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48 (0,153s) •

Project

Genetic plymorphisms, MicroRNAs and bioindicators of activity interrelations in the diagnostics and therapy of severe familial hypercholesterolemia (NV17-28882A)

Over past decade, the crucial role of microRNAs (small RNA molecules of 20-22 nucleotides) as perspective biomarkers, main players of the cardiovascular disease or both, has become widely recognized. By controlling the post-transcriptional gene expre...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 15 886 tis. Kč
    • •
  • 15 886 tis. Kč
    • •
  • MZ
Project

Prediction of cardiovascular risk and prognosis in patients with hypercholesterolaemia through genomic and metabolomic analysis (NU22-01-00151)

(LDL) cholesterol (LDL-C) concentrations. MicroRNAs (miRNAs) have been suggested as emerging regulators of plasma LDL-C concentrations. Notably, there is evidence showing......

Endocrinology and metabolism (including diabetes, hormones)

  • 2022 - 2025
    • •
  • 12 209 tis. Kč
    • •
  • 12 209 tis. Kč
    • •
  • MZ
Project

Postperfusion syndrom II. (IZ1924)

9F - 9

  • 1994 - 1996
    • •
  • 500 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • MZ
Project

Extracorporeal photochemotherapy in cutaneous T-cell lymphomas. (IZ3566)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 914 tis. Kč
    • •
  • 914 tis. Kč
    • •
  • MZ
Project

Lipoperoxidation, LDL composition and risk of cardiovascular diseases. (IZ3596)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1996 - 1998
    • •
  • 1 001 tis. Kč
    • •
  • 979 tis. Kč
    • •
  • MZ
Project

Small size LDL particles as a new risk of premature atherosclerosis (IZ3075)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1995 - 1997
    • •
  • 575 tis. Kč
    • •
  • 531 tis. Kč
    • •
  • MZ
Project

Influence of oxidative modification of proteins on activation of human blood platelets (NK6841)

The aim of the project is to find if oxidized LDL and/or oxidized fibrinogen generated during activation of platelets will be detected. LDL from normal donors will be estimated by several independent methods. Native LDL and...

FP - Ostatní lékařské obory

  • 2001 - 2003
    • •
  • 2 178 tis. Kč
    • •
  • 2 100 tis. Kč
    • •
  • MZ
Project

HDL and LDL lipoprotein subpopulations and fibrinogen influenced by diet with alcohol (NA6590)

Effect of moderate drinking of Moravian white wine and red wine for 4 weeks on HDL and LDL lipoprotein subpopulations, cholesterol esterification and fibrinogen will be studied in 50 men.......

FQ - Veřejné zdravotnictví, sociální lékařství

  • 2001 - 2003
    • •
  • 1 567 tis. Kč
    • •
  • 1 558 tis. Kč
    • •
  • MZ
Project

LDL gene score in the diagnosis of primary hypercholesterolemias and cardiovascular risk assessment (NV15-28277A)

Familial hypercholesterolemia (FH) is autosomal dominant disorder caused mostly by mutations in the LDL-receptor gene or the the gene encoding for apolipoprotein B levels (LDL polygenic score). The phenotype and the risk of complica...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2018
    • •
  • 9 760 tis. Kč
    • •
  • 9 760 tis. Kč
    • •
  • MZ
Project

Proprotein convertase subtilisin/kexin 9 (PCSK9) in the pathophysiology a treatment of dry age-related macular degeneration (NV17-29241A)

of cell surface low density lipoprotein (LDL) cholesterol receptor levels. Decrease that rheohemapheresis also reduces plasma PCSK9 levels by removing LDL cholesterol. The PCSK9 level of LDL receptor function and LDL

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2020
    • •
  • 9 814 tis. Kč
    • •
  • 9 814 tis. Kč
    • •
  • MZ
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