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5 303 (0,145s) •

Project

The establishment of advanced cell therapy for the treatment of limbal stem cell deficiency in the Czech Republic. (TO01000099)

To introduce treatment for a blinding corneal disorder, limbal stem cell deficiency (LSCD), using advanced stem cell-based transplantation therapy into clinical practice. First, a xenogeneic-free ...

Ophthalmology

  • 2021 - 2024
    • •
  • 22 031 tis. Kč
    • •
  • 17 631 tis. Kč
    • •
  • TA ČR
Project

Tissue engineering of genetically competent corneal and conjunctival cells for subsequent grafting in human medicine (7F14156)

of corneal, limbal and conjunctival cells for potential grafting, and will investigate alternative approaches to prolong the "shelf-life" of cells and tissue intended......

FF - ORL, oftalmologie, stomatologie

  • 2014 - 2017
    • •
  • 22 712 tis. Kč
    • •
  • 22 712 tis. Kč
    • •
  • MŠMT
Project

Treatment of severe ocular surface injuries using limbal and mesenchymal stem cells (GA14-12580S)

a limbal region, where limbal stem cells (LSC) responsible for corneal epithelium sources of stem cells, such are mesenchymal stem cells (MSC), and on the use of in vitro expand...

FF - ORL, oftalmologie, stomatologie

  • 2014 - 2016
    • •
  • 5 930 tis. Kč
    • •
  • 5 930 tis. Kč
    • •
  • GA ČR
Project

Targeted differentiation and transdifferentiation of limbal and mesenchymal stem cells and their therapeutic applications in preclinical models (GAP304/11/0653)

Stem cells (SC) share a unique property to differentiate or even transdifferentiate into multiple cell types. This makes them an extremely promising tool is healedby cells that originate from SC located in the limb...

FP - Ostatní lékařské obory

  • 2011 - 2014
    • •
  • 6 904 tis. Kč
    • •
  • 6 904 tis. Kč
    • •
  • GA ČR
Project

Anterior eye segment hypoxia and post-hypoxic injury. The role of oxidative stress. Attempts at the development of effective therapies. (GA304/06/1379)

central, peripheral parts of the cornea and limbal area in relation to limbal stem cells and their role in reparative processes. We suggest that oxidative stress plays......

FF - ORL, oftalmologie, stomatologie

  • 2006 - 2008
    • •
  • 4 991 tis. Kč
    • •
  • 4 991 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms underlying cell-fate decisions in the intestine (GA14-33952S)

on actively cycling crypt base columnar stem cells (CBCs) that reside at the bottom part of microscopic invaginations called crypts. CBCs generate all epithelial cell lineages, including a population of non-dividing reserv...

EB - Genetika a molekulární biologie

  • 2014 - 2018
    • •
  • 7 470 tis. Kč
    • •
  • 7 470 tis. Kč
    • •
  • GA ČR
Project

HMGB proteins involvement in biology of telomeres and human embryonic stem cells (GAP305/12/2475)

or plasmid-directed over-expression) in stably transfected human embryonic stem cells of the key property of stem cells - pluripotency. We also intend to study the involvement instability of the stem ...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 9 740 tis. Kč
    • •
  • 9 740 tis. Kč
    • •
  • GA ČR
Project

Bioartificial cardiovascular patches and vessels from porcine collagen reinforced with nano/microfibers using stem cells and dynamic culture (NV19-02-00068)

with nano/micro fibres, moulded into the required shape along with stem cells are often deficient. Allogeneic or artificial materials are often thrombogenic. The aim amount of subcutaneous fat and blood will be collected f...

Cardiac and Cardiovascular systems

  • 2019 - 2023
    • •
  • 17 153 tis. Kč
    • •
  • 16 889 tis. Kč
    • •
  • MZ
Project

The role of p27 in differentiation of embryoid bodies (KJB5039301)

Any clinical use of pluripotent embryonic stem (ES) cells depends - lines of ES cells that are deficient for p27. In general, embryoid bodies their differentiation. The changes in levels and configurations of c...

EB - Genetika a molekulární biologie

  • 2003 - 2003
    • •
  • 375 tis. Kč
    • •
  • 280 tis. Kč
    • •
  • AV ČR
Project

Fluctuation of the stem cell niche as a source of tissue adaptability in health and disease (GA23-06160S)

, naturally enabled by stem cells. Although a considerable effort has been devoted to the utilization of stem cells in tissue engineering, the understanding of the real nature of stem cells in adu...

Developmental biology

  • 2023 - 2025
    • •
  • 8 981 tis. Kč
    • •
  • 8 981 tis. Kč
    • •
  • GA ČR
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