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104 (0,072s) •

Project

Structural and functional study of matrix protein and proteinaseof monkey immunosuppressive retrovirus (GA203/97/0416)

in M-PMV matrix protein (MA) can alter the morphogenesis of D-type to that of C, structural comparison of MA of both morphogenetic types could elucidate the mechanism. The structure of purified protein will be studied and compared ...

CE - Biochemie

  • 1997 - 1999
    • •
  • 2 843 tis. Kč
    • •
  • 1 809 tis. Kč
    • •
  • GA ČR
Project

Determination of critical developmental period for methamphetamine effects in rats (GA14-03708S)

Methamphetamine (MA) is a frequently abused drug in pregnant drug-abusing women of the offspring. Although many studies showed impairing effects of maternal MA injection in pregnant women addicted to MA. Within the planned ...

FH - Neurologie, neurochirurgie, neurovědy

  • 2014 - 2016
    • •
  • 5 032 tis. Kč
    • •
  • 5 032 tis. Kč
    • •
  • GA ČR
Project

The effect of mutations and morphogenetic differences in matrix proteins on assembly and transport of retroviral capsids (GA203/98/P151)

Matrix protein (MA) of Mason-Pfizer monkey virus (M-PMV), which is the prototype of the type D retroviruses, plays a critical role in retroviral replication cycle. A mutant of MA, which changes morphogenetic type D to that of C of m...

CE - Biochemie

  • 1998 - 2000
    • •
  • 822 tis. Kč
    • •
  • 703 tis. Kč
    • •
  • GA ČR
Project

Does prenatal methamphetamine exposure induce cross-sensitization to drugs in adult male and female rats? (GA305/09/0126)

is methamphetamine (MA), which is also the most frequently abused illicit drug in the Czech Republic. Our previous studies demonstrated that prenatal MA exposure alters behavior studies demonstrate that prenatal MA exposur...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2013
    • •
  • 5 487 tis. Kč
    • •
  • 5 487 tis. Kč
    • •
  • GA ČR
Project

Study of relationships between structure and function of phenotypically relevant mutants of Mason-Pfizer monkey virus matrix protein (GA203/03/0490)

of phenotypically relevant mutants of retroviral matrix protein (MA), which is common to all replication competent viruses. MA protein forms the outer protein shell of a mature virion of MA leading to changes in morphogene...

CE - Biochemie

  • 2003 - 2005
    • •
  • 5 104 tis. Kč
    • •
  • 3 346 tis. Kč
    • •
  • GA ČR
Project

Role of retroviral matrix protein in virus particle targeting and interaction with plasma membrane. (GAP302/12/1895)

with the cytoplasmic membrane. We aim to study the retroviral matrix protein (MA), a key triggered by the interaction of MA with the phosphoinositide components of plasma of phosphoinositide liposomes to study their interactions wi...

EE - Mikrobiologie, virologie

  • 2012 - 2016
    • •
  • 8 835 tis. Kč
    • •
  • 8 835 tis. Kč
    • •
  • GA ČR
Project

Sensitization induced by prenatal methamphetamine exposure in adult rats (GA305/06/0283)

by pregnant women is methamphetamine (MA), which is also one of the most frequently used illicit drug in the Czech Republic. Our previous studies demonstrated that prenatal MA in adult rats. To extend our previous results we were i...

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2008
    • •
  • 3 861 tis. Kč
    • •
  • 3 861 tis. Kč
    • •
  • GA ČR
Project

Active drug-seeking behavior in prenatally methamphetamine-exposed adult male and female rats (NS10509)

methamphetamine (MA) exposure on drug-seeking behavior in adulthood. The following drugs will be tested: (1) the same drug as prenatally (MA); (2) the related drugs (amphetamine is the first to test the hypothesis that prenatal

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2011
    • •
  • 3 151 tis. Kč
    • •
  • 3 151 tis. Kč
    • •
  • MZ
Project

Big stones in settlements Social strategies and macrolithic artefacts during the Neolithic and the Chalcolithic in Anatolia (GA22-10930S)

, will be so-called macrolithic artefacts (MA). The three sites under study – Tepecik functional groups of MA correspond to the segmentation of the settlement area based on other material indicators? 2) Which particular MA ...

Archaeology

  • 2022 - 2024
    • •
  • 1 966 tis. Kč
    • •
  • 1 966 tis. Kč
    • •
  • GA ČR
Project

Impact of different environments on cognitive functions of adolescent male rats exposed prenatally to methamphetamine (GA18-03806S)

Children prenatally exposed to methamphetamine (MA), one of the most commonly to unfavorable health and social conditions. Using animal models, we demonstrated that MA is the most vulnerable to MA exposure. Adverse effects ...

Neurosciences (including psychophysiology)

  • 2018 - 2020
    • •
  • 9 847 tis. Kč
    • •
  • 9 484 tis. Kč
    • •
  • GA ČR
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