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107 (0,189s) •

Project

Importance of miRNA deregulation in myelodysplastic syndromes and in other hematological clonal diseases (GP301/09/P579)

Myelodysplasic syndrome (MDS) is a family of heterogeneous blood disorders. An intensive research has been focused on MDS pathogenesis and cytogenetic aberrations associated with approx. 50% of MDS have been revealed; howev...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 1 546 tis. Kč
    • •
  • 1 546 tis. Kč
    • •
  • GA ČR
Project

The molecular markers in diagnostics and therapy-monitoring of myelodysplastic syndrome patients treated by new modalities. (NV16-27790A)

Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoiesis myeloid leukemia (AML). In MDS, the somatic mutations were recently found to precede MDS pathogenesis already in normal individuals. Furthermore, their ac...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 12 498 tis. Kč
    • •
  • 12 498 tis. Kč
    • •
  • MZ
Project

DNA - diagnosis of Myotonic Dystrophy. (NE5916)

The study introducing molecular genetic diagnostic of myotonic dystrophy (MD) for czech patients.The diagnostic is based on negative selection of Md patients by nonradioactie PCR and conseqently,by RFLP to detect a MD diagn...

FH - Neurologie, neurochirurgie, neurovědy

  • 2000 - 2002
    • •
  • 1 529 tis. Kč
    • •
  • 1 519 tis. Kč
    • •
  • MZ
Project

Diagnostics and treatment of myelodysplastic syndrome in children. (NE5676)

The aim of the study is to improve the accuracy of diagnosis for children with MDS by a standardized review of morphology and standard cytogenetic nad molecular analyses. Participation in the international multicentric study offers to childr...

FD - Onkologie a hematologie

  • 1999 - 2002
    • •
  • 1 285 tis. Kč
    • •
  • 1 285 tis. Kč
    • •
  • MZ
Project

Circular RNAs and their relation to RNA splicing in the pathogenesis of myelodysplastic syndromes (GA20-19162S)

alterations in myelodysplastic syndromes (MDS). Despite some advances in the understanding of their roles in MDS pathogenesis, the impact of mutated splicing factors on circular RNAs that the aberrant splicing seen in MDS ...

Human genetics

  • 2020 - 2023
    • •
  • 9 979 tis. Kč
    • •
  • 9 687 tis. Kč
    • •
  • GA ČR
Project

Clinically relevant substrates of proteasome degradation in MDS. (NU21-08-00312)

Myelodysplastic syndromes (MDS) represent disease entity of clonal analyses indicate how fast will MDS progress to acute myeloid leukemia (AML). A special category represents MDS with deletion of chromosome 5q. A prototype ...

Biochemistry and molecular biology

  • 2021 - 2024
    • •
  • 12 919 tis. Kč
    • •
  • 12 919 tis. Kč
    • •
  • MZ
Project

ROLE OF CYTOKINE PRIMING IN AZACITIDINE-MEDIATED LEUKEMIA STEM CELL DIFFERENTIATION IN THERAPY OF PROGRESSING MYELODYSPLASIA (GA18-01687S)

Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoiesis blockades of cell differentiation. Patients with MDS suffer with cytopenias clonal myeloblasts. Treatment of MDS patients with DNA-methylation inhibitor ...

Oncology

  • 2018 - 2020
    • •
  • 10 226 tis. Kč
    • •
  • 10 082 tis. Kč
    • •
  • GA ČR
Project

Application of high-throughput technologies for screening of plasma circulating microRNAs in myelodysplastic syndromes (NV16-33617A)

their deregulation in myelodysplastic syndromes (MDS). Nowadays, the diagnosis of MDS is based samples from MDS patients. Comparison of plasma miRNA profiles i) in untreated MDS patients with various disease subty...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 7 861 tis. Kč
    • •
  • 7 861 tis. Kč
    • •
  • MZ
Project

TraiN-SafeMDs Training Network for improving knowledge on safety of medical devices - focus on oral cavity (8X20026)

Medical devices (MDs) have irreplaceable role in modern healthcare. The term disabilities or injuries. MDs used in the oral cavity are usually those helping materials and dental prosthetic devices are also an important group of ...

Public and environmental health

  • 2020 - 2022
    • •
  • 236 tis. Kč
    • •
  • 236 tis. Kč
    • •
  • MŠMT
Project

Molecular cytogenetic analysis of complex chromosomal aberrations in bone marrow cells of patients with myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML) and AND its contribution (NR9227)

Molecular cytogenetic analysis of complex chromosomal aberrations in patients with MDS and AML. Identification of chromosomes and/or chromosomal regions involved in complex karyotypes. Evaluation of the impact of complex rearrangements on pr...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 3 054 tis. Kč
    • •
  • 2 953 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 107