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27 (0,074s) •

Project

Ion Exchanger Catalysts with Increased Lipophilicity (GA104/94/0749)

CF - Fyzikální chemie a teoretická chemie

  • 1994 - 1996
    • •
  • 1 042 tis. Kč
    • •
  • 1 803 tis. Kč
    • •
  • GA ČR
Project

Electrochemical and analytical aspects of the transport of addictive and psychotropic drugs across the model biological barriers (GA20-07350S)

(simulating blood, plasma and other cellular systems) to the hydrophobic (lipophilic versa. Evaluation of the lipophilicity of ionic and neutral drug forms, estimation......

Organic chemistry

  • 2020 - 2023
    • •
  • 9 384 tis. Kč
    • •
  • 9 384 tis. Kč
    • •
  • GA ČR
Project

Characterization and optimisation of separation selectivity for development of new chromatographic and electromigration separation methods (GA203/01/0238)

We will investigate new approaches for characterisation of separation selectivity in HPLC and in various electrically driven separation systems with pseudo-stationary phases, using lipophilic and polarity indices New tests will be developed ...

CB - Analytická chemie, separace

  • 2001 - 2003
    • •
  • 3 245 tis. Kč
    • •
  • 2 495 tis. Kč
    • •
  • GA ČR
Project

Development of new generation of antitumor immunotherapeutics (TA02010760)

Subject of the project is pre-clinical research of the lipophilic analogs of normuramylglycopeptides protected by international patent application (PCT) as immunotherapeutics for the treatment of various types of cancer and development of te...

CC - Organická chemie

  • 2012 - 2015
    • •
  • 28 480 tis. Kč
    • •
  • 17 170 tis. Kč
    • •
  • TA ČR
Project

*New procedures of the lipid micro- and nanodispersion systems formulation as the transport systems of pharmacological active substances (2A-1TP1/015)

*The aim of the project is to indroduce new technological procedures of lipid emulsions and solid lipid nanodispersion formulation and to utilize them as carriers of drugs mainly for per oral and topical administrations.......

JP - Průmyslové procesy a zpracování

  • 2006 - 2011
    • •
  • 15 011 tis. Kč
    • •
  • 9 201 tis. Kč
    • •
  • MPO
Project

Modelling of potentially antimycobacterial active compounds (1A8238)

Tuberculosis is the leading cause of death in the world from a single infectious disease. The problem arising due to MDR-TB requires the development of new agents that have better or a unique mechanism of action, different from the currently used. At...

FR - Farmakologie a lékárnická chemie

  • 2004 - 2006
    • •
  • 1 651 tis. Kč
    • •
  • 1 646 tis. Kč
    • •
  • MZ
Project

Study of polymorphism and nanocompositions of lipophilic Pt(IV) complex TU31 (FW03010522)

The aim of the project is to develop two new prototypes of a new antitumor agent – a drug substance and an oral dosage form of the substance. This will be achieved via significant improving of drug solubility, thus improving its bioavailability, wher...

Medicinal chemistry

  • 2021 - 2023
    • •
  • 9 990 tis. Kč
    • •
  • 4 004 tis. Kč
    • •
  • TA ČR
Project

Autoimmune diseases and nitric oxide - pharmacotherapeutic aspects (GA307/97/0069)

), will be investigated. We showed recently that the lipophilic prodrug of a prototype compound, 9-(2...

FR - Farmakologie a lékárnická chemie

  • 1997 - 1999
    • •
  • 5 068 tis. Kč
    • •
  • 3 145 tis. Kč
    • •
  • GA ČR
Project

Design and enzyme targeting of antibacterial active compounds against multidrug resistant strains (NT13346)

the lipophilic mycobacterial membrane, pharmacogenomics, cloning enzymes and their use...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2015
    • •
  • 8 054 tis. Kč
    • •
  • 8 054 tis. Kč
    • •
  • MZ
Project

Cardiovascular, Potentially Cardioprotective and Biotransformational Effects of New Iron Chelating Agents. (GA305/03/1511)

-chelating agents. These lipophilic substances cross biological membranes, posses high Fe...

FR - Farmakologie a lékárnická chemie

  • 2003 - 2005
    • •
  • 3 445 tis. Kč
    • •
  • 3 445 tis. Kč
    • •
  • GA ČR
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