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465 (0,218s) •

Project

The role of ATF2 transcription factor in development and homeostasis of colon and its involvement in progression of colorectal carcinoma (LTAB19002)

1) Characterisation of lethal phenotype in ATF2 KO mouse model 2) Mapping of ATF2 expression during development and in adult tissues 3) Distinguishing tissue specific roles (Inducible Knock out startegy) 4) Molecular context of ATF2 in intesti...

Genetics and heredity (medical genetics to be 3)

  • 2019 - 2021
    • •
  • 1 200 tis. Kč
    • •
  • 1 200 tis. Kč
    • •
  • MŠMT
Project

The role of extracellular matrix-mediated cell adhesion in maintenance of colonic tissue homeostasis and in colon carcinogenesis (GA305/09/1526)

Right physiological functioning of the intestinal tissue is important) interaction loss. The main aim of the project is to demonstrate the role of intestinal epithelial cell anchorage mediated by ECM in maintenance of colonic tissue...

ED - Fyziologie

  • 2009 - 2011
    • •
  • 2 718 tis. Kč
    • •
  • 2 718 tis. Kč
    • •
  • GA ČR
Project

Characterization of early stages of intestinal tumorigenesis induced by non-physiological activation of Wnt signaling (GA20-31322S)

dedicated to elucidation of early steps of intestinal tumorigenesis caused by the loss lesions formed in the small intestinal villi after Wnt pathway hyperactivation 2, the role of transcription factor Onecut2 during intestinal...

Cell biology

  • 2020 - 2022
    • •
  • 8 985 tis. Kč
    • •
  • 8 985 tis. Kč
    • •
  • GA ČR
Project

Microbial catabolites of tryptophan as modulators of intestinal health via aryl hydrocarbon receptor (GA20-00449S)

hydrocarbon receptor (AhR), having significant roles in intestinal physiology approach to general intestinal health. That is, how do the combinatorial events of each metabolite that are present together influence AhR mediated trans...

Pharmacology and pharmacy

  • 2020 - 2022
    • •
  • 7 968 tis. Kč
    • •
  • 7 968 tis. Kč
    • •
  • GA ČR
Project

Wnt signaling in self-renewal and tumorigenesis of the intestinal epithelia (GAP305/11/1780)

The role of the Wnt signaling pathway in development and proper homeostasis of intestinal cancer. The first part of the project is focused on the Wnt signaling target in intestinal neoplasia. We will elucidate, using mouse ...

EB - Genetika a molekulární biologie

  • 2011 - 2014
    • •
  • 8 400 tis. Kč
    • •
  • 8 400 tis. Kč
    • •
  • GA ČR
Project

Wnt ligands and Wnt-secreting cells for intestinal homeostasis, regeneration and colon cancer a complex world beyond the cancer-activating mutation (GA18-21466S)

of most abundant, but also most enigmatic ligand Wnt5a for intestinal renewal...

Developmental biology

  • 2018 - 2022
    • •
  • 8 406 tis. Kč
    • •
  • 7 632 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms underlying cell-fate decisions in the intestine (GA14-33952S)

Gastrointestinal epithelia represent the most rapidly self-renewing tissue in the adult mammalian body. The homeostasis of the single-layer epithelium depends development of CBC stem cells in the small intestine. The principal objec...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 7 470 tis. Kč
    • •
  • 7 470 tis. Kč
    • •
  • GA ČR
Project

The mechanisms of enteric defensin-dependent intestine autoimmunity (GA17-25365S)

Enteric α-defensins belong to a superfamily of antimicrobial peptides secreted by intestinal Paneth cells and are essential for the gut homeostasis. We have recently described a novel mechanism in patients with Autoimmune PolyEndocr...

EC - Imunologie

  • 2017 - 2021
    • •
  • 7 247 tis. Kč
    • •
  • 6 734 tis. Kč
    • •
  • GA ČR
Project

The role of intestinal microbiome indole metabolites in the control of gastro-hepatic regulation of lipid and xenobiotic metabolism (GA19-00236S)

on regulation of intestinal/liver cell functions, mediated via the xenobiotic sensors AhR of metabolism of xenobiotics and lipid homeostasis within the gut-liver axis. Using impact of indoles on intestinal/liver cells. Thi...

Cell biology

  • 2019 - 2021
    • •
  • 9 271 tis. Kč
    • •
  • 9 194 tis. Kč
    • •
  • GA ČR
Project

Mapping interactions between essential metabolic pathways and intestinal microbiota (GJ17-24592Y)

at the level of key intermediates with respect to reduced or altered intestinal microbiome...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2017 - 2021
    • •
  • 4 514 tis. Kč
    • •
  • 4 514 tis. Kč
    • •
  • GA ČR
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