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4 773 (0,143s) •

Project

Gene immunotherapy of tumours with different expression of MHC-I. (NC5900)

Induction of immunity against tumours cells producing HPV16 E7 oncoprotein and differing in the degree of MHC-I expression.Combination of DNA immunization and immunization with transduced tumour cells. Enhancement of immune response...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 9 325 tis. Kč
    • •
  • 8 670 tis. Kč
    • •
  • MZ
Project

Immunotherapy of MHC class I - Tumours Modulation of the MHC Class I Expression by Demethylation, Selection of Proper Adjuvants (GA301/04/0492)

response,which are dependent on the expression of MHC class I molecules on tumour cells, and to develop the anti-tumour immunotherapy. We will induce the expression of the MHC class I molecules o...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 979 tis. Kč
    • •
  • 2 979 tis. Kč
    • •
  • GA ČR
Project

Tumours of human papillomavirus origin with different expression of MHC class I molecules theoretical principles of immunotherapy. (NR7807)

In this grant project it will be investigated whether there is a lack of immunological cross-reactivity between MHC class I positive and MHC class I negative tumours supra-treshold levels of the MHC class ...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 4 218 tis. Kč
    • •
  • 2 404 tis. Kč
    • •
  • MZ
Project

Vaccination against two types (MHC I+ and MHC I-) of tumours induced by E6/E7 HPV16 viral oncogenes. (NC7148)

in two types of tumours (MHC I+ and MHC I-) induced by HPV16 E6/E7 oncogenes administered separetely or together with dendritic cell-based vaccines. In the HPV16+,l MHC I-, metastasizing tumour M...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 5 395 tis. Kč
    • •
  • 3 375 tis. Kč
    • •
  • MZ
Project

Combined immunotherapy of tumors with different expression of MHC class I molecules (GA16-04477S)

This study will focus on the immunotherapy of tumors with reversibly or irreversibly down-regulated surface expression of MHC class I (MHC-I) molecules. In a mouse model of tumors associated with human pap...

EC - Imunologie

  • 2016 - 2020
    • •
  • 8 919 tis. Kč
    • •
  • 8 724 tis. Kč
    • •
  • GA ČR
Project

The expression regulation of HSP70 genes – potential molecular marker for monitoring of myositis. (NT13699)

for autoimmunity development is the major histocompatibility complex (MHC). The role of MHC class I and class II molecules is already known in relation to autoimmunity development; nevertheless the role of non class I<...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 6 867 tis. Kč
    • •
  • 6 867 tis. Kč
    • •
  • MZ
Project

Experimental cancer immunotherapy, tumor heterogeneity, and overcoming tumor immune escape (GA19-00816S)

to overcome three tumor escape mechanisms: downregulation of MHC-I expression activity of IDO1. Overcoming MHC-I downregulation will be studied by using clones of mouse oncogenic TC-1 cells with both reve...

Immunology

  • 2019 - 2022
    • •
  • 8 243 tis. Kč
    • •
  • 8 243 tis. Kč
    • •
  • GA ČR
Project

Role of NK, Th and tumour-infiltrating cells in chemotherapy and gene therapy of MHC I-defficient HPV 16-associated tumours (GA301/06/0774)

. to analyse the changes in the expression of surface markers of tumour cells after.chemotherapy and gene therapy (expression of MHC class I molecules), to find out the most advantageous scheme for adjuvant immunot...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 2 760 tis. Kč
    • •
  • 2 760 tis. Kč
    • •
  • GA ČR
Project

Tumour vaccines constructed by fusion of tumour and dendritic cells (IAA5052203)

each otherby expression of MHC I molecules. The vaccines to be compared will be constructed from: (1) tumour cells expressing MHC class I molecules and DC derived from) tumour cellsnon expres...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 2 984 tis. Kč
    • •
  • 2 007 tis. Kč
    • •
  • AV ČR
Project

Mechanisms of protective immunity against tumours with different expression of immunodulatory molecules (IAA500520807)

cells expressing the same oncoproteins E6/E7, but different in the expression of MHC class I and other immunomodulatory molecules, used as cellular vaccines against variants of tumours with different expressio...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 2 800 tis. Kč
    • •
  • 2 800 tis. Kč
    • •
  • AV ČR
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