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101 (0,129s) •

Project

The role of microbiome in pathogenesis of intraocular, systemic and central nervous system lymphoma (NU20-03-00253)

Microenvironment plays a significant role in the lymphoma pathogenesis and the intestinal microbiota, it is not surprising that some lymphomas such as mucosa-associated lymphoid tissue, i.e. MALT gastric lymphoma have been ...

General and internal medicine

  • 2020 - 2023
    • •
  • 17 369 tis. Kč
    • •
  • 17 369 tis. Kč
    • •
  • MZ
Project

Complex analysis of p53 tumor suppressor in non-Hodgkin´s lymphomas (NR9305)

The aim of this project is complex analysis of tumor suppressor p53 in tumor tissue of patients with diffuse large B-cell lymphoma and mantle cell lymphoma to verify whether p53 abberation is useful prognostic marker of the diseases...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 2 494 tis. Kč
    • •
  • 2 494 tis. Kč
    • •
  • MZ
Project

Single-cell transcriptomics for the analysis of subclonal heterogeneity and clonal evolution of mantle cell lymphoma (GA23-05377S)

Mantle cell lymphoma (MCL) is a chronically relapsing malignancy. Molecular mechanisms associated with MCL relapse are still only partially understood. Lymphoma cell established lymphoma cell lines and PDXs derived from one...

Hematology

  • 2023 - 2025
    • •
  • 15 740 tis. Kč
    • •
  • 15 716 tis. Kč
    • •
  • GA ČR
Project

Diffuse large B-cell and follicular lymphoma - the analysis of prognostic factors and therapeutic strategies on patient´s outcome; Lymphoma Project in the Czech Republic. (NT12193)

large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in the Czech Republic will be performed on Czech Lymphoma Study Group registry cohort of approx. 4000 patients. The ultimate goal of the project is to describe “re...

FD - Onkologie a hematologie

  • 2011 - 2015
    • •
  • 6 992 tis. Kč
    • •
  • 6 864 tis. Kč
    • •
  • MZ
Project

Immunological characteristics of lymphomas in childhood (NS10480)

Flow cytometry is an important and fast method in diagnostic process of hematological malignancies. We will analyze by flow cytometry tumor cells and composition of non malignant background in children with lymphomas. The findings will be co...

FG - Pediatrie

  • 2009 - 2011
    • •
  • 6 340 tis. Kč
    • •
  • 6 340 tis. Kč
    • •
  • MZ
Project

Modulation of cyclin-dependent kinases for targeted treatment of tumors with molecularly defined deregulation G1/S phase of cell cycle (GA20-25308S)

in aggressive lymphomas. Inhibition of CDK4/6 makes sense in lymphomas where the type D, CDK4 amplification, or where CDKN2A deletions (mantle cell lymphoma, diffuse large B-cell lymphoma, Burkytt's lymphoma

Medicinal chemistry

  • 2020 - 2022
    • •
  • 9 640 tis. Kč
    • •
  • 9 640 tis. Kč
    • •
  • GA ČR
Project

Follicular dentritic cells in non-Hodgkin lymphomas - diagnostic significance (NC6037)

Follicular dendritic cells remain partly preserved in some lymphomas.Their numbers,patterns of distribution and immunophenotype may be characteristic for different types of lymphomas,an thus can assist in differential diagnosis.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 606 tis. Kč
    • •
  • 585 tis. Kč
    • •
  • MZ
Project

Complex immunohistochemical and molecular biolgic diagnostic of large cell malignant lymphomas with clinicopathological correlation. (NC6296)

Diffuse large cell lymphomas are characterized by specific immunohistochemical and molecular marks.Their genesis is unclear.In this study we shall try to delineate the origin of these lesions and to relate it to the prognosis. We shall use l...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 2 778 tis. Kč
    • •
  • 2 778 tis. Kč
    • •
  • MZ
Project

Therapy intensification of patients with Diffuse Large B Cell Lymphomas based on early FDG-PET positivity (prospective analysis) and retrospective evaluation of the changes in lymphoma therapy (NR9453)

The aim of the project is the analysis of different lymphoma subgroups (follicular, marginal zone, peripheral T cells) and the description of clinical features with Non-Hodgkin´s lymphomas in Czech republic within last 15 years. The...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 6 575 tis. Kč
    • •
  • 6 360 tis. Kč
    • •
  • MZ
Project

Novel mechanisms of lymphomagenesis the role of PHIP protein and its signaling (GJ20-01969Y)

Follicular lymphoma (FL) is the most common indolent type of non-Hodgkin lymphoma. Mutations of epigenetic regulators are critical for FL development. Genomes genomic approach identified novel candidate lymphoma driver gene...

Cell biology

  • 2020 - 2023
    • •
  • 8 365 tis. Kč
    • •
  • 8 365 tis. Kč
    • •
  • GA ČR
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