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Projects

55 projects (0,113s) •

Project

Tumours of human papillomavirus origin with different expression of MHC class I molecules theoretical principles of immunotherapy. (NR7807)

In this grant project it will be investigated whether there is a lack of immunological cross-reactivity between MHC class I positive and MHC class I negative tumours supra-treshold levels of the MHC class I molecules. It wi...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 4 218 tis. Kč
    • •
  • 2 404 tis. Kč
    • •
  • MZ
Project

Vaccination against two types (MHC I+ and MHC I-) of tumours induced by E6/E7 HPV16 viral oncogenes. (NC7148)

This grant project is aimed at optimization of the immunotherapeutic protocols in two types of tumours (MHC I+ and MHC I-) induced by HPV16 E6/E7 oncogenes administered separetely or together with dendritic cell-based vaccines. In t...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 5 395 tis. Kč
    • •
  • 3 375 tis. Kč
    • •
  • MZ
Project

The role of MHC in sexual selection - observational and experimental study in three model vertebrate species (IAA600930608)

histocompatibility complex (MHC) in sexual selection. Specifically, the project focus on: (1) the description of the MHC polymorphism levels in three selected model vertebrates; (2) testing the relationships between MHC ge...

EG - Zoologie

  • 2006 - 2008
    • •
  • 3 972 tis. Kč
    • •
  • 3 972 tis. Kč
    • •
  • AV ČR
Project

MHC class IIB genes of European cyprinid fish their genetic variability and evolution in relation to the host life-history traits and parasitism (GA524/04/1128)

Analyses of the major histocompatibility complex genes (MHC) have been part. The MHC presents a group of genes of the highly polymorphic loci encoding the proteins response. Recently, the factors driving and maintaining the extensiv...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 451 tis. Kč
    • •
  • 2 951 tis. Kč
    • •
  • GA ČR
Project

Characterization of the ribosome translating pre-spliced mRNAs for the synthesis of antigenic peptide substrates for the MHC-I pathway (GA23-06884S)

The presentation of antigenic peptides (APs) on MHC-I molecules is essential that MHC-I APs are produced by a non-canonical mRNA translation event that is distinct data show that translation of pre-spliced mRNAs produces MHC

Immunology

  • 2023 - 2025
    • •
  • 10 603 tis. Kč
    • •
  • 10 357 tis. Kč
    • •
  • GA ČR
Project

Immunotherapy of MHC class I - Tumours Modulation of the MHC Class I Expression by Demethylation, Selection of Proper Adjuvants (GA301/04/0492)

response,which are dependent on the expression of MHC class I molecules on tumour cells, and to develop the anti-tumour immunotherapy. We will induce the expression of the MHC class I molecules on MHC class I negative tumo...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 979 tis. Kč
    • •
  • 2 979 tis. Kč
    • •
  • GA ČR
Project

Gene immunotherapy of tumours with different expression of MHC-I. (NC5900)

Induction of immunity against tumours cells producing HPV16 E7 oncoprotein and differing in the degree of MHC-I expression.Combination of DNA immunization and immunization with transduced tumour cells. Enhancement of immune responses by heat...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 9 325 tis. Kč
    • •
  • 8 670 tis. Kč
    • •
  • MZ
Project

Evolutionary-immunological and ecological aspects of parasitism in hybrid and polyploid cyprinid fish (GAP505/12/0375)

and parasite genotype. The genes of MHC are predicted to co-evolve in associations with specific parasites. 2)The super-optimal individual MHC diversity in hybrids number of different MHC variants in hybrids resulting from...

EH - Ekologie – společenstva

  • 2012 - 2016
    • •
  • 13 256 tis. Kč
    • •
  • 13 256 tis. Kč
    • •
  • GA ČR
Project

Combined immunotherapy of tumors with different expression of MHC class I molecules (GA16-04477S)

This study will focus on the immunotherapy of tumors with reversibly or irreversibly down-regulated surface expression of MHC class I (MHC-I) molecules. In a mouse model of tumors associated with human papillomavirus type 16 (HPV16)...

EC - Imunologie

  • 2016 - 2020
    • •
  • 8 919 tis. Kč
    • •
  • 8 724 tis. Kč
    • •
  • GA ČR
Project

The expression regulation of HSP70 genes – potential molecular marker for monitoring of myositis. (NT13699)

for autoimmunity development is the major histocompatibility complex (MHC). The role of MHC development; nevertheless the role of non class I/II MHC genes is not clear. Beside other and polymorphisms of all three MHC

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 6 867 tis. Kč
    • •
  • 6 867 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 55