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642 (0,103s) •

Project

Advanced macromolecular vaccines for the treatment of infectious and neoplastic diseases (LTAUSA18173)

components to the macromolecular carriers with respect to the vaccine immunogenicityAim of this project consists in development of advanced macromolecular vaccines intended for safe and efficient immunization of a host aga...

Organic chemistry

  • 2019 - 2022
    • •
  • 5 880 tis. Kč
    • •
  • 5 880 tis. Kč
    • •
  • MŠMT
Project

Polymeric Two-Component Systems Containing Phthalocyanines and Photochromic Molecules (MEB050815)

The aim of the project is simultaneous theoretical and experimental research into mechanism affecting the charge carrier mobility and concentration in phtalocyanines and other conjugated macromolecular compounds, and exploration of ...

CH - Jaderná a kvantová chemie, fotochemie

  • 2008 - 2009
    • •
  • 71 tis. Kč
    • •
  • 71 tis. Kč
    • •
  • MŠMT
Project

Novel Generation of Polymer Drug Carrier Systems for Site-specific Therapy (IAA4050201)

a synthetic water-soluble polymer carrier which, thanks to his macromolecular character carrier bearing covalently attached drug molecules and targeting tumor-cell-specific cells. The drug can be activated after its releas...

CD - Makromolekulární chemie

  • 2002 - 2006
    • •
  • 11 639 tis. Kč
    • •
  • 4 846 tis. Kč
    • •
  • AV ČR
Project

Polymeric cytostatics (GA305/02/1425)

toxicity greatly diminished if the cytotoxic drug is conjugated to a macromolecular carrier. We have documented the advantages of water-soluble copolymer carrier (PHPMA so far has been based on a non-biodegradable poly (HP...

EC - Imunologie

  • 2002 - 2004
    • •
  • 9 837 tis. Kč
    • •
  • 5 697 tis. Kč
    • •
  • GA ČR
Project

Multifunctional Polymer Systems with Cytostatic and Immunomobilizing Activities (IAAX00500803)

. The new generation of the macromolecular drug delivery systems will be designed protected therapeutically active monoclonal antibody. The structures of macromolecular......

CD - Makromolekulární chemie

  • 2008 - 2012
    • •
  • 12 542 tis. Kč
    • •
  • 12 542 tis. Kč
    • •
  • AV ČR
Project

Macromolecular chemotherapeutics (IBS5020101)

transplantation and for purging of autologous bone-marrow grafts. The polymeric carriers we addition to a proteolytically cleavable bond between the drug and the carrier we will test new conjugates where the bond between the drug a...

CD - Makromolekulární chemie

  • 2001 - 2005
    • •
  • 21 359 tis. Kč
    • •
  • 14 549 tis. Kč
    • •
  • AV ČR
Project

Personalized macromolecular vaccines agains cancer diseases (GA19-08176S)

Active immunization by means of tumor-specific antigens (neoantigens) represents a very promising way of individualized immunotherapy of cancer diseases. Current approaches based on the direct administration of the neoantigens together with the adjuv...

Polymer science

  • 2019 - 2023
    • •
  • 4 613 tis. Kč
    • •
  • 4 589 tis. Kč
    • •
  • GA ČR
Project

New macromolecular systems for targeted delivery of biological active compounds in the living organism (GV307/96/K226)

Based on successful feasibility studies in the past years it is proposed to study new polymeric systems for site-specific delivery of biologically active substances (BAS). These are composed of a water soluble polymeric carrier to which BAS....

CD - Makromolekulární chemie

  • 1996 - 2001
    • •
  • 47 138 tis. Kč
    • •
  • 40 682 tis. Kč
    • •
  • GA ČR
Project

Spherical „horse in vacuum“ or applicable micelles? Behavior and shape of nanoparticles – anticancer drug carriers in real blood environment. (GC15-10527J)

Macromolecular nanoparticles have been considered as one of the most perspective solid tumor-targeted drug carriers. The main aim of the proposal is to investigate the inner structure of nanoparticles composed clinically related pol...

CF - Fyzikální chemie a teoretická chemie

  • 2015 - 2018
    • •
  • 5 751 tis. Kč
    • •
  • 5 751 tis. Kč
    • •
  • GA ČR
Project

Mechanisms and dynamics of macromolecular complexes (EF15_003/0000441)

Project will clarify mechanism and operating of large macromolecular complexes such as complexes of photosynthetic pigments, a role in the replication of RNA viruses and folding and regulation of cellular processes, recombination mechanism i...

EE - Mikrobiologie, virologie

  • 2016 - 2023
    • •
  • 207 410 tis. Kč
    • •
  • 194 945 tis. Kč
    • •
  • MŠMT
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