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4 378 (0,113s) •

Project

Label-free super-resolution microscopy based on single-protein fluctuations to study the assembly of tau protein envelopes (GA23-07703S)

the mechanisms of tau aggregates formation at single-protein details we will introduce a new label-free method based on direct detection of single-protein fluctuation usingIn neuronal cells, tau proteins ...

Cell biology

  • 2023 - 2025
    • •
  • 9 981 tis. Kč
    • •
  • 9 981 tis. Kč
    • •
  • GA ČR
Project

Dynamics and thermodynamics of mouse pheromone-protein complexes (GA203/00/0511)

of pheromone-binding proteins. Mouse MUP-I, previously studied by the joint applicant, was chosen as a protein model. Dynamic parameters describing amide bond motions will be estimated from relaxation data for the free

CF - Fyzikální chemie a teoretická chemie

  • 2000 - 2002
    • •
  • 4 290 tis. Kč
    • •
  • 2 875 tis. Kč
    • •
  • GA ČR
Project

Surpassing the Diffraction Limit in Label-Free Microscopy (LL2409)

In this project, I introduce the next generation of super-resolution microscopy relying on direct and label-free imaging of single-biomolecule fluctuations at high-speed to offer a complementary insight into the complex dynamics of ...

Optics (including laser optics and quantum optics)

  • 2024 - 2026
    • •
  • 24 416 tis. Kč
    • •
  • 24 416 tis. Kč
    • •
  • MŠMT
Project

Optical imaging of single protein dynamics (LL1602)

and tracking the conformational dynamics of proteins at a single-molecular level, at their native time scales, and ultimately without the use of any labels. Understanding the conformations of a protein in its native enviro...

CF - Fyzikální chemie a teoretická chemie

  • 2016 - 2021
    • •
  • 40 738 tis. Kč
    • •
  • 40 738 tis. Kč
    • •
  • MŠMT
Project

Life of a single biomolecule in a motion picture (GA22-18203S)

limitations and to image individual proteins in free motion without any label. Nevertheless, the study of interactions between proteins remains challenging, due single-molecule imaging methods, however, require fl...

Optics (including laser optics and quantum optics)

  • 2022 - 2024
    • •
  • 6 840 tis. Kč
    • •
  • 6 716 tis. Kč
    • •
  • GA ČR
Project

New tools of label-free electrochemical analysis of protein interactions with nucleic acids and proteins (GA18-18154S)

that can contribute by new insights about complex protein systems. We wish to take advantage of electrochemical approaches to design new tools for the analysis of protein in the Applicant laboratory, showing that particularly all <...

Biophysics

  • 2018 - 2021
    • •
  • 3 613 tis. Kč
    • •
  • 3 433 tis. Kč
    • •
  • GA ČR
Project

Platforms for nanopore membrane sensing (GF17-33767L)

to transfer fluorescence recording into label free formats. We will pursue two approaches protein interaction and function. Drug screening has in recent decades suffered both functions manifested by membrane proteins

BM - Fyzika pevných látek a magnetismus

  • 2017 - 2019
    • •
  • 3 123 tis. Kč
    • •
  • 3 102 tis. Kč
    • •
  • GA ČR
Project

Preparation and redioactive labelling of low-molecular weigth proteins and peptides with tissue-specific distribution (NL6071)

Low-molecular weight proteins and poptides produced by degradation of high-molecular weight substances after isolation using chromatographic methods and protein-membrane separation are labelled with the radionuclides 99mTc ...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 1 746 tis. Kč
    • •
  • 1 745 tis. Kč
    • •
  • MZ
Project

Mapping Accessible Surface Area of Soluble and Membrane Proteins by Employing Reactive Probes (GA25-18181S)

, it is worth investigating their potential to label soluble and membrane proteins and thus covalent labeling to chemical cross-linking. In contrast to the HDX, covalent labeling targets amino acid side chains in t...

Analytical chemistry

  • 2025 - 2027
    • •
  • 6 606 tis. Kč
    • •
  • 6 606 tis. Kč
    • •
  • GA ČR
Project

Engineering radionuclide - labeled antibodies (OE 210)

production of prototype radioimunological agent based on protein-engineered antibody with required combination of desirable properties...

EC - Imunologie

  • 2006 - 2009
    • •
  • 18 186 tis. Kč
    • •
  • 9 093 tis. Kč
    • •
  • MŠMT
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