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Project

Biophysical method of monitoring the activity of multidrug resistance systems and membrane potential changes in yeast cells (GAP205/10/1121)

a fluorometric assay for testing the activity of MDR pumps in yeast cells that has substrates of MDR pumps in experiments performed with yeast cell suspensions, and ii)identification of MDR pump inhibitors, and iii) the st...

BO - Biofyzika

  • 2010 - 2012
    • •
  • 1 928 tis. Kč
    • •
  • 1 928 tis. Kč
    • •
  • GA ČR
Project

Complex analysis of role of MDR1 gene in breast tumor resistance (GP305/07/P347)

Multidrug  resistance (MDR) of tumor cells to cytotoxic drugs is one of MDR. The aimof this study is to determine presence of single-nucleotide of MDR, grade of disease and success of breast cancer chemotherapy. Simultaneou...

CE - Biochemie

  • 2007 - 2009
    • •
  • 1 471 tis. Kč
    • •
  • 1 471 tis. Kč
    • •
  • GA ČR
Project

Identification of new diagnostic/predictive biomarkers and compounds applicable to personalized treatments of multidrug resistant tumors (LTC19020)

and their function will be studied in MDR cancer cell lines. Novel potential MDR-reversal agents (Stony Brook Taxanes) applicable in MDR tumors will be investigated.......

Human genetics

  • 2019 - 2022
    • •
  • 3 936 tis. Kč
    • •
  • 3 936 tis. Kč
    • •
  • MŠMT
Project

Evolution of emergent multidrug resistant Streptococcus pneumoniae 19A serotype in era of pneumococcal vaccination. (NV16-27109A)

. A major concern is the occurence of multidrug-resistant (MDR) pneumococci. As the pneumococcal conjugate vaccines target most of MDR serotypes, it was postulated that introduction of vaccination would reverse the success MDR

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2016 - 2019
    • •
  • 8 566 tis. Kč
    • •
  • 8 071 tis. Kč
    • •
  • MZ
Project

Rare and uncommon flavonolignans Chemo-enzymatic preparation and pharmacological activity (GA18-00150S)

signalization, and their inhibitory activities towards multi-drug resistance (MDR) proteins that will be evaluated in detail for MDR modulatory activity and their cytotoxicity.......

Biochemical research methods

  • 2018 - 2020
    • •
  • 7 591 tis. Kč
    • •
  • 6 859 tis. Kč
    • •
  • GA ČR
Project

MDR pumps in yeast kinetics, inhibition and the role of various physiological conditions;Dis-C3(3) fluorescence assay (GP202/04/P110)

for the determination of the activity of membrane-integrated MDR-pumps (Multi-Drug Resistance organism. The MDR-pumps activity will be studied in yeast grown in liquid media the pump activity. Various inhibitors of MDR-pum...

BG - Jaderná, atomová a molekulová fyzika, urychlovače

  • 2004 - 2006
    • •
  • 628 tis. Kč
    • •
  • 628 tis. Kč
    • •
  • GA ČR
Project

Natural polyphenolic compounds for adjunct tumor treatment combined with MDR inhibition (LTC20070)

The objectives of the present project are to participate to the WG2 of the COST Action CA17104 STRATAGEM by synthesizing, through a rational design, a small library of natural flavonoids and flavonolignans and their derivatives with MDR-inhi...

Organic chemistry

  • 2020 - 2022
    • •
  • 4 132 tis. Kč
    • •
  • 4 132 tis. Kč
    • •
  • MŠMT
Project

The influence of gene variability on the bioavailability of immunosuppressiv drugs and its relation to the short-term and long-term outcome of kidney transplantation (NR8816)

Observation of the influence of polymorphisms in CYP3A4, CYP3A5 and MDR-1 genes on the metabolism of immunosuppressive drugs in kidney transplant recipients. Observation of effect of polymorphisms in CYP3A4, CYP3A5 and MDR-1 genes o...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 3 375 tis. Kč
    • •
  • 3 071 tis. Kč
    • •
  • MZ
Project

Study on the role of novel targeted breast and lung anticancer drugs in the phenomenon of pharmacokinetic drug resistance (GJ20-20414Y)

Breast and lung cancer belong to the most frequent causes of morbidity and mortality within oncological diseases worldwide. Multidrug resistance (MDR) represents MDR mechanisms so far. In this project, we aim to study interactions o...

Pharmacology and pharmacy

  • 2020 - 2022
    • •
  • 4 909 tis. Kč
    • •
  • 4 869 tis. Kč
    • •
  • GA ČR
Project

Genomic analysis of antibiotic multiresistance in a global epidemic clone of Acinetobacter baumannii. (NT14466)

Acinetobacter baumannii is an important bacterial pathogen causing intractable hospital infections. The escalating global problem of its multiple drug resistance (MDR is to identify the genetic factors responsible for the ongoing development...

EE - Mikrobiologie, virologie

  • 2013 - 2015
    • •
  • 2 975 tis. Kč
    • •
  • 2 928 tis. Kč
    • •
  • MZ
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