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3 (0,056s)

Project

Targeted inhibition of BCL2 family proteins in experimental therapy of diffuse large B-cell lymphoma (DLBCL) (NV15-27757A)

-Hodgkin lymphomas (NHL) in the Western hemisphere. BCL2 and MCL1 belong to key with poor prognosis in DLBCL. MCL1 was recently reported overexpressed in part of DLBCL clinically in diverse B-cell malignancies. Homoharringtonine (HH...

FD - Onkologie a hematologie

  • 2015 - 2018
  • 6 991 tis. Kč
  • 6 991 tis. Kč
  • MZ
Project

Tumor-microenvironment responsive nanomedicines as multistage drug delivery systems for experimental therapy of hematologic malignancies (GA19-01417S)

of cytotoxic drugs, inhibitors of anti-apoptotic proteins BCL2 and MCL1 (venetoclax, S63845...

Hematology

  • 2019 - 2021
  • 7 703 tis. Kč
  • 7 616 tis. Kč
  • GA ČR
Project

Molecular base for therapy with BH3 mimetics to overcome refractory/relapsed Ph+ leukemias (NW24-03-00056)

on the antiapoptotic proteins BCL2 and MCL1. The efficacy of combination therapy with BCL2 and MCL1...

Oncology

  • 2024 - 2027
  • 17 555 tis. Kč
  • 16 386 tis. Kč
  • MZ
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