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159 (0,088s) •

Project

The role of M4 muscarinic receptors in biorhythm regulation (GA17-03847S)

M4 MR inhibit striatal and mesolimbic dopamine release affecting motor coordination. We have found biorhythm changes in female (not male) motor activity in M4 KO animals. The present project will focus on possible role of M4

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2019
    • •
  • 5 347 tis. Kč
    • •
  • 5 278 tis. Kč
    • •
  • GA ČR
Project

Identification of the subtypes and study of genetic variants of HIV-1 in the Czech Republic (NI5174)

Genetic characterization of HIV-1 strains in the Czech Republic. Determination of genetic subtypes, strains resistant to antiretroviral therapy. Comparison of genotypes of the selected HIV-1 strains with their biological properties.......

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 3 095 tis. Kč
    • •
  • 1 374 tis. Kč
    • •
  • MZ
Project

Typing and subtyping of thermophilic Campylobacter spp. strains originated from slaughtered poultry and pigs (OC NA.002)

The occurrence of thermophilic strains of Campylobacter spp. will be monitored. The strains of Campylobacter spp. will received at slaugter from slaughtered pigs and poultry.Isolated strains will subtyped by using molecular methods (PCR, RFL...

GM - Potravinářství

  • 2001 - 2006
    • •
  • 3 150 tis. Kč
    • •
  • 1 810 tis. Kč
    • •
  • MŠMT
Project

Analysis of S.typhimurium-caused salmonelloses in selected localities of the Czech Republic using subtyping methods (NH6083)

The introduction of a suitable system of STM subtyping will enable a more detailed identification of strains for epidemiological purposes. In selected localities clinical isolates will be collected, accompanied with sheets of epidemiological...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 5 361 tis. Kč
    • •
  • 1 433 tis. Kč
    • •
  • MZ
Project

Correlation of molecular biological, immunohistochemical and clinical characteristics of diffuse large B cell lymphoma in terms of diagnostical and prognostic algorithm. (NS9791)

Retrospectively, the expression of selected genes in patients with DLBCL will be studied from FFPE (formalin fixed, paraffin embedded) tissue. The results will be compared with immunohistochemical findings (GC and nonGC subtypes) and with cl...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 4 569 tis. Kč
    • •
  • 4 569 tis. Kč
    • •
  • MZ
Project

Utilization of modern biotechnologies - multiplex molecular analysis (xMAP) for development of diagnostic sets for detection and typing of human papilomavirus subtypes (HPV). (FI-IM3/083)

Development of diagnostic sets for detection and subtyping of papillomaviruses (HPV) as a predictive oncology marker of cervical cancer. These diagnostic sets willutilize multiplex molecular biotechnologies (PCR and xMAP), which enables anal...

FD - Onkologie a hematologie

  • 2006 - 2009
    • •
  • 28 794 tis. Kč
    • •
  • 12 915 tis. Kč
    • •
  • MPO
Project

Analysis of signalling bias of novel synthetic muscarinic agonists (GJ19-06106Y)

of five subtypes with distinct localization and signalling profile. To avoid undesired side effects a selective modulation of individual muscarinic subtypes is necessary. Due to high homology of the orthosteric binding site among i...

Pharmacology and pharmacy

  • 2019 - 2022
    • •
  • 4 246 tis. Kč
    • •
  • 4 246 tis. Kč
    • •
  • GA ČR
Project

Effects of glucocorticoids on M1 and M2 muscarinic receptor subtypes and newly defined adrenoceptor subtype beta4 in rat heart (GA309/00/D031)

The project will contribute to the understanding of the mechanisms of neural and humoral regulation of cardiac activity. The effect of glucocorticoid hormones on neurotransmitter receptors in the heart will be investigated, concentrating on the newly...

FH - Neurologie, neurochirurgie, neurovědy

  • 2000 - 2003
    • •
  • 852 tis. Kč
    • •
  • 711 tis. Kč
    • •
  • GA ČR
Project

Protective role of antimeningococcal antibodies group type and subtype specific. (IZ1624)

9F - 9

  • 1993 - 1995
    • •
  • 250 tis. Kč
    • •
  • 500 tis. Kč
    • •
  • MZ
Project

The support of results and participation in organisations for taxonomy of Listeria and subtyping of L. monocytogenes (PG96131)

9A - 9

  • 1996 - 1996
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 159