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5 420 (0,098s) •

Project

Towards molecular separation of metabolic and mitogenic effects of insulin and IGF-2 (GA15-19018S)

Insulin and IGF-2 are related hormones that control key aspects of metabolism and growth in tissues. Although insulin and IGF-2 have distinct physiological roles of IR-A and IGF-1R and increases autocrine ...

CE - Biochemie

  • 2015 - 2017
    • •
  • 6 705 tis. Kč
    • •
  • 6 705 tis. Kč
    • •
  • GA ČR
Project

Prospective study of factors influencing postnatal growth and factors that constitute risk of certain diseases in adulhood in children born small for gestational age and in children with extremely low birth weight (NR9374)

Increased risk of diabetes mellitus 2 (DM 2) and cardiovascular diseases (CVD) is associated with low birth weight and low IGF-I levels. Some polymorphism of IGF-I gene correlates with IGF-I levels, decrea...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 8 692 tis. Kč
    • •
  • 8 656 tis. Kč
    • •
  • MZ
Project

Analogues of insulin, IGF-1 and IGF-2 to study their neuroprotective effects in neurons and glial cells. (GA22-17978S)

. Broader knowledge of possible positive influence of insulin, IGF-1 or IGF-2 therapies basal and neuroprotective effects of several unique insulin, IGF-1 and IGF-2......

Cell biology

  • 2022 - 2024
    • •
  • 9 928 tis. Kč
    • •
  • 9 017 tis. Kč
    • •
  • GA ČR
Project

The structure-activity study of peptides derived from pro-IGF2 playing a role in the pathogenesis of cancer, type 2 diabetes and osteoporosis. (GA19-14069S)

Insulin and closely related Insulin-like Growth Factors 1 and 2 (IGF-1 and 2, survival, differentiation (IGFs), and life span (insulin and IGFs). Dysregulation of their signaling leads to diabetes and canc...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 826 tis. Kč
    • •
  • 8 394 tis. Kč
    • •
  • GA ČR
Project

Improvement of the diagnostics of disorders of growth hormone secretion with the follow- up of growth hormone binding protein and IGF-binding protein 3 (IZ2344)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1994 - 1997
    • •
  • 589 tis. Kč
    • •
  • 706 tis. Kč
    • •
  • MZ
Project

Electrophoresis and Western Blotting of IGF I Binding Preoteins in Disorders of the Growth Hormone -IGF-I Axis. (IZ3661)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1996 - 1998
    • •
  • 1 489 tis. Kč
    • •
  • 1 399 tis. Kč
    • •
  • MZ
Project

Binding proteins of IGF in hypopituitary patients treated with growth hormone. (NB5458)

IGF I binding proteins, Western Blotting, fragmentation, therapy with growth hormone. The examination of IGF I binding proteins including their low and high molecular forms and proteolytic fragments will contribute to the improvemen...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1999 - 2001
    • •
  • 1 914 tis. Kč
    • •
  • 1 914 tis. Kč
    • •
  • MZ
Project

Peptides from the Intrachinary Regions of Insulin, IGF I, IGF II. Synthesis, Physiochemical and Biological Properties (GA505/93/2140)

GM - Potravinářství

  • 1993 - 1995
    • •
  • 286 tis. Kč
    • •
  • 572 tis. Kč
    • •
  • GA ČR
Project

Endocrine function of adipose tissue in the etiopathogenesis of the gestational diabetes. (NV15-27630A)

, they are at increased risk for development of obesity, diabetes type 2 and cardiovascular factor for developing type 2 diabetes later in life. Despite of worldwide increasing diabetes is similar in many ways to diabetes type 2...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 8 455 tis. Kč
    • •
  • 8 455 tis. Kč
    • •
  • MZ
Project

Comparation study of the serum and tissue cytokines level before and after parathyroidectomy for parathyroid adenoma and hyperplastic parathyroid glands (NK6023)

Comparasion serum and tissue TGF alpha,bFGF,IGF,IGF-I and TNF alpha and IL-6 before and after parathyroidectomy for parathyroid adenoma and hyperplastic parathyroid gland.......

FF - ORL, oftalmologie, stomatologie

  • 2000 - 2002
    • •
  • 2 597 tis. Kč
    • •
  • 2 597 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 5 420