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560 (0,146s) •

Project

Role of L-arginine, methylarginines and their metabolism in regulation of endothelial homeostasis (GP13-40882P)

about role of L-arginine and methylarginines in the development of ednothelial dysfunction. Molecular mechanism of L-arginine and methylarginines metabolism will be evalueated on cellular (human endothelial cells....

ED - Fyziologie

  • 2013 - 2014
    • •
  • 1 618 tis. Kč
    • •
  • 1 618 tis. Kč
    • •
  • GA ČR
Project

The influence of L-arginine and its analogues on the generation of reactive oxygen and nitrogen species by professional phagocytes (GA524/08/1753)

The aim of the project is to determine the effects of L-arginine and its analogues on the activity of NADPH oxidase, myeloperoxidase and inducible nitric oxide synthase. The activity of enzymes will be analysed in: i) ?chemical? sys...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2008 - 2012
    • •
  • 4 969 tis. Kč
    • •
  • 4 969 tis. Kč
    • •
  • GA ČR
Project

Metabolic effect of L-arginine supplementation and ACE inhibitors in diabetes and renal insuficience. (IZ4201)

The effect of long-term administration of L-arginine, the substrate for nitric oxide synthesis, and ACE inhibitors on metabolic disorders, the function and anti-oxidative capacity of the heart will be investigated.......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 2 122 tis. Kč
    • •
  • 1 539 tis. Kč
    • •
  • MZ
Project

NO and L-arginine metabolism after cadaver renal graft transplantation (NK4906)

L-arginine in CyA toxicity also in a rat model of the ischemic kidney simulating the state after Tx. And this even if initiating therapy with L-arginine after......

FE - Ostatní obory vnitřního lékařství

  • 1998 - 1999
    • •
  • 677 tis. Kč
    • •
  • 484 tis. Kč
    • •
  • MZ
Project

Evaluation of lateralisation of nitric oxide mediator system in the hippocampus of people with schizophrenia and Alzheimer disease (NF7576)

Expression and activity of nitric oxide synthases and concentrations of L-glutamate, L-arginine, L-citrulline, nitrites/nitrates will be determined in both hippocampi of people with schizophrenia, Alzheimer disease...

ED - Fyziologie

  • 2003 - 2005
    • •
  • 5 364 tis. Kč
    • •
  • 5 257 tis. Kč
    • •
  • MZ
Project

Investigating the Symmetric Allosteric Mechanism of Hexameric Escherichia coli Arginine Repressor using Computational Simulations (GA13-21053S)

. Arginine repressor (ArgR) is the master regulator of the arginine regulon in a wide of L-arg. Asymmetric allosteric activation of ArgR is an apparent paradox in view affinities create two action levels in the protein's re...

CF - Fyzikální chemie a teoretická chemie

  • 2013 - 2018
    • •
  • 3 883 tis. Kč
    • •
  • 3 883 tis. Kč
    • •
  • GA ČR
Project

Improved growth of human skin cells on biomimetic nanofibrous matrices for active wound healing (GA17-02448S)

In this Project, the adhesion, growth and phenotypic maturation of human keratinocytes and dermal fibroblasts will be studied in vitro on novel polymeric nanofibrous membranes releasing bioactive amino acids (L-arginine), peptides, ...

FR - Farmakologie a lékárnická chemie

  • 2017 - 2021
    • •
  • 10 527 tis. Kč
    • •
  • 10 131 tis. Kč
    • •
  • GA ČR
Project

The model of ontogeny of the pain (GA305/96/0557)

and NO substrate L-arginine respectively with elektrophysiological correlates....

ED - Fyziologie

  • 1996 - 1998
    • •
  • 1 216 tis. Kč
    • •
  • 1 216 tis. Kč
    • •
  • GA ČR
Project

Effect of intrathecally administered vasodilators on subarachnoid hemorrhage-induced cerebral vasospasm. Animal model experiment. (NT14426)

Vasospasm induced by nontraumatic subarachnoid bleeding is an important cause of ischaemic neurological damage among patients sustaining aneurysmal subarachnoid haemorrhage. Pathophysiology of this process is not fully understood. Apart from endovasc...

FH - Neurologie, neurochirurgie, neurovědy

  • 2013 - 2015
    • •
  • 4 505 tis. Kč
    • •
  • 4 020 tis. Kč
    • •
  • MZ
Project

Reactive oxygen and nitrogen metabolites generated by neutrophils under physiological and pathological conditions (GA524/00/1223)

the employment of antioxidants, NO donors, L-arginine and its analogues for ROM and RNM...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2000 - 2002
    • •
  • 2 581 tis. Kč
    • •
  • 1 943 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 560