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1 428 (0,107s) •

Project

The role of mitochondrial IDH2 in bioenergetics, redox regulations, and cancer (GPP301/12/P381)

of the reversed Krebs cycle, which depends on presence of IDH2 in mitochondria. We intend towards reductive and oxidative pathways in Krebs cycle at limiting oxygen and glucose......

FD - Onkologie a hematologie

  • 2012 - 2014
    • •
  • 2 430 tis. Kč
    • •
  • 2 430 tis. Kč
    • •
  • GA ČR
Project

Induction of apoptosis in cancer cells by mitochondria-specific compounds; the role of respiratory complex II (GAP301/12/1851)

Redox-silent vitamin E (VE) analogues, such as alpha-tocopheryl succinate (aTOS), eliminate cancer cells by mitochondrially-mediated apoptosis. Respiratory complex II (CII), which converts succinate to fumarate in the Krebs cycle an...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 5 217 tis. Kč
    • •
  • 5 217 tis. Kč
    • •
  • GA ČR
Project

SUCLG2 as a new tumour suppressor affecting mitochondrial metabolism Molecular mechanism and clinical relevance (GA22-07091S)

Succinyl-CoA ligase (SUCL) is a tricarboxylic acid (TCA) cycle enzyme), a regulatory complex at the crossroads of the TCA cycle and oxidative phosphorylation function, including the TCA cycle and OXPHOS. We will study the i...

Oncology

  • 2022 - 2024
    • •
  • 11 148 tis. Kč
    • •
  • 11 136 tis. Kč
    • •
  • GA ČR
Project

Hypoxia-induced Mitochondrial Adaptations as the Unifying Factor of Type 2 Diabetes Development in Sleep Apnea Syndrome (GA18-10144S)

Obstructive sleep apnea syndrome (and other human diseases) is characterized by repetitive or sustained tissue hypoxia during sleep. Mitochondria adapt to hypoxia by employing an evolutionary conserved, predetermined responses based on the reductive ...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2022
    • •
  • 10 671 tis. Kč
    • •
  • 10 671 tis. Kč
    • •
  • GA ČR
Project

The importance of being mitofit targeting mitochondrial metabolism in glioblastoma (GF24-10406K)

Cancer cell proliferation and tumour formation need robust cellular metabolism and energy production to support the anabolic demands for generation of new progeny. Cells with damaged, dysfunctional mitochondria and/or mtDNA are not able to meet thi...

Cell biology

  • 2024 - 2026
    • •
  • 7 312 tis. Kč
    • •
  • 7 312 tis. Kč
    • •
  • GA ČR
Project

Alternative splicing of SUCLG2 and mitochondrial complex II regulation in endocrine cancer (NW25-03-00282)

We have recently described mutations in SUCLG2, a subunit of SUCL, in endocrine tumours, and found that this affected considerably assembly and function of mitochondrial respiratory complex II (CII). When studying the role of SUCLG2 in regulation of ...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 15 457 tis. Kč
    • •
  • 15 457 tis. Kč
    • •
  • MZ
Project

The role of higher sensitivity of interneurons to metabolic stress in the development of schizophrenia (GA22-15096S)

rate, the function of the Krebs cycle and glycolysis enzymes, oxidative stress...

Neurosciences (including psychophysiology)

  • 2022 - 2024
    • •
  • 10 004 tis. Kč
    • •
  • 10 004 tis. Kč
    • •
  • GA ČR
Project

Trypanosomatid biochemistry an insight from the neglected groups (LUASK22033)

Family Trypanosomatidae is a species-rich group of protists parasitizing a wide range of hosts. Several genera are pathogenic to vertebrates, animals, and plants and, thus, they are attractive for research and we have acquired a substantial amount of...

Biochemistry and molecular biology

  • 2022 - 2025
    • •
  • 3 101 tis. Kč
    • •
  • 3 101 tis. Kč
    • •
  • MŠMT
Project

Research of conditions for exercise of cycling transport as an integral and equivalent part of the traffic system (GA103/00/1530)

The 80th have brought a new boost of cycling transport almost in all 90th. In detailed analyse is necessary to submit, that the support of cycling to look for the new directions, that can help to expansion of the cycling tr...

JO - Pozemní dopravní systémy a zařízení

  • 2000 - 2001
    • •
  • 822 tis. Kč
    • •
  • 822 tis. Kč
    • •
  • GA ČR
Project

Development of indoor software for cycling - Rouvy AR (EG17_107/0012061)

Development of indoor software for cycling - Rouvy AR...

JC - Počítačový hardware a software

  • 2017 - 2021
    • •
  • 25 490 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
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