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2 854 (0,066s) •

Project

The role of MHC in sexual selection - observational and experimental study in three model vertebrate species (IAA600930608)

The project aims at evaluating the function of highly variable genes of major histocompatibility complex (MHC) in sexual selection. Specifically, the project focus on: (1) the description of the MHC polymorphism levels in t...

EG - Zoologie

  • 2006 - 2008
    • •
  • 3 972 tis. Kč
    • •
  • 3 972 tis. Kč
    • •
  • AV ČR
Project

Gene immunotherapy of tumours with different expression of MHC-I. (NC5900)

Induction of immunity against tumours cells producing HPV16 E7 oncoprotein and differing in the degree of MHC-I expression.Combination of DNA immunization and immunization with transduced tumour cells. Enhancement of immune responses by heat...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 9 325 tis. Kč
    • •
  • 8 670 tis. Kč
    • •
  • MZ
Project

MHC class IIB genes of European cyprinid fish their genetic variability and evolution in relation to the host life-history traits and parasitism (GA524/04/1128)

Analyses of the major histocompatibility complex genes (MHC) have been part. The MHC presents a group of genes of the highly polymorphic loci encoding the proteins-contradictious hypotheses used to explain the grea...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 3 451 tis. Kč
    • •
  • 2 951 tis. Kč
    • •
  • GA ČR
Project

The expression regulation of HSP70 genes – potential molecular marker for monitoring of myositis. (NT13699)

development; nevertheless the role of non class I/II MHC genes is not clear. Beside other genes involved in immune response, there are also three heat-shock protein (HSP) 70 and polymorphisms of all three MHC link...

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 6 867 tis. Kč
    • •
  • 6 867 tis. Kč
    • •
  • MZ
Project

Vaccination against two types (MHC I+ and MHC I-) of tumours induced by E6/E7 HPV16 viral oncogenes. (NC7148)

in two types of tumours (MHC I+ and MHC I-) induced by HPV16 E6/E7 oncogenes projectby insertion of IL-2 and GM-CSF genes into HPV16+ tumour cells The research administered separetely or together with dendritic cell-based ...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 5 395 tis. Kč
    • •
  • 3 375 tis. Kč
    • •
  • MZ
Project

Evolutionary-immunological and ecological aspects of parasitism in hybrid and polyploid cyprinid fish (GAP505/12/0375)

and parasite genotype. The genes of MHC are predicted to co-evolve in associations with specific parasites. 2)The super-optimal individual MHC diversity in hybrids number of different MHC variants in hybrids resul...

EH - Ekologie – společenstva

  • 2012 - 2016
    • •
  • 13 256 tis. Kč
    • •
  • 13 256 tis. Kč
    • •
  • GA ČR
Project

Role of NK, Th and tumour-infiltrating cells in chemotherapy and gene therapy of MHC I-defficient HPV 16-associated tumours (GA301/06/0774)

after.chemotherapy and gene therapy (expression of MHC class I molecules), to find out the most advantageous scheme for adjuvant immunotherapy for individual MHC I deficient tumours 2 for combined therapy of tumours lackin...

FD - Onkologie a hematologie

  • 2006 - 2008
    • •
  • 2 760 tis. Kč
    • •
  • 2 760 tis. Kč
    • •
  • GA ČR
Project

The role of immune investment in the context of trade-offs immuno-ecological study of the relationships among reproduction, immunity and parasitism (GA524/07/0188)

complex (MHC) genes is maintained by parasite or pathogen selection was applied in this study. Then, we hypothesize that MHC diversity could represent the "good quality" genes potentially affecting fish vigour and...

EH - Ekologie – společenstva

  • 2007 - 2011
    • •
  • 6 308 tis. Kč
    • •
  • 6 308 tis. Kč
    • •
  • GA ČR
Project

Comparative immunogenomics of the family Equidae (GA523/09/1972)

and balancing selection of the MHC DRB, DQB genes and of the KIR/Ly49 genes, encoding immunity-related genes will be performed in various species of zebras, asses and in two populations of domestic donkeys. Ge...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2009 - 2012
    • •
  • 6 886 tis. Kč
    • •
  • 6 886 tis. Kč
    • •
  • GA ČR
Project

Tumours of human papillomavirus origin with different expression of MHC class I molecules theoretical principles of immunotherapy. (NR7807)

In this grant project it will be investigated whether there is a lack of immunological cross-reactivity between MHC class I positive and MHC class I negative tumours supra-treshold levels of the MHC class I molecules. It wi...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 4 218 tis. Kč
    • •
  • 2 404 tis. Kč
    • •
  • MZ
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