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5 496 (0,113s) •

Project

Complexes of IL-2 and anti-IL-2 mAb with selective stimulatory activity for CD25+ T cells in cancer immunotherapy changing the paradigm (GA22-20548S)

Complexes of IL-2 and anti-IL-2 mAbs possess extremely high biological activity in vivo. Moreover, such IL-2 complexes have selective stimulatory activity for different IL-2 resp...

Oncology

  • 2022 - 2024
    • •
  • 8 330 tis. Kč
    • •
  • 8 330 tis. Kč
    • •
  • GA ČR
Project

Strong sustained IL-2 signal selectively targeted to CD25+ cells dramatically increases sensitivity to LPS-mediated mortality finding the mechanism (GA13-12885S)

It has been shown previously that complexing IL-2 with certain anti-IL-2 mAb enourmously increases activity of IL-2 in vivo. These immunocomplexes selectively stimulate different subsets of immune...

EC - Imunologie

  • 2013 - 2018
    • •
  • 11 872 tis. Kč
    • •
  • 11 872 tis. Kč
    • •
  • GA ČR
Project

IL-2 complexed with muteins of JES6-1 mAb having different affinity to IL-2 finding variant with most selective stimulation of Treg cells in vivo (GA18-12973S)

Complexes of IL-2 and anti-IL-2 mAb JES6-1 potently expand CD25+ cells, i.e to understanding the mechanism how these complexes interact with high affinity trimeric IL-2 receptor. JES6-1 mAb steric...

Immunology

  • 2018 - 2022
    • •
  • 4 804 tis. Kč
    • •
  • 4 762 tis. Kč
    • •
  • GA ČR
Project

Distinct roles of IL-2 for antigen-primed CD8+ and CD4+ T cells a paradigm shift in T cell biology and implication for cancer immunotherapy (GA25-16348S)

Current immunology considers the IL-2 to be equally important for activated CD8 that IL-2 is a crucial cytokine for proliferation and survival of all antigen-primed T cells. Our objective is to prove that IL

Immunology

  • 2025 - 2027
    • •
  • 8 997 tis. Kč
    • •
  • 8 997 tis. Kč
    • •
  • GA ČR
Project

Analysis of intracellular IL-1RA isoforms in patients with juvenile idiopathic arthritis and their relation to clinical features of the disease (NR7922)

and IL-1RN*1/1, IL-1RN*1/2 a IL-1RN*2/2 genotypes in JIA patients and controlsDifferentiation of production of IL-1RA izoforms in cell populations in peripheral blood/synovial tissue of ...

FG - Pediatrie

  • 2004 - 2006
    • •
  • 5 022 tis. Kč
    • •
  • 4 826 tis. Kč
    • •
  • MZ
Project

Predictive immunological markers in patients with hepatitis C viral infection (NT14072)

in laboratory in Prague using FlowCytomix methodology: IL-1b, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IFNg, TGF-b and TNF? and 4) Next imunological markers will be assessed the in...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2013 - 2015
    • •
  • 7 567 tis. Kč
    • •
  • 7 567 tis. Kč
    • •
  • MZ
Project

Novel clinically relevant IL-2 immunotherapeutics for cancer treatment (GA20-13029S)

Mouse IL-2/S4B6 mAb complexes with potent stimulatory activity for memory CD8 IL-2. Potential clinical use of these complexes is limited due to the mouse origin of IL-2 and dissociation of the com...

Immunology

  • 2020 - 2022
    • •
  • 12 596 tis. Kč
    • •
  • 12 596 tis. Kč
    • •
  • GA ČR
Project

PRODUCTION OF RECOMBINANT IMMUNOCYTOKINES FOR TUMOR IMMUNOTHERAPY (IAA500200712)

Effective cancer theraphy through immunomodulation is one of the most important long-term goal of imunology. Although IL-2 and IL-12, one of the most promising and IL-2 has been already approved by FDA for...

EC - Imunologie

  • 2007 - 2011
    • •
  • 4 725 tis. Kč
    • •
  • 4 725 tis. Kč
    • •
  • AV ČR
Project

Activation of HIV-Specific CD8+ T Lymphocytes by IL-2 and Histamine Possible Use in Therapy? (NR9032)

after incubation with the Histamine, IL-2: their count, production of Perforin their functional activation. IL-2 induces maturation of HIV-specific CD8+ T lymphocytes. We a synergistic effects of Histamine and

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2006 - 2008
    • •
  • 2 200 tis. Kč
    • •
  • 2 200 tis. Kč
    • •
  • MZ
Project

Immunogenetics of lung inflammation VNTR polymorphims of IL-1RA (IL-1 receptor antagonist) gene and pulmonary fibrosis (idiopathic, secondary) (GA310/99/1676)

is to investigate if allele 2 of IL-1RA gene determines an "immunological phenotype" leadingtoInterleukin-1 (IL-1), which is blocked by its natural antagonist (IL-1RA associated with rheumatological disease we wis...

EC - Imunologie

  • 1999 - 2001
    • •
  • 597 tis. Kč
    • •
  • 597 tis. Kč
    • •
  • GA ČR
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