Project

Expression of papillomavirus antigenic epitopes in plants using plant viral vector (GA521/06/0973)

The aim of the proposed project is to prepare protein antigens derived from human papilloma virus HPV16 and to optimize their expression in plants for the purpose of developing experimental anti-HPV16 vaccines. We propose the produc...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 3 909 tis. Kč
    • •
  • 3 909 tis. Kč
    • •
  • GA ČR
Project

Vectors for gene therapy targeted on stromal cells of solid tumors (NR9238)

Investigation of an anti-tumor therapeutic DNA vaccine and vectors for gene therapy targeting tumor fibroblasts in mouse model of tumors induced by papilloma virus HPV16. DNA vaccine will provide immunization against fibroblast activating

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 9 764 tis. Kč
    • •
  • 9 542 tis. Kč
    • •
  • MZ
Project

Induction of immunity against HPV16 E6/E7 oncogenes-induced tumours with peptide- and dendritic cell-based vaccines; immunotherapy of minimal residual tumour disease. (IAA500520605)

This project is focused on the analysis of the differences in the effectiveness of the antigen presentation by dendritic cells in healthy, tumour-bearing and surgically treated animals. Peptide-loaded dendritic cells will be used for immunotherapy of...

EC - Imunologie

  • 2006 - 2009
    • •
  • 3 329 tis. Kč
    • •
  • 3 329 tis. Kč
    • •
  • AV ČR
Project

Biosafe plant virus expression system for transient production of human papillomavirus oncoproteins and their use for therapeutic vaccine development (GA521/09/1525)

 The aim of the proposed project is to prepare protein immunogens derived from human papillomavirus HPV16 and optimization of their expression in plants for developing experimental therapeutic anti-HPV16 vaccines. We propose the pro...

EI - Biotechnologie a bionika

  • 2009 - 2011
    • •
  • 4 792 tis. Kč
    • •
  • 4 792 tis. Kč
    • •
  • GA ČR
Project

Combined therapy of metastazising tumours induced by HPV 16 E8/E7 and ras oncogenes (GA301/01/0985)

The proposed project is aimed at the therapy of murine tumours induced by the aetiological agent of human cervical carcinoma, HPV16, resp. by the E6/E7 oncogenes of this virus. Another aim is to study the effect of therapy of the subcutaneou...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 5 402 tis. Kč
    • •
  • 4 545 tis. Kč
    • •
  • GA ČR
Project

Combined Immunotherapy of Tumours Induced by Human Papillomavirus (NR8004)

The aim of the project is to develop an immunotherapeutic procedure against papilloma virus-associated tumours employing prime/boost strategy. The approach combines heterologous vaccines. They include DNA vaccines, recombinant vaccinia viruses or den...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 13 021 tis. Kč
    • •
  • 10 895 tis. Kč
    • •
  • MZ
Project

Immunosuppressive cell populations in the course of tumour progression and therapy. (GA301/07/1410)

, immature myeloid cells and NKT cells, using the murine model for HPV16-associated...

FD - Onkologie a hematologie

  • 2007 - 2011
    • •
  • 8 875 tis. Kč
    • •
  • 8 875 tis. Kč
    • •
  • GA ČR
Project

Development of anti-tumor DNA vaccines based on fusion of immunogen with E. coli beta-glucuronidase and enhancement of their effect by stimulation of non-specific immunity (NR9246)

Enhancement of efficacy of therapeutic anti-tumor vaccines based on fusion of a tumor antigen with E. coli beta-glucuronidase. Increase of production of immunogens (oncoproteins E7 and E6 of HPV16 and fusion oncoprotein Bcr-Abl) by modificat...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 8 294 tis. Kč
    • •
  • 8 104 tis. Kč
    • •
  • MZ
Project

Gene immunotherapy of tumours with different expression of MHC-I. (NC5900)

Induction of immunity against tumours cells producing HPV16 E7 oncoprotein and differing in the degree of MHC-I expression.Combination of DNA immunization and immunization with transduced tumour cells. Enhancement of immune responses by heat...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 9 325 tis. Kč
    • •
  • 8 670 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 16