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93 (0,235s) •

Project

The expression of proinflammatory genes in patients with IgA nephropathy and their relation to the disease outcome (NR8913)

Determine correlation among intrarenal expression of MCP-1, RANTES, TGF-beta1, HGF and BMP genes, infiltration of leukocyte into renal tissue, proteinuria and short term otcome of IgA nephropathy. Find out if patients with genotype ...

FE - Ostatní obory vnitřního lékařství

  • 2006 - 2009
    • •
  • 4 966 tis. Kč
    • •
  • 4 432 tis. Kč
    • •
  • MZ
Project

Factors affecting the course of IgA nephropathy – the most common primary glomerulonephritis. (LH15168)

We propose to develop noninvasive diagnostic tests for detection of subclinical types of IgA nephropathy, evaluation of disease activity, and assessment of treatment effectiveness. Consequently, these tests will allow to avoid repea...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 1 896 tis. Kč
    • •
  • 1 896 tis. Kč
    • •
  • MŠMT
Project

New mode of treatment of IgA nephropathy and the ways of monitoring (IZ4216)

The evaluation of the role of prostanoids in treatment of IgA nephropathy using fish oil is the main target of the project.During the one year s treatment with fish oil levels of prostanoids and cytokines will be monitored.......

FE - Ostatní obory vnitřního lékařství

  • 1997 - 1999
    • •
  • 1 841 tis. Kč
    • •
  • 1 620 tis. Kč
    • •
  • MZ
Project

The study of interactions among IgA1-glycosylating enzymes in IgA nephropathy (LH11046)

Abnormalities in immunoglobulin A1 (IgA1) O-linked glycosylation belong to the initial cause of IgA nephropathy. Several enzymes-glycosyltransferases (GTs) namely ST6GalNAcII, C1GalT1, C1GalT2, and GalNAcT2 contribute in IgA1 O-glyc...

EC - Imunologie

  • 2011 - 2014
    • •
  • 1 822 tis. Kč
    • •
  • 1 822 tis. Kč
    • •
  • MŠMT
Project

The influence of gene polymorphisms on the progression of autosomal dominant polycystic kidney disease and IgA nephropathy (NK7733)

The aim of the project is the proof of relation between presence of arterial hypertension and progression of selected chronic renal diseases into the end stage renal failure and some gene polymorphisms supposed to be included in pathogenesis.......

FP - Ostatní lékařské obory

  • 2003 - 2005
    • •
  • 2 175 tis. Kč
    • •
  • 2 173 tis. Kč
    • •
  • MZ
Project

The study of the relation between Epstein-Barr virus infection and development of IgA nephropathy (NV15-33686A)

Immunoglobulin A nephropathy (IgAN) is autoimmune disease without known triggers contributing to clinical manifestation. In this application we propose that Epstein-Barr virus infection could be involved in initiation of IgAN - EBV-infected ...

EC - Imunologie

  • 2015 - 2018
    • •
  • 6 427 tis. Kč
    • •
  • 6 427 tis. Kč
    • •
  • MZ
Project

Molecular approaches for elimination or inactivation of pathogenic circulating immune complexes in IgA nephropathy and Henoch-Schoenlein purpura. (NT11081)

In this grant proposal the properties of high molecular weight immune complexes isolated from IgA nephropathy (IgAN) and Henoch-Schoenlein purpura nephritis (HSPN) patients? sera will be analyzed. They are main etiopathological fact...

FP - Ostatní lékařské obory

  • 2010 - 2014
    • •
  • 9 132 tis. Kč
    • •
  • 9 132 tis. Kč
    • •
  • MZ
Project

Study of IgA1 glycosylation in IgA nephropathy (GAP302/10/1055)

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis with about 20%?40% patients developing end-stage renal disease. IgAN is defined by the predominant deposition of IgA in the glomerular mesangium. ...

EC - Imunologie

  • 2010 - 2013
    • •
  • 4 882 tis. Kč
    • •
  • 4 882 tis. Kč
    • •
  • GA ČR
Project

Oxidant stress in the pathogenesis of glomerulonephritis (NK6623)

Aim of the proposed study is to examine urinary excretion (and plasmy levels) of 8-isoprostane (a marker of the oxidant stress) in patients with various types of glomerulonephritides and in patients with chronic renal failure.......

FP - Ostatní lékařské obory

  • 2001 - 2003
    • •
  • 1 804 tis. Kč
    • •
  • 1 804 tis. Kč
    • •
  • MZ
Project

Human urinary exosomes - the source of new biomarkers for the diagnosis and follow-up of kidney diseases (NV15-31662A)

The project will study new diagnostic and predictive biomarkers in urinary exosomes in patients with immune-based kidney diseases (lupus nephrititis and ANCA-associated vasculitis) and IgA nephropathy, Urinary exosomes contain prote...

FE - Ostatní obory vnitřního lékařství

  • 2015 - 2019
    • •
  • 7 500 tis. Kč
    • •
  • 7 441 tis. Kč
    • •
  • MZ
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