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15 (0,153s) •

Project

Mechanisms of emergence and spread of glycopeptide resistance in Staphylococcus haemolyticus (NV15-28807A)

Staphylococcus haemolyticus is one of the most multidrug-resistant species associated with nosocomial infections. Glycopeptides (GP) are among few antibiotic classes which retain relatively acceptable activity against multidrug-resistant S. haemolyt...

EE - Mikrobiologie, virologie

  • 2015 - 2018
    • •
  • 7 182 tis. Kč
    • •
  • 6 746 tis. Kč
    • •
  • MZ
Project

Experimental development of new antibacterial compounds and assessment of their potential towards combination therapy (NU21-05-00482)

Bacterial infections are a problem that threatens the health of both individuals and whole society, even in economically developed countries. Many staphylococci (methicillin-resistant S. aureus, or coagulase-negative staphylococci resistant to glycop...

Medicinal chemistry

  • 2021 - 2024
    • •
  • 8 073 tis. Kč
    • •
  • 8 073 tis. Kč
    • •
  • MZ
Project

Whole-genome sequencing-based epidemiology and analysis of genetic and physiological features that are associated with the spread of methicillin-resistant and susceptible strains of Staphylococcus aureus and coagulase-negative staphylococci. (NU23-09-00080)

Staphylococci are important pathogenic bacteria capable of causing a wide range of infections. According to the WHO, S. aureus, represented by methicillin-resistant strains (MRSA), is a major threat to global health. In contrast to the clear clinical...

Microbiology

  • 2023 - 2026
    • •
  • 5 158 tis. Kč
    • •
  • 5 158 tis. Kč
    • •
  • MZ
Project

Study of properties of coagulase-negative staphylococci isolated from clinical material. (IZ2677)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1995 - 1997
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • MZ
Project

Detection of microbial contaminants and residues of inhibitory substances in animal products (RE0930950041)

GM - Potravinářství

  • 1993 - 1995
    • •
  • 980 tis. Kč
    • •
  • 1 960 tis. Kč
    • •
  • MZe
Project

The social-pathological dilemma of drug-addiction and the possibilities of preventing it (RS96162)

AM - Pedagogika a školství

  • 1996 - 1996
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MŠMT
Project

Diagnosis, prognosis and resocializing posibilities of the groups endangered by the sociopathological development paying special attention to the youth. (RN19951997008)

AO - Sociologie, demografie

  • 1995 - 1997
    • •
  • 1 083 tis. Kč
    • •
  • 1 083 tis. Kč
    • •
  • MV
Project

Dominant negative mutants of nuclear hormone receptors (NC5261)

A study of the function of dominant negative nuclear hormone receptors that can be involved in pathogenesis of tumors and endocrine disorders using a molecualar biology system of Caenorhabditis elegans.......

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 3 011 tis. Kč
    • •
  • 3 011 tis. Kč
    • •
  • MZ
Project

Epidemiological and genetic analysis of methicillin-resistant Staphylococcus aureus strains according to the WHO "One Health" concept (NU23-09-00488)

Methicillin-resistant Staphylococcus aureus (MRSA) is a major medical problem, but in the last decade it has been encountered not only in hospitalized patients and in the community, but also in some food animals (especially pigs and cattle). Accordin...

Epidemiology

  • 2023 - 2026
    • •
  • 10 403 tis. Kč
    • •
  • 10 403 tis. Kč
    • •
  • MZ
Project

Molecular characterization of adaptive antibiotic resistance and tolerance mechanisms of Staphylococcus aureus strains causing chronic infections (NV17-30460A)

Complex structural changes in the affected tissues develop during the course of chronic bacterial infection and along with antibiotic therapy act as strong stressors exerting a severe selective pressure and resulting in adapted bacterial population t...

EE - Mikrobiologie, virologie

  • 2017 - 2020
    • •
  • 8 659 tis. Kč
    • •
  • 8 659 tis. Kč
    • •
  • MZ
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