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Projects

7 788 projects (0,233s) •

Project

The role of neurotransmitters in mechanism of action of non-opioid analgesics (NR9072)

The primary objective is effort for definition of alternative mechanisms of antinociceptive/analgesic actions for non-opioid analgesic drugs (paracetamol and pyrazolones)beyond the inhibition of cyclooxygenases. The major purpose of...

FR - Farmakologie a lékárnická chemie

  • 2006 - 2008
    • •
  • 1 276 tis. Kč
    • •
  • 1 265 tis. Kč
    • •
  • MZ
Project

Analysis of novel generation of photosensitizers mechanism of action and potential use for photodynamic therapy (GA301/01/0976)

The aim of this project is to study mechanism of action of a new generation of photosensitizers (PS) prepared on the basis of oligopyrrolic macrocycles, namely porphyrins and expanded porphyrins, and optimizing conditions for their ...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 2 900 tis. Kč
    • •
  • 1 700 tis. Kč
    • •
  • GA ČR
Project

Cytostatic hetero-fused 7-deazapurine nucleosides, pharmacology, metabolism and mechanism of action. (GA19-08124S)

Recently we discovered that hetero-fused 7-deazapurine nucleosides exert nanomolar cytostatic activity, but their biological target and mechanism of action are unknown. Therefore, we propose to synthesize other analogues and derivat...

Medicinal chemistry

  • 2019 - 2021
    • •
  • 11 465 tis. Kč
    • •
  • 11 123 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanism of melatonin action in gonadotrophs (IAA511408)

9F - 9

  • 1994 - 1996
    • •
  • 206 tis. Kč
    • •
  • 316 tis. Kč
    • •
  • AV ČR
Project

Molecular Mechanism of Melatonin Action in Gonadotropes (GA305/93/0585)

ED - Fyziologie

  • 1993 - 1995
    • •
  • 276 tis. Kč
    • •
  • 552 tis. Kč
    • •
  • GA ČR
Project

Metal ion complexes of nucleic acid constituents with potentials in antiviral and anticancer therapy (OC D20.002)

Development of chemistry of metal ion interactions with nucleobases in biologically active nucleotide analogues, with the aim to ascertain the principles of their participation in the mechanisms of action. Special attention will be ...

CC - Organická chemie

  • 2001 - 2005
    • •
  • 5 026 tis. Kč
    • •
  • 2 564 tis. Kč
    • •
  • MŠMT
Project

Study of molecular and functional mechanism of novel cytostatics (cyclic polymethinum salts) using human genom-wide screening (GA17-07822S)

. The investigation of mechanism of action will be divided into four basic levels 1) Identification of cellular localization; 2) Identification of mechanisms responsible for cytotoxicity and cell death; 3) Identification of...

FR - Farmakologie a lékárnická chemie

  • 2017 - 2019
    • •
  • 9 249 tis. Kč
    • •
  • 8 691 tis. Kč
    • •
  • GA ČR
Project

Molecular Mechanism of Synergetic Action of Environmental Toxic Factors (IA40451)

CE - Biochemie

  • 1992 - 1994
    • •
  • 0 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • AV ČR
Project

Betulinic acid derivatives, identification of mechanism of anticancer action based on expression profiling. (GP301/09/P433)

drugs require active search for compounds with novel mechanisms of antitumour action. Our group is studying the mechanisms by which the triterpenoid compounds exert obtained will be compared to the profiles of drugs with i...

FR - Farmakologie a lékárnická chemie

  • 2009 - 2011
    • •
  • 1 167 tis. Kč
    • •
  • 1 167 tis. Kč
    • •
  • GA ČR
Project

Study on mechanism of antineoplastic action of an anticancer drug ellipticine (GA203/06/0329)

Mechanism of anticancer agent ellipticine action has not yet been precisely explained. It was suggested that the prevalent mechanisms of ellipticine are intercalation into DNA and inhibition of topoisomerase II. Recently, w...

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 190 tis. Kč
    • •
  • 1 190 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 7 788