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71 (0,118s) •

Project

Innovative method of immunoglobulins administration (TJ04000443)

immunoglobulins. We assume w/o/w double emulsion enables the protection of immunogobulins gastrointestinal tract simulation. Furthermore, the release of immunoglobulins from the w/o/w immunoglobulins are required. Immu...

Chemical process engineering

  • 2020 - 2022
    • •
  • 3 799 tis. Kč
    • •
  • 3 209 tis. Kč
    • •
  • TA ČR
Project

Investigation of regulatory components of the immunoglobulin translation machinery in multiple myeloma as novel therapeutic targets (GA22-26981S)

Malignant transformation of plasma cells leads to the development of multiple myeloma. The tremendous production of immunoglobulin is a typical myeloma hallmark of the ubiquitin system, particularly deubiquitinase OTUD1, in the immunoglo...

Cell biology

  • 2022 - 2024
    • •
  • 9 065 tis. Kč
    • •
  • 9 065 tis. Kč
    • •
  • GA ČR
Project

Identification of immunoglobulin and T-cell receptor genes rearrangements for detection of clonality and residual disease in lymphoid malignancies. (IZ3425)

The analysis of clonospecific rearrangements of T-cell receptor and immunoglobulin genes will improve the diagnosis of non Hodkin s lymphomas and monitoring of minimal residual disease in acute lymphoblastic leukemias in children.......

FG - Pediatrie

  • 1996 - 1999
    • •
  • 3 745 tis. Kč
    • •
  • 3 745 tis. Kč
    • •
  • MZ
Project

Cytokines in relationship to immunoglobulin production in multiple sclerosis. (IZ2777)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1995 - 1997
    • •
  • 1 155 tis. Kč
    • •
  • 1 155 tis. Kč
    • •
  • MZ
Project

Preparation of immunoglobulins with defined specificities from milk, colostrum or eggs of immunized donors (EP0960006625)

on the development and testing of methods of careful separation of immunoglobulins from small. Instructions for use of the immunoglobulins in the preapration of diagnostic reagents......

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 1996 - 2000
    • •
  • 5 546 tis. Kč
    • •
  • 4 946 tis. Kč
    • •
  • MZe
Project

Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis (GP309/02/D066)

The goals of the project Free light chains of immunoglobulins in cerebrospinal fluid, serum and urine in multiple sclerosis are as follows: 1) to confirm the significance of the determination of free light chains of immunoglobulins ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2005
    • •
  • 72 tis. Kč
    • •
  • 47 tis. Kč
    • •
  • GA ČR
Project

The significance of the analysis of the pairs of immunoglobulin heavy/light chains by Hevylite TM in monoclonal gammopathy of undetermined significance and multiple myeloma (NT12451)

Assessment of the significance of serum levels of the pairs of heavy/light immunoglobulin chains including the HLC kappa/lambda index using the Hevylite TM method in MGUS and multiple myeloma. Comparison of the HLC method with gel and immuno...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 6 254 tis. Kč
    • •
  • 6 254 tis. Kč
    • •
  • MZ
Project

Clonal analysis of antigen specific B lymphocytes from patients with rheumatoid arthritis using single-cell RT-PCR (NK7273)

Analysis of immunoglobulin genes on the mRNA level in individual citrulline specific B lymphocytes. Investigation of clonality of B cells and possible restricted usage and pairing of expressed VH and VL Ig genes. Conlusions deduced from the ...

FP - Ostatní lékařské obory

  • 2002 - 2004
    • •
  • 6 205 tis. Kč
    • •
  • 5 828 tis. Kč
    • •
  • MZ
Project

Targets and consequences of activation-induced cytidine deaminase-mediated mutagenesis in tumours (GN24-11338I)

Activation-induced cytidine deaminase (AID) causes mutations in immunoglobulin genes of activated B cells and is required for the production of high-affinity antibodies. However, AID also causes mutations in non-immunoglobulin genes...

Cell biology

  • 2024 - 2027
    • •
  • 6 323 tis. Kč
    • •
  • 6 323 tis. Kč
    • •
  • GA ČR
Project

Ontogenetic development of immune systém cdells and their surface structures (GA304/01/0850)

Ontogenetic model - early postnatal and fetal piglets without mother -fetus immunoglobulin transfer, will be used in studies of spontaneous development of immune defense mechanisms with possibility of their influencing. Attention will be dev...

EA - Morfologické obory a cytologie

  • 2001 - 2003
    • •
  • 1 783 tis. Kč
    • •
  • 1 748 tis. Kč
    • •
  • GA ČR
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