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4 862 (0,073s) •

Project

The role of genetic factors in susceptibility to alcoholic liver disease (NR8023)

The aim of the proposed study is to find combination(s) of genetic variants in 7 genes responsible for the genetic disposition to the development or serious course of ALD. Twelve polymorphisms in the 7 key genes will be analysed in min. 200 patients ...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 1 647 tis. Kč
    • •
  • 1 557 tis. Kč
    • •
  • MZ
Project

Characterization of mRNA variations for novel mitochondrial uncoupling proteins during stimulations by pyrogenic cytokines, thyroid hormones and lipoid compound (GA301/02/1215)

. Primary cell cultures of rat hepatocytes and Kupffer cells, isolated from stimulated...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 6 150 tis. Kč
    • •
  • 2 613 tis. Kč
    • •
  • GA ČR
Project

Mechanisms and consequences of the accumulation of lipids in liver associated with metabolic syndrome - the possibilities of nutritional and pharmacological intervention (NS9696)

1. The IR associated mechanisms determining the impaired ability of adipose tissue to regulate the release and uptake of FFA with respect to the NAFLD development. 2. The role of intensified intracellular Tg turnover due to stimulated activity of lys...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 8 041 tis. Kč
    • •
  • 8 041 tis. Kč
    • •
  • MZ
Project

Mechanisms of disruption of cell-to-cell communication and regulation of cell proliferation in liver cells (GA524/06/0517)

The project aims to is to contribute to understanding of regulation of cell-to-cell communication and proliferation in liver oval cells that are sensitive both of WB-F344 rat liver epithelial cells will be introduc...

ED - Fyziologie

  • 2006 - 2008
    • •
  • 3 007 tis. Kč
    • •
  • 3 007 tis. Kč
    • •
  • GA ČR
Project

Growth and cell cycle - mechanisms of mutual coordination (GA15-09231S)

The cell cycle progression is intricately intertwined with cell growth. In green algae dividing by multiple fission a critical cell size is a prerequisite regulatory point required for the cell cycle entry. Once CP...

EE - Mikrobiologie, virologie

  • 2015 - 2019
    • •
  • 5 639 tis. Kč
    • •
  • 5 639 tis. Kč
    • •
  • GA ČR
Project

Deciphering pancreas development and function at the single-cell level (GA25-15876S)

Understanding the embryonic development of the pancreas, particularly cell fate decisions, endocrine cell differentiation, and functional maturation of endocrine cells for replacing dysfunctional β cells. Our previ...

Developmental biology

  • 2025 - 2027
    • •
  • 11 748 tis. Kč
    • •
  • 11 748 tis. Kč
    • •
  • GA ČR
Project

The relationship between cell size and the size of cellular organelles during early embryonic development in mammals (GA19-24528S)

Despite current progress in cell biology the mechanism how cells maintain conditions are characterized by changes in cell sizes. A maintenance of cell volume cells are actually measuring their volume. Prel...

Technologies involving the manipulation of cells, tissues, organs or the whole organism (assisted reproduction)

  • 2019 - 2022
    • •
  • 7 954 tis. Kč
    • •
  • 7 588 tis. Kč
    • •
  • GA ČR
Project

Cell cycle regulation in human embryonic stem cells - study toward establishing identifiable characteristics of high quality cells (GA301/05/0463)

Many aspects of the biology of human embryonic stem (hES) cells must be understood before any therapeutical application of this cell type is possible. Compromised ability to withdraw from cell cycle often results in uncontr...

EI - Biotechnologie a bionika

  • 2005 - 2007
    • •
  • 2 918 tis. Kč
    • •
  • 2 918 tis. Kč
    • •
  • GA ČR
Project

Charakterization of autologous T cell clones reactive against metastatic melanoma (GA301/04/1387)

cells that are able to specifically destroy tumor cells from patients with metastatic melanoma. Melanoma cell apoptotic bodies-pulsed dendritic cells will be used to activate autologous T cells. Melanoma-...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 987 tis. Kč
    • •
  • 2 987 tis. Kč
    • •
  • GA ČR
Project

Red blood cells in cyprinid fish (GA16-21024S)

Red blood cells represent one of the most abundant specialized cell types in vertebrate organisms. They develop from progenitor cells that are already committed to the red blood cell lineage, like BFU-E and CFU-E s...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 6 972 tis. Kč
    • •
  • 5 991 tis. Kč
    • •
  • GA ČR
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