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4 045 (0,187s) •

Project

Reliable calculations and predictions of NMR chemical shifts for the structural characterization of phosphorylated intrinsically disordered proteins (GJ19-14886Y)

magnetic resonance (NMR) chemical shifts (CSs) in phosphorylated intrinsically disordered proteins (IDPs). The proteins are e.g. involved in the molecular mechanisms of the proteins become a major hurdle ...

Physical chemistry

  • 2019 - 2022
    • •
  • 5 250 tis. Kč
    • •
  • 5 250 tis. Kč
    • •
  • GA ČR
Project

Characterization of intrinsically disordered proteins (GF20-05789L)

Intrinsically disordered proteins (IDPs) are biopolymers interesting both from biophysical and physiological point of view, but difficult to study by the currently available methods. IDPs cannot be described by a single rep...

Biophysics

  • 2020 - 2022
    • •
  • 8 686 tis. Kč
    • •
  • 8 686 tis. Kč
    • •
  • GA ČR
Project

Structural protein disorder brings order into bacterial transcription (GA22-12023S)

Our knowledge of intrinsically disordered proteins (IDPs) is still in its infancy. The delta subunit of bacterial RNA polymerase (RNAP), containing an intrinsically disordered C-terminal domain (CTD), is a...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 12 266 tis. Kč
    • •
  • 12 266 tis. Kč
    • •
  • GA ČR
Project

Disentangling transient interactions in transcription elongation (GX25-15442X)

Intrinsically disordered regions are particularly enriched in the nuclear proteome and their numerous roles include linking specific effector domains into large multi-subunit complexes or mediating abundant transient interactions wi...

Biochemistry and molecular biology

  • 2025 - 2029
    • •
  • 43 344 tis. Kč
    • •
  • 43 344 tis. Kč
    • •
  • GA ČR
Project

Protein liquid-liquid phase separation and intrinsic disorder in bacterial transcription (GA25-16037S)

Liquid-liquid phase separation (LLPS) of proteins results in condensates that play key roles in the cell. LLPS often depends on intrinsically disordered proteins of a partially disordered mycobacterial sig...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 17 467 tis. Kč
    • •
  • 17 467 tis. Kč
    • •
  • GA ČR
Project

Efficient free energy and enhanced sampling calculations of protein-­‐protein interactions (GF15-34684L)

tools to compute the binding free energy for complex protein systems. As a model system, the 14-­‐3-­‐3 family of proteins and their interaction with phosphorylated proteins/peptides is selected. In the unbound state, the...

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2017
    • •
  • 6 221 tis. Kč
    • •
  • 6 221 tis. Kč
    • •
  • GA ČR
Project

Development of high-resolution methodology for NMR studies of disordered proteins with highly degenerated resonance frequencies (GAP206/11/0758)

Description of physical and chemical behavior of unstructured proteins is important for understanding of the process of protein folding in a living cell. Moreover, many proteins are intrinsically disordered

CB - Analytická chemie, separace

  • 2011 - 2013
    • •
  • 3 588 tis. Kč
    • •
  • 3 588 tis. Kč
    • •
  • GA ČR
Project

The interplay between the LEDGF chromatin reader and protein interaction modules (GA22-03028S)

, where the N-terminal chromatin reader domain is connected to the C-terminal protein interaction domain via a long intrinsically disordered region. Although it is predicted chromatin recognition and protein intera...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 022 tis. Kč
    • •
  • 7 842 tis. Kč
    • •
  • GA ČR
Project

Atomic-resolution characterization of microtubule associated protein 2c (MAP2c) and of modifications regulating its function (GA15-14974S)

Intrinsically disordered proteins (IDPs) are macromolecules interesting both form biophysical and physiological point of view, but difficult to study associated protein 2c (MAP2c), a 49 kDa IDP involved in an early...

BO - Biofyzika

  • 2015 - 2018
    • •
  • 6 460 tis. Kč
    • •
  • 6 460 tis. Kč
    • •
  • GA ČR
Project

Translating microtubule envelope sectioning into cytoskeletal structure and function (GA20-04068S)

that the intrinsically-disordered protein (IDP) tau, in a phase separation-like process, reversiblyModulating the accessibility of microtubules for associated proteins or recruit specific proteins. As IDP...

Biophysics

  • 2020 - 2022
    • •
  • 7 804 tis. Kč
    • •
  • 7 804 tis. Kč
    • •
  • GA ČR
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