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26 (0,169s) •

Project

The role of the JAK/STAT signalling pathway in cellular senescence (GA204/08/1418)

Cellular senescence is proposed to be a tumorigenesis barrier to slow or inhibit the progression of proneoplastic lesions to neoplasia. In our recent work we found persistent activation of JAK/STAT signaling pathway during drug-induced senes...

CE - Biochemie

  • 2008 - 2012
    • •
  • 6 643 tis. Kč
    • •
  • 6 643 tis. Kč
    • •
  • GA ČR
Project

Analysis of expression of STAT, JAK and SOCS in glial tumors of brain and in carcinomas of breast and prostate gland. Correlation with grading, expression of steroid receptors and expression (1A8244)

Disruption of signaling of JAK/STAT/SOCS may be the cause of failure of immune surveillance and may participate in development and invasion of various tumors, including carcinomas of prostate gland, breast and glial tumors of brain. The aim ...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 1 665 tis. Kč
    • •
  • 1 419 tis. Kč
    • •
  • MZ
Project

Genetic predispositions to myeloproliferative neoplasms in JAK/STAT pathway (LTAUSA17142)

The aims of this project is the identification of the new genetic predisposition to myeloproliferative neoplasms (MPN) and their in vitro/vivo characterization, especially congenital weakly activating mutations in the JAK/STAT pathway. We pr...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 3 996 tis. Kč
    • •
  • 3 996 tis. Kč
    • •
  • MŠMT
Project

Inhibition of JAK/STAT3 signalling pathway in cancer therapy (GA18-14259S)

JAK/STAT3 signaling pathway plays a crucial role in oncogenesis and development of cellular senescence, thus its inhibition is a promising way to control cancer progression and to suppress adverse effects of senescent cells on tissue microen...

Medicinal chemistry

  • 2018 - 2022
    • •
  • 11 770 tis. Kč
    • •
  • 11 355 tis. Kč
    • •
  • GA ČR
Project

DNA demethylation in the IFNγ signalling pathway modulates tumour progression and tumour-cell interactions with the immune system. (GA15-24769S)

IFNγ is a cytokine capable to induce/modulate tumour cells interaction with immune cells, cell proliferation, and senescence induction through the JAK/STAT signalling pathway. We have hypothesized that changes in DNA methylation of selected ...

EB - Genetika a molekulární biologie

  • 2015 - 2019
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

Development of an intra-operative monitoring and guiding system for dental implantation surgery (LJ11006)

vrtání a jak hluboko. Zabrání se tomu, aby byl například navrtán nervový kanál neukládají implantáty tak hluboko jak by to bylo možné a implantáty hůře drží. Nejširší......

FS - Lékařská zařízení, přístroje a vybavení

  • 2011 - 2012
    • •
  • 10 059 tis. Kč
    • •
  • 2 514 tis. Kč
    • •
  • MŠMT
Project

Analysis of patterns of abnormal leukocyte signaling in childhood diseases using mass cytometry and machine learning. (NU23-07-00170)

The project aims to detect abnormalities in intracellular signaling in patients with inborn errors of hematopoiesis, which manifest as a wide range of symptoms in childhood. We propose to study leukocyte responses to a battery of stimuli via measurem...

Paediatrics

  • 2023 - 2026
    • •
  • 15 611 tis. Kč
    • •
  • 15 611 tis. Kč
    • •
  • MZ
Project

Activites in Computer Graphics International and Eurographics Activities (LA 111)

Účast na konferencích CGI a EG, případně jako chairman sekcí ? Účast na zasedáních edičních rad časopisů Computer Graphics Forum, Computer & Graphics a podpora presentace výsledků vědecké činnosti odborníků z České Republiky ? Přenos poznatků získaný...

JC - Počítačový hardware a software

  • 2000 - 2002
    • •
  • 455 tis. Kč
    • •
  • 308 tis. Kč
    • •
  • MŠMT
Project

Internet4Kids – Learning about the internet a conceptual change perspective (GA22-20771S)

Děti jsou častými uživateli internetu. Málo se však ví, jak si utváření své porozumění internetu a jeho fungování. V projektu zjistíme, jaké prekoncepce mají děti v různém věku o struktuře internetu a jeho fungování, co se o tomto tématu zvl...

Cognitive sciences

  • 2022 - 2024
    • •
  • 5 144 tis. Kč
    • •
  • 5 144 tis. Kč
    • •
  • GA ČR
Project

Molecular and functional cancer-associated perturbances in JAK/STAT/SOCS proteins and in their target genes expression (NR8341)

The study intends to analyze molecular and functional cancer-specific abnormalities in STAT/SOCS signaling proteins and in the expression of their target genes which might represent new tumor markers and be of help in immunotherapeutic strategies. Th...

EC - Imunologie

  • 2005 - 2008
    • •
  • 12 627 tis. Kč
    • •
  • 12 366 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 26