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1 133 (0,124s) •

Project

Analysis of clonal heterogeneity in chronic lymphocytic leukemia using next generation sequencing of B cell receptor. A national study. (NV15-30015A)

of B lymphocytes, each case can be described by a specific immunoglobulin gene (IG) encoding for the B cell receptor. Extensive molecular evidence was provided on antigen-throughput sequence analysis has not been applied extensivel...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 15 351 tis. Kč
    • •
  • 15 028 tis. Kč
    • •
  • MZ
Project

The development and standardization of method for analysis of antigen receptor gene rearrangements using next generation sequencing for use in immunoh (NV16-32568A)

Next generation sequencing (NGS) has opened a unique possibility to sequence all rearrangements of immunoglobulin (Ig) and T-cell receptor (TR) genes on the usefulness of NGS Ig/TR detection for the assessment of minimal re...

EC - Imunologie

  • 2016 - 2019
    • •
  • 9 663 tis. Kč
    • •
  • 9 663 tis. Kč
    • •
  • MZ
Project

The role of tetraspanin CD53 in mast cell biology (GA20-16481S)

Tetraspanins play an important role in immune cell function by influencing the activity of various cell surface receptors. CD53 is a pan-leukocyte tetraspanin, which has been associated in genome-wide association studies with asthma risk. Ma...

Immunology

  • 2020 - 2022
    • •
  • 8 842 tis. Kč
    • •
  • 8 647 tis. Kč
    • •
  • GA ČR
Project

Immune recognition and cell signaling in cancer modulation by bylcoconjugates (IAA500200509)

receptors belonging to immunoglobulins (Ig- FcgammaR) and lectins (NKR-P1, Ly49, CD69), and involment of the other molecules as adaptors and co-receptors (NKG2D) in presence of GD for the lectin-like lymphocyte recepto...

EC - Imunologie

  • 2005 - 2009
    • •
  • 4 220 tis. Kč
    • •
  • 4 220 tis. Kč
    • •
  • AV ČR
Project

Functional and structural heterogeneity of membrane microdomains in mast cells activated via dimerized IgE receptor (GA301/03/0596)

Histamine and other mediators of allergic reactions are released from mast cells and basophils after the binding of a multivalent allergen to high-affinity IgE receptor (FceRI)-IgE complexes. The first biochemical event aft...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 1 995 tis. Kč
    • •
  • 1 995 tis. Kč
    • •
  • GA ČR
Project

The role of F-actin in mast cell activation (IAA7052006)

, tyrosine phosphorylation of the high- affinity IgE receptors, and polymerization and caps of aggregated receptors by as yet unknown mechanisms. This proposal originates recruitment into regions of aggregated membrane ...

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 2 716 tis. Kč
    • •
  • 1 611 tis. Kč
    • •
  • AV ČR
Project

VDJ recombination as a research tool in normal and malignant hematopoiesis (GP310/09/P058)

V-D-J recombination generates diversity of immunoglobulin (Ig) and T-cell (TCR) receptor genes using assembly of various gene segments. We want to study two aspects of V-D-J recombination: The first aspect includes clonal Ig

EC - Imunologie

  • 2009 - 2011
    • •
  • 1 607 tis. Kč
    • •
  • 1 607 tis. Kč
    • •
  • GA ČR
Project

Next generation sequencing for analysis of antigen receptor rearrangements and its use for assessment of immune system pathologies (NT14343)

. NGS offers an ideal tool for assessment of immunoglobulin (Ig) and T-cell receptor receptors. In this project we want to validate the method for minimal residual disease. Concurrently with MRD, it will be possible to stud...

EC - Imunologie

  • 2013 - 2015
    • •
  • 5 852 tis. Kč
    • •
  • 5 852 tis. Kč
    • •
  • MZ
Project

Regulatory roles of Lyn kinase in mast cell activation (IAA5052310)

The first step in mast cell activation after aggregation of the high affinity IgE receptor (FceRI) is tyrosine phosphorylation of the receptor subunits. However, the regulation and consequences of Lyn kinase activity in res...

EC - Imunologie

  • 2003 - 2006
    • •
  • 2 778 tis. Kč
    • •
  • 2 167 tis. Kč
    • •
  • AV ČR
Project

The regulatory role of NTAL in receptor-mediated signaling in mast cells (GA301/06/0361)

Aggregation of the high-affinity IgE receptor (FceRI) leads to tyrosine phosphorylation of numerous substrates including the adaptor protein LAT. Recently, we identified in mast cells a new adaptor protein NTAL, which is structurall...

EC - Imunologie

  • 2006 - 2008
    • •
  • 4 831 tis. Kč
    • •
  • 4 831 tis. Kč
    • •
  • GA ČR
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