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47 (0,085s) •

Project

Evaluation of effectiveness of the short-term LDL apheresis treatment in patients with hyperlipoproteinemia and coronary artery disease. (NB6134)

Evaluation of efficacy of short term LDL-apheresis in patients with hyperlipidaemia and ischaemic heart disease with accelerated angina pectoris in pre-treatment period that is not manageable by revascularisation procedures and also...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2000 - 2002
    • •
  • 3 010 tis. Kč
    • •
  • 2 011 tis. Kč
    • •
  • MZ
Project

Comparative study of the efficacy, safety and cost-effectiveness of the LDL-apheresis and rheopheresis in the therapy of severe hyperlipoproteinemia (NR9103)

This research will link up the previous experience with specific immunoadsorption (LDL-apheresis) and rheopheresis (cascade filtration) and compare these two methods (effectivity, safety, economy). The aim of the research is to veri...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2009
    • •
  • 3 236 tis. Kč
    • •
  • 3 234 tis. Kč
    • •
  • MZ
Project

Study of atherogenic mechanisms during treatment with LDL-apheresis the role of fatty acid metabolism, cholesterol synthesis and lipoperoxidation (NB6822)

Prospective clinical study of the mutual interactions and particular role of fundamental lipid related atherogenic mechanisms in patients with familial hypercholesterolemia treated by low density lipoprotein apheresis. Project will investiga...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 1 841 tis. Kč
    • •
  • 1 839 tis. Kč
    • •
  • MZ
Project

The role of metabolic, thrombocytic and endothelial dysfunction in process of atherogenesis (NB6549)

will be the confirmation if and how much the quick and deep drop of cholesterol after LDL-apheresisThe aim of the study is to optimalize the therapeutical procedure in cases of severe familial hyperlipoproteinaimia treated with ext...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 1 459 tis. Kč
    • •
  • 1 459 tis. Kč
    • •
  • MZ
Project

Study of molecular mechanism of atherogenesis in familiar hyperlipidaemia. (NB4548)

Prospective clinical study of the molecular mechanism of atherogenesis during LDL-apheresis: 1. Cell membrane structure, 2. Lipoperoxidation formation, 3. Antioxidant consuption, 4. Platelet function......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 2 388 tis. Kč
    • •
  • 2 124 tis. Kč
    • •
  • MZ
Project

Prediction, optimation and individualization of therapeutic procedure in LDL-apheresis - a multivariate model in a prospective study. (NB7006)

The project objectives are to define the most important factors influencing the speed and economy of LDL-aphereses, therapeutic results (substantial reduction of LDL-cholesterol) under conditions of minimal patient´s discomfort. The...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2002 - 2004
    • •
  • 1 493 tis. Kč
    • •
  • 1 490 tis. Kč
    • •
  • MZ
Project

Genetic plymorphisms, MicroRNAs and bioindicators of activity interrelations in the diagnostics and therapy of severe familial hypercholesterolemia (NV17-28882A)

lipoprotein apheresis treatment. We expect that robust changes of lipid homeostasis, induced by lipoprotein apheresis, might bring further insights into the role......

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 15 886 tis. Kč
    • •
  • 15 886 tis. Kč
    • •
  • MZ
Project

Unstable ateromatous plaque the possibilities to influence the prognosis of clinically important organ atherosclerosis (NR8062)

Prospective clinical study of the mutual interactions and particular role of fundamental lipid related atherogenic mechanisms in patients with severe hypercholesterolemia treated by low density lipoprotein apheresis. Project will investigate...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2004 - 2006
    • •
  • 1 984 tis. Kč
    • •
  • 1 945 tis. Kč
    • •
  • MZ
Project

Prediction of cardiovascular risk and prognosis in patients with hypercholesterolaemia through genomic and metabolomic analysis (NU22-01-00151)

(LDL) cholesterol (LDL-C) concentrations. MicroRNAs (miRNAs) have been suggested as emerging regulators of plasma LDL-C concentrations. Notably, there is evidence showing inhibitors and lipoprotein apheresis and w...

Endocrinology and metabolism (including diabetes, hormones)

  • 2022 - 2025
    • •
  • 12 209 tis. Kč
    • •
  • 12 209 tis. Kč
    • •
  • MZ
Project

Rheologic, functional, and structural aspects of atherogenesis the impact of extracorporeal hemorheotherapy on microcirculation (NR8505)

The research objective is therapeutic affection of rheologic conditions in microcirculation with extracorporeal hemorheotherapy in vascular complications of accelerated atherosclerosis in hyperlipoproteinemias.Cascade filtration was introduced. Metho...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2005 - 2007
    • •
  • 2 131 tis. Kč
    • •
  • 2 117 tis. Kč
    • •
  • MZ
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