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145 (0,102s) •

Project

Molecular cytogenetic analysis of complex chromosomal aberrations in bone marrow cells of patients with myelodysplastic syndrome (MDS) and/or acute myeloid leukemia (AML) and AND its contribution (NR9227)

Molecular cytogenetic analysis of complex chromosomal aberrations in patients with MDS and AML. Identification of chromosomes and/or chromosomal regions involved in complex karyotypes. Evaluation of the impact of complex rearrangeme...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 3 054 tis. Kč
    • •
  • 2 953 tis. Kč
    • •
  • MZ
Project

ROLE OF CYTOKINE PRIMING IN AZACITIDINE-MEDIATED LEUKEMIA STEM CELL DIFFERENTIATION IN THERAPY OF PROGRESSING MYELODYSPLASIA (GA18-01687S)

Myelodysplastic syndrome (MDS) is a clonal disorder of hematopoiesis blockades of cell differentiation. Patients with MDS suffer with cytopenias and ineffective hematopoiesis while upon progression to AML, the bone marrow b...

Oncology

  • 2018 - 2020
    • •
  • 10 226 tis. Kč
    • •
  • 10 082 tis. Kč
    • •
  • GA ČR
Project

The molecular markers in diagnostics and therapy-monitoring of myelodysplastic syndrome patients treated by new modalities. (NV16-27790A)

myeloid leukemia (AML). In MDS, the somatic mutations were recently found to precede MDS pathogenesis already in normal individuals. Furthermore, their accumulation mark a progression towards AML. Abnormal epigene...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 12 498 tis. Kč
    • •
  • 12 498 tis. Kč
    • •
  • MZ
Project

Instability of the genome of bone marrow cells of patients with AML and MDS. (OC10043)

The aim of our study in cooperation with COST projecBM0801 is to analyse chromosomal changes in complex karyotypes of patients with MDS and AML in detail using all and significance of these aberrations for disease progression and tr...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 2 100 tis. Kč
    • •
  • 2 100 tis. Kč
    • •
  • MŠMT
Project

The role of RUNX1, EVI1 and CEBPA genes in the pathogenesis of leukemias and pre-leukemias (NR9045)

. Mutations in genes for transcription factor RUNX1 in AML and MDS patients and transcription factor CEBPA in AML patients will be analysed. The elevated level of transcription factor EVI1 mRNA is unfavorable prognostic mar...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 6 857 tis. Kč
    • •
  • 6 492 tis. Kč
    • •
  • MZ
Project

A role of DNA damage response in prediction of prognosis and selection of targeted therapy in patients with MDS and AML (NW25-03-00327)

for novel prognostic and therapeutic approaches to LR-MDS and AML. a tumor-suppressing barrier in lower-risk myelodysplastic neoplasia (LR-MDS), proposed a DDR-related gene signature as an independent predictor for prognos...

Oncology

  • 2025 - 2028
    • •
  • 12 536 tis. Kč
    • •
  • 12 536 tis. Kč
    • •
  • MZ
Project

Genetic Analysis of Candidate Genes in Acute Myeloid Leukemias and Myelodyplastic Syndromes (NC5535)

We will characterize candidate suppressor genes from the region of chromosome-5q deletions in myeloid malignancies with particular focus on regulation of S mad5 expression and isolation of genes with distinct expression patterns in cells with del(5q)...

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 4 419 tis. Kč
    • •
  • 4 394 tis. Kč
    • •
  • MZ
Project

Molecular characteristic of childhood acute myeloid leukemia and myelodysplastic syndrome (OC09051)

and stratification of childhood AML and MDS. We will test the potential of polychromatic flow in the diagnosis and follow-up of childhood AML and MDS. In vitro we will apply valproic acid as a new treatment modali...

FD - Onkologie a hematologie

  • 2009 - 2012
    • •
  • 3 234 tis. Kč
    • •
  • 2 450 tis. Kč
    • •
  • MŠMT
Project

Application of DNA methylation arrays for assessment of aberrantly methylated genes in MDS and AML patients (OC10042)

(MDS) and acute myeloidleukemia (AML). We will choose the panel of the most...

FD - Onkologie a hematologie

  • 2010 - 2012
    • •
  • 2 400 tis. Kč
    • •
  • 2 100 tis. Kč
    • •
  • MŠMT
Project

Multifunctional nanostructures for plasmonic sensing of biomolecules related to onco-hematological diseases (GA22-27329S)

of microRNA and protein biomarkers of myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). This goal will be achieved by the development of new multi-functional for the research of onco-hematological diseases, open up ...

Optics (including laser optics and quantum optics)

  • 2022 - 2024
    • •
  • 10 284 tis. Kč
    • •
  • 9 996 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 145