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11 (0,11s) •

Project

The genetic background of the gestation diabetes - the study of the MODY genes (ME 464)

The study of the genetic background of the gestational diabetes - the evaluation of the prevalence of mutations and polymorphisms in MODY genes, esp. in GCK and HNF1alpha, using the TGGE and sequencing. The aim of the study is to find the at...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2001 - 2003
    • •
  • 920 tis. Kč
    • •
  • 500 tis. Kč
    • •
  • MŠMT
Project

Developmental phenotype of patients with MODY diabetes over the life-span (NR9067)

We aim to study somatic, auxological and metabolic phenotype of patients with distinct subtypes of MODY diabetes over the lifespan. The birth weight,growth and development,clinical course of diabetes and risk of diabetic complications will b...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2006 - 2008
    • •
  • 370 tis. Kč
    • •
  • 370 tis. Kč
    • •
  • MZ
Project

Prevalence of known mutations and search for new gene mutations and polymorphisms in patients with MODY diabetes in the Czech Republic. (NB6122)

Known mutations will be estimated and new mutations and polymorphisms will be searched in 5 genes responsible for MODY diabetes by direct gene sequencing. Consequently, genotype-phenotype correlation based on clinical and laboratory data wil...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 2 615 tis. Kč
    • •
  • 2 613 tis. Kč
    • •
  • MZ
Project

Genetic investigation of monogenic diabetes in the Czech Republic Evaluation of clinical symptoms, treatment and quality of life (NT11402)

Monogenic diabetes (mainly the MODY subtype) may affect up to 30,000 people in the Czech Republic. However, only 1% of them are correctly diagnosed so far. Genetic analysis (MLPA) of most common MODY genes (GCK, HNF1A, HNF4A) but al...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2015
    • •
  • 8 498 tis. Kč
    • •
  • 8 498 tis. Kč
    • •
  • MZ
Project

Mechanisms of the monogenic diabetes onset, progression and therapy (GJ15-03834Y)

the function of mutations in the glucokinase and transcription factors known to cause MODY of the particular proteins responsible for the MODY onset, and will determine changes of the sulfonylurea derivatives already used in the th...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2017
    • •
  • 6 500 tis. Kč
    • •
  • 6 500 tis. Kč
    • •
  • GA ČR
Project

Pancreatic beta cell-related genes and their role in the pathogenesis and treatment of monogenic diabetes (NV18-01-00078)

Up to 5% of the diabetes mellitus is caused by the monogenic defect of the beta cell function. Identification of the genetic background enables to diagnose specific forms of hereditary diabetes (e. g. MODY subtypes or monogenic forms of auto...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2022
    • •
  • 11 275 tis. Kč
    • •
  • 11 275 tis. Kč
    • •
  • MZ
Project

Validation of diagnostic approach in children and adolescents with randomly found hyperglycemia. (NB7420)

In about 100 children and adolescents, the cause of randomly found hyperglycemia will be estimated using metabolic investigation, estimation of autoantibodies and molecular genetic analysis. A diagnostic flowchart for clinical routine will be develop...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2003 - 2005
    • •
  • 2 341 tis. Kč
    • •
  • 2 322 tis. Kč
    • •
  • MZ
Project

Candidate genes and their roles in the pathogenesis of diabetes mellitus type 2 and gestational diabetes (NR7809)

To search for genetic markers of DM2 and gestational diabetes in Czech population using the candidate gene approach that enable us to detect the persons who are predisposed to diabetes and to prevent the disease. This study contributes to the better ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2008
    • •
  • 11 830 tis. Kč
    • •
  • 11 821 tis. Kč
    • •
  • MZ
Project

Whole genome sequencing as tool for search of novel variations causing monogenic diabetes and hyperinsulinism (NW24-01-00160)

Monogenic forms of diabetes (Maturity-Onset Diabetes of the Young, syndromic diabetes, neonatal diabetes) and congenital hyperinsulinism rank among rare diseases. All represent the prime example of successful application of precision medicine. Howeve...

Endocrinology and metabolism (including diabetes, hormones)

  • 2024 - 2027
    • •
  • 11 930 tis. Kč
    • •
  • 11 930 tis. Kč
    • •
  • MZ
Project

Interaction of diphosphoryl derivates of acyclic nucleotide analogs with eucaryotic DNA - polymerases (GA203/96/0284)

We propose to investigate the effect of substitution at the purine ring system upon the response of individual DNA polymerases to base-modi-fied diphosphates of acyclic nuc-leotide analogues. The ulti-mate goal of our project is to gain bett...

CC - Organická chemie

  • 1996 - 1998
    • •
  • 3 020 tis. Kč
    • •
  • 1 866 tis. Kč
    • •
  • GA ČR
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