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5 074 (0,134s) •

Project

The establishment of advanced cell therapy for the treatment of limbal stem cell deficiency in the Czech Republic. (TO01000099)

To introduce treatment for a blinding corneal disorder, limbal stem cell deficiency (LSCD), using advanced stem cell-based transplantation therapy into clinical practice. First, a xenogeneic-free protocol ...

Ophthalmology

  • 2021 - 2024
    • •
  • 22 031 tis. Kč
    • •
  • 17 631 tis. Kč
    • •
  • TA ČR
Project

Treatment of severe ocular surface injuries using limbal and mesenchymal stem cells (GA14-12580S)

a limbal region, where limbal stem cells (LSC) responsible for corneal epithelium sources of stem cells, such are mesenchymal stem cells (MSC), and on the use of in vitro expand...

FF - ORL, oftalmologie, stomatologie

  • 2014 - 2016
    • •
  • 5 930 tis. Kč
    • •
  • 5 930 tis. Kč
    • •
  • GA ČR
Project

Tissue engineering of genetically competent corneal and conjunctival cells for subsequent grafting in human medicine (7F14156)

of corneal, limbal and conjunctival cells for potential grafting, and will investigate alternative approaches to prolong the "shelf-life" of cells and tissue intended......

FF - ORL, oftalmologie, stomatologie

  • 2014 - 2017
    • •
  • 22 712 tis. Kč
    • •
  • 22 712 tis. Kč
    • •
  • MŠMT
Project

Targeted differentiation and transdifferentiation of limbal and mesenchymal stem cells and their therapeutic applications in preclinical models (GAP304/11/0653)

Stem cells (SC) share a unique property to differentiate or even transdifferentiate into multiple cell types. This makes them an extremely promising tool is healedby cells that originate from SC located in the limb...

FP - Ostatní lékařské obory

  • 2011 - 2014
    • •
  • 6 904 tis. Kč
    • •
  • 6 904 tis. Kč
    • •
  • GA ČR
Project

Anterior eye segment hypoxia and post-hypoxic injury. The role of oxidative stress. Attempts at the development of effective therapies. (GA304/06/1379)

central, peripheral parts of the cornea and limbal area in relation to limbal stem cells and their role in reparative processes. We suggest that oxidative stress plays......

FF - ORL, oftalmologie, stomatologie

  • 2006 - 2008
    • •
  • 4 991 tis. Kč
    • •
  • 4 991 tis. Kč
    • •
  • GA ČR
Project

Fluctuation of the stem cell niche as a source of tissue adaptability in health and disease (GA23-06160S)

, naturally enabled by stem cells. Although a considerable effort has been devoted to the utilization of stem cells in tissue engineering, the understanding of the real nature of stem cells in adu...

Developmental biology

  • 2023 - 2025
    • •
  • 8 981 tis. Kč
    • •
  • 8 981 tis. Kč
    • •
  • GA ČR
Project

Transformations of the gastrointestinal stem cell niche during the development and regeneration (GA21-26025S)

. Surprisingly, the processes driving this stem cell transformation remain unknown the transformation of the embryonic intestinal epithelial stem cells to adult ones at the level of the intestinal stem

Cell biology

  • 2021 - 2023
    • •
  • 8 487 tis. Kč
    • •
  • 8 487 tis. Kč
    • •
  • GA ČR
Project

The use of stem cells in the treatment of amyotrophic lateral sclerosis (GAP304/11/0189)

stem cells and neural stem cells to modify the course of neurodegeneration in a rat model of ALS. Stem cells will be implanted in three different ways - intrathecally, intraspinally and intraveno...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2014
    • •
  • 9 984 tis. Kč
    • •
  • 9 984 tis. Kč
    • •
  • GA ČR
Project

Isolation, cultivation, differentiation and phenotypic characterization of dental pulp stem cells (NR9182)

I. Project is aimed at isolation of stem cells from the dental pulp expansion of these stem cells we plan to use the method of cultivation of human mesenchymal bonemarrow stem cells. III. Dissocia...

EA - Morfologické obory a cytologie

  • 2007 - 2009
    • •
  • 3 084 tis. Kč
    • •
  • 2 894 tis. Kč
    • •
  • MZ
Project

Activation of Chk1 and Chk2 kinases in response to stress in mouse embryonic stem cells. (NR9508)

Study of activation of Chk1 and Chk2 kinases in G1 checkpoint in mouse embryonic stem cells. Characterization of kinases involved in regulation of G1 checkpoint in mouse embryonic stem cells. Study of influence of ...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 2 774 tis. Kč
    • •
  • 2 771 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 5 074