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398 (0,09s) •

Project

Lymphocyte subpopulatins in patients with humoral immunodeficiencies (NR7981)

T- and- B- cell surface markers, namely those known to be abnormal in patients with common variable immunodeficiency (CVID), will be analysed in patients with selective IgA deficiency, selective IgM deficiency and CVID. The...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2004 - 2006
    • •
  • 1 682 tis. Kč
    • •
  • 1 668 tis. Kč
    • •
  • MZ
Project

The study of the relation between Epstein-Barr virus infection and development of IgA nephropathy (NV15-33686A)

cells with a potential to differentiate into IgA-producing plasma cells secrete galactose-deficient IgA1 molecules which serve as an antigen recognized by ubiquitous antibodies specific galactose-deficient molecule. To exa...

EC - Imunologie

  • 2015 - 2018
    • •
  • 6 427 tis. Kč
    • •
  • 6 427 tis. Kč
    • •
  • MZ
Project

Study of IgA1 glycosylation in IgA nephropathy (GAP302/10/1055)

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis by the predominant deposition of IgA in the glomerular mesangium. This IgA is predominantly polymeric IgA1 with aberrantly glycosylated, galactose...

EC - Imunologie

  • 2010 - 2013
    • •
  • 4 882 tis. Kč
    • •
  • 4 882 tis. Kč
    • •
  • GA ČR
Project

Significance of TACI mutations and lymphocyte subpopulations in pathogenesis of selective IgA deficiency (NS10398)

The project is focused on selective IgA deficiency (IgAD). The frequency of TACI mutations will be determined in IgAD patients and in a healthy Czech population. Although the TACI mutations were shown to be increased in patients wit...

EC - Imunologie

  • 2009 - 2011
    • •
  • 3 035 tis. Kč
    • •
  • 3 035 tis. Kč
    • •
  • MZ
Project

Immunoregulatory defects in patients with humoral immunodeficiencies (NI4703)

The goal of the study is to determine the frequency of IgA deficiency (IgAD) in general population and in patients with immunopathological diseases and to investigate possible etiopathological relations between IgAD and common varia...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1998 - 2000
    • •
  • 2 352 tis. Kč
    • •
  • 2 166 tis. Kč
    • •
  • MZ
Project

Fc receptors on immune cells and clinical manifestation in patients with primary immunodeficiency (NI7138)

The relation of membrane structures, particularly Fc gamma receptors to the severity of clinical manifestation and to the efficacy of gammaglobulin therapy in patients with primary immunodeficiency will be analysed in the study. A part of the study i...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2002 - 2004
    • •
  • 2 881 tis. Kč
    • •
  • 2 841 tis. Kč
    • •
  • MZ
Project

Innate-glycan-mediated and specific IgA-dependent protection in bacterial intestinal infection of experimental animals (GA17-11275S)

Gut mucosa is colonized by diverse commensal bacteria coated with IgA antibodies. In addition to the antigen-specific interaction, the binding of IgA component (SC) of secretory IgA (S-IgA). As the analogous glycan...

EC - Imunologie

  • 2017 - 2021
    • •
  • 9 518 tis. Kč
    • •
  • 9 352 tis. Kč
    • •
  • GA ČR
Project

Disturbances of differentiation of B-lymphocytes in patients with defects of humoral immunity (NT11414)

The Ig-specific single-cell RT-PCR in B cells of patients with CVID, IgAD/IgMD will be used to analyze somatic hypermutation, affinity maturation/isotype switch, proliferation and activation, BCR signalling and differentiation stadium of B cell subse...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2010 - 2014
    • •
  • 9 894 tis. Kč
    • •
  • 9 894 tis. Kč
    • •
  • MZ
Project

The expression of proinflammatory genes in patients with IgA nephropathy and their relation to the disease outcome (NR8913)

Determine correlation among intrarenal expression of MCP-1, RANTES, TGF-beta1, HGF and BMP genes, infiltration of leukocyte into renal tissue, proteinuria and short term otcome of IgA nephropathy. Find out if patients with genotype related a...

FE - Ostatní obory vnitřního lékařství

  • 2006 - 2009
    • •
  • 4 966 tis. Kč
    • •
  • 4 432 tis. Kč
    • •
  • MZ
Project

Factors affecting the course of IgA nephropathy – the most common primary glomerulonephritis. (LH15168)

We propose to develop noninvasive diagnostic tests for detection of subclinical types of IgA nephropathy, evaluation of disease activity, and assessment of treatment effectiveness. Consequently, these tests will allow to avoid repeat renal b...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 1 896 tis. Kč
    • •
  • 1 896 tis. Kč
    • •
  • MŠMT
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