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Projects

280 projects (0,222s)

Project

Insulin mimetics (GA14-17305S)

Insulin is a protein hormone, which controls a wide range of cellular processes as e.g. regulation of blood glucose uptake. Insulin is a molecule of major therapeutic importance for the treatment of millions of diabetic patients.

FR - Farmakologie a lékárnická chemie

  • 2014 - 2016
  • 7 721 tis. Kč
  • 7 721 tis. Kč
  • GA ČR
Project

Molecular mechanisms of the etiology of non-insulin dependent diabetes mellitus (NIDDM) (OC B5.10)

The action deals with cellular mechanisms underlying insulin resistance phenomena and with their clinical consequences that manifest themselves, in their most developed forms, as the type II or the non-insulin-dependent diabetes mel...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1994 - 1999
  • 1 440 tis. Kč
  • 1 245 tis. Kč
  • MŠMT
Project

Regulation of the insulin secretion in polycystic ovary syndrome (NR8759)

Polycystic ovary syndrome (PCOS) is connected with insulin resistance and with disturbed insulin secretion , but the literary data are discrepant. Complex evaluation syndrome will be evaluated with eugylcaemic hyperinsulinaemic clam...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
  • 4 918 tis. Kč
  • 4 565 tis. Kč
  • MZ
Project

Uterine fibroids and insulin resistance (NR8057)

This project is based on assessment of insulin resistance using insulin test and lipidogram and assessment of hormonal changes in women with fibroids and healthy controls. Our goal is to find out eventual relation between two entiti...

FK - Gynekologie a porodnictví

  • 2004 - 2005
  • 799 tis. Kč
  • 655 tis. Kč
  • MZ
Project

The role of T- and R-conformations of insulin in binding to the insulin receptor (GPP207/11/P430)

Insulin is a protein hormone that plays a key role in regulation of blood. Insulin is known to act through binding to the insulin receptor (IR); however of insulin represent only inactive storage forms. It is widel...

CE - Biochemie

  • 2011 - 2013
  • 2 554 tis. Kč
  • 2 554 tis. Kč
  • GA ČR
Project

Human insulin and its analogues Semisynthetic approache. (PZ-Z2/32)

Biological and physiochemical evaluation of human insulin intermediates. Design and preparation of selected human insulin analogue isolation and physiochemical and biological evaluatio.......

FR - Farmakologie a lékárnická chemie

  • 1997 - 2000
  • 11 044 tis. Kč
  • 4 991 tis. Kč
  • MH
Project

Insulin resistance, obesity and diabetes mellitus in the elderly (OC B17.10)

Insulin resistance, obesity and diabetes mellitus in the elderly...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2005
  • 7 061 tis. Kč
  • 2 804 tis. Kč
  • MŠMT
Project

The role of adipocytokines and fatty acids in the disorders of insulin sensitivity and insulin secretion in metabolic syndrome (NR9387)

This project is designed to assess the role of secretion products of adipose tissue, nonesterified fatty acids and adipocytokines, in the development of peripheral tissue insulin resistance and insulin secretion and to establish new...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
  • 5 133 tis. Kč
  • 5 119 tis. Kč
  • MZ
Project

The role of PPAR-alfa in the regulation of insulin sensitivity. (NB7429)

of glucose metabolism and insulin sensitivity. Euglycemic-hyperinsulinemic clamp will be used to measure the changes of insulin sensitivity in patients with insulin will be used to measure the changes of insulin s...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
  • 3 134 tis. Kč
  • 3 035 tis. Kč
  • MZ
Project

The role of CNS in the pathophysiology of insulin resistance (NR8991)

, insulin-resistant and healthy subjects. The aim of the study is to evaluate the effect and adipokine metabolism in diabetic, insulin-resistant and healthy subjects. The aim of thebrain tissue, neurosteriod and adipokine metabolism...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
  • 9 941 tis. Kč
  • 9 003 tis. Kč
  • MZ
  • 1 - 10 out of 280