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381 (0,128s) •

Project

The composition of the oral and intestinal microbiome as a predictor for response to therapy in patients with head and neck carcinoma (NU23-03-00274)

effects. It was established that oral and intestinal bacteria can contribute to therapeutic response in cancer as microbiome-produced factors may affect the treatment sensitivity. Furthermore, RT/CRT distorts the intestinal

Otorhinolaryngology

  • 2023 - 2026
    • •
  • 12 359 tis. Kč
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  • 12 359 tis. Kč
    • •
  • MZ
Project

Study on association between intestinal microbiome and increased risk of chronic inflammatory diseases of locomotor system, osteoporosis and rheumatoid arthritis. (NV18-05-00394)

that estrogen deficiency after menopause affects the gut microbiome, and that deterioration in postmenopausal women may adjust the intestinal barrier and thus affect the speed and degree of the intestinal barrier disorders...

General and internal medicine

  • 2018 - 2022
    • •
  • 13 802 tis. Kč
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  • 13 776 tis. Kč
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  • MZ
Project

Mapping interactions between essential metabolic pathways and intestinal microbiota (GJ17-24592Y)

at the level of key intermediates with respect to reduced or altered intestinal microbiome and microbiome produced) will be profiled and quantitatively determined using mass spectrometry and microbiome diversity w...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2017 - 2021
    • •
  • 4 514 tis. Kč
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  • 4 514 tis. Kč
    • •
  • GA ČR
Project

Changes in the microbiome composition as a risk factor in the development of psoriasis (NV15-30782A)

triggers. We hypothesize that skin microbiome composition is the crucial aspect out the alterations in microbiome in skin affected by psoriasis and in unaffected intestinal barrier disruption as possible cause of systemic ...

FO - Dermatovenerologie

  • 2015 - 2018
    • •
  • 6 426 tis. Kč
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  • 6 426 tis. Kč
    • •
  • MZ
Project

Functional interaction between host gene regulation and the microbiome in the primate gut (LH15175)

The gut microbiome plays a vital role in the host physiological landscape (e.g. diet) are important drivers of gut microbiome composition in humans functional interactions between host gene regulation and the microbiome in ...

EE - Mikrobiologie, virologie

  • 2015 - 2017
    • •
  • 1 997 tis. Kč
    • •
  • 1 997 tis. Kč
    • •
  • MŠMT
Project

The role of intestinal microbiome indole metabolites in the control of gastro-hepatic regulation of lipid and xenobiotic metabolism (GA19-00236S)

data are available for the effects of indole-based products of gut microbiome on regulation of intestinal/liver cell functions, mediated via the xenobiotic sensors AhR impact of indoles on intestinal/liver cells. This proj...

Cell biology

  • 2019 - 2021
    • •
  • 9 271 tis. Kč
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  • 9 194 tis. Kč
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  • GA ČR
Project

Microbial catabolites of tryptophan as modulators of intestinal health via aryl hydrocarbon receptor (GA20-00449S)

hydrocarbon receptor (AhR), having significant roles in intestinal physiology approach to general intestinal health. That is, how do the combinatorial events of each metabolite that are present together influence AhR mediated trans...

Pharmacology and pharmacy

  • 2020 - 2022
    • •
  • 7 968 tis. Kč
    • •
  • 7 968 tis. Kč
    • •
  • GA ČR
Project

Pharmacological mimicry of microbial metabolites in the modulation of intestinal health (GA22-00355S)

Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are frequent and life-threatening intestinal illnesses with devastating socio-economic impact for the intestinal health, whereas insufficient or over-activation of the PXR...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 11 892 tis. Kč
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  • 11 892 tis. Kč
    • •
  • GA ČR
Project

Gut microbiota and host intestinal inflammation. Mechanism of bacterial and butyrate action in alleviating the consequences of dysbiosis (GA19-08294S)

Short-chain fatty acids (SCFA-butyrate, propionate, acetate) are the intestinal demonstrated their anti-inflammatory properties, positive effects on intestinal epithelium), intestinal hormones, transporters and metabolite-s...

Physiology (including cytology)

  • 2019 - 2023
    • •
  • 14 462 tis. Kč
    • •
  • 14 426 tis. Kč
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  • GA ČR
Project

The role of microbiome in pathogenesis of intraocular, systemic and central nervous system lymphoma (NU20-03-00253)

and the intestinal microbiota, it is not surprising that some lymphomas such as mucosa-associated knowledge of the composition, influence and differences in microbiome in patients, intraocular fluids, CSF, serum and microbiome<...

General and internal medicine

  • 2020 - 2023
    • •
  • 17 369 tis. Kč
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  • 17 369 tis. Kč
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  • MZ
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