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5 305 (0,098s) •

Project

Epilepsy genetics To solve unsolvable cases with combined OMICs tools (NU20-04-00279)

be further testing, namely by whole-exome (WES), whole-genome (WGS) and long read sequencing (LRS). We plan to examine about 200 of already selected patients implemented a massively parallel sequencing (M...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2020 - 2023
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  • 8 984 tis. Kč
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  • 8 984 tis. Kč
    • •
  • MZ
Project

Exploring causes of the neurogenetic disorders with the newest genomic methods (NU22-04-00097)

. Moreover, we will extend our research with a new method, the long-read sequencing (LRS). LRS can detect variants not visible with WES or WGS. Therefore, we will use LRSThe diagnostic yield of ...

Genetics and heredity (medical genetics to be 3)

  • 2022 - 2025
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  • 10 731 tis. Kč
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  • 10 731 tis. Kč
    • •
  • MZ
Project

Characterization of the molecular machinery regulating the recruitment of signaling molecules to lipid rafts (GA310/09/2084)

is thecharacterization of molecular machinery regulating the recruitment of signaling molecules to LR. Objectives are: (i) to identify proteins interacting with LR targeting sequence of Lck. The critical event in this proc...

EC - Imunologie

  • 2009 - 2014
    • •
  • 6 750 tis. Kč
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  • 6 750 tis. Kč
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  • GA ČR
Project

Evolutionary new centromeres in plants (GA23-06840S)

frequency of ENCs in plants. Improvements in long-read sequencing, coupled using long-read sequencing methods complemented by cytogenomic and epigenetic......

Plant sciences, botany

  • 2023 - 2025
    • •
  • 12 446 tis. Kč
    • •
  • 12 446 tis. Kč
    • •
  • GA ČR
Project

Employing ultra-long read sequencing to elucidate origin and evolution of satellite DNA in plant genomes (GA20-24252S)

a cutting edge nanopore sequencing protocols to generate ultra-long sequence reads that will provide insight into long-range organization of satellite repeat arrays. This methodHighly repetitive, tandemly...

Genetics and heredity (medical genetics to be 3)

  • 2020 - 2022
    • •
  • 8 215 tis. Kč
    • •
  • 8 215 tis. Kč
    • •
  • GA ČR
Project

Parsing and Translation (GP201/02/D053)

Canada, we have discovered a new, faster version of sequential generalized LR (GLR reads one symbol on every transition and performs less stack operations. Its first directed by LR parsing for translations generated by eve...

JC - Počítačový hardware a software

  • 2002 - 2005
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  • 653 tis. Kč
    • •
  • 353 tis. Kč
    • •
  • GA ČR
Project

Advanced sequencing methods for deciphering structural variants in cancer genome (NU21-08-00237)

lesions. Long-read sequencing is a technique that can read kilobases long DNA sequences, providing detailed information about primary DNA structure and genomic with DC or cth abnormalities with <...

Human genetics

  • 2021 - 2025
    • •
  • 12 671 tis. Kč
    • •
  • 12 671 tis. Kč
    • •
  • MZ
Project

Even plants can lose their sex drive Exploring the links between hybridization, chromosomal reorganization and evolution of apomixis (GA24-11371S)

with apomixis. Recent sequencing advances enable telomere-to-telomere genome assembly, including centromeres. Our goal is to analyze Boechera genomes using long-read sequencing methods, complemented by cytogenomic...

Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

  • 2024 - 2026
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  • 11 628 tis. Kč
    • •
  • 11 628 tis. Kč
    • •
  • GA ČR
Project

Screening of mutations in the duplicated region of the PKD1 gene from families with autosomal dominant polycystic kidney disease (NR9427)

Analysis of mutations in duplicated region of the PKD1 gene in selected families with ADPKD by LR-PCR , screening methods (SSCP,HA,DGGE) and following sequencing of positive fragments.......

EB - Genetika a molekulární biologie

  • 2007 - 2010
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  • 4 789 tis. Kč
    • •
  • 4 669 tis. Kč
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  • MZ
Project

Diversity of arbuscular mycorrhizal fungal mycelial traits and their relation to ecological niches (LUAUS25238)

of the intraradical mycelium over time in selected AM fungal taxa 4) Sequence a 2.5 kb rDNA fragment of all studied target AM taxa fungi using a high throughput long-read sequencing method 5) Create a database of ...

Ecology

  • 2025 - 2028
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  • 9 035 tis. Kč
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  • 9 035 tis. Kč
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  • MŠMT
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