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14 (0,107s) •

Project

Advanced mass spectrometric strategies for detection of pome fruit disease. (OC09062)

(i) Development and documentation of the potential of two alternative techniques employing time-of-flight mass spectrometry (TOF MS) to enable fast and comprehensive metabolite profiling in pome trees (ed parts and fruits). (ii) Investigation the pos...

CB - Analytická chemie, separace

  • 2009 - 2011
    • •
  • 1 099 tis. Kč
    • •
  • 1 099 tis. Kč
    • •
  • MŠMT
Project

Prediction of gestational diabetes on the basis of steroid metabolism (NV17-30528A)

Gestational diabetes mellitus (GDM) is a frequent complication. We have previously investigated the role of candidate genes and their genetic variability in the pathophysiology of GDM. The obtained data and current knowledge showing an expression of ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2021
    • •
  • 11 201 tis. Kč
    • •
  • 11 154 tis. Kč
    • •
  • MZ
Project

Role of neuroactive steroids in mechnanism of action of clozapine (NU20-04-00389)

In our previous projects, we have demonstrated the role of neurosteroids in schizophrenia in both the animal model and clinical research. Furthermore, we demonstrated the effect of pragnanolone derivatives in the animal model of schizophrenia. A numb...

Psychiatry

  • 2020 - 2023
    • •
  • 18 948 tis. Kč
    • •
  • 18 948 tis. Kč
    • •
  • MZ
Project

New approaches to alkylchloroformate-mediated sample preparation for parallel GC-MS and LC-MS for metabolite analysis in biofluids (GA203/09/2014)

Biofluids in living organisms contain thousands of metabolites of diverse polarity. At present, their complex, metabolomic analysis is far less developed than their transcriptomic and proteomic equivalents. Measurement of most as possible metabolites...

CB - Analytická chemie, separace

  • 2009 - 2011
    • •
  • 2 087 tis. Kč
    • •
  • 2 087 tis. Kč
    • •
  • GA ČR
Project

IdENtIfication of factors influencing adherence to pharmacotherapy in patients with type 2 diabetes using untarGeted MetAbolomics (ENIGMA) (NU20-01-00186)

Patient adherence along with pharmacokinetics are the most significant sources of variability in response to treatment. Thus, adherence monitoring should be an integral part of patient care, especially for chronic diseases such as type 2 diabetes (T2...

Endocrinology and metabolism (including diabetes, hormones)

  • 2020 - 2024
    • •
  • 14 007 tis. Kč
    • •
  • 13 793 tis. Kč
    • •
  • MZ
Project

New biomarkers of inherited metabolic diseases (NU20-08-00367)

Inherited metabolic diseases (IMDs) are the largest subgroup of rare diseases constituting serious health problems. They are typically caused by reduced enzyme activity or protein transporter function resulting in changes in metabolite levels. These ...

Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

  • 2020 - 2023
    • •
  • 9 065 tis. Kč
    • •
  • 9 065 tis. Kč
    • •
  • MZ
Project

Etiology of severely disturbed sulfur amino acid metabolism a basis for targeted diagnosis and personalized treatment in the Czech Republic (NV19-01-00307)

Sulfur amino acids are essential nutrients needed for proteosynthesis and production of compounds that are necessary for methylations and redox reactions. Homocysteine is an intermediate in the intracellular methionine turnover and may serve as a uni...

Human genetics

  • 2019 - 2022
    • •
  • 10 583 tis. Kč
    • •
  • 10 583 tis. Kč
    • •
  • MZ
Project

Pheochromocytoma as a model of chronic activation of the stress axis in the pathogenesis of metabolic disorders (NV16-30345A)

Chronic stress is considered as a risk factor for developing insulin resistance and diabetes mellitus. Pheochromocytoma is a useful model for studying the influence of long-term catecholamines overproduction on cardiometabolic disorders in humans. Ca...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2016 - 2019
    • •
  • 12 909 tis. Kč
    • •
  • 12 909 tis. Kč
    • •
  • MZ
Project

Advanced biotechnological and behavioral approaches in dental caries research and prevention strategies (NV17-30439A)

Dental caries, a chronic multifactorial disease, is a major oral health problem worldwide. Its etiology involves a complex interplay of microbial, genetic, biochemical, social, physical environmental, and health-influencing behavioral factors. The pr...

FF - ORL, oftalmologie, stomatologie

  • 2017 - 2020
    • •
  • 12 342 tis. Kč
    • •
  • 11 699 tis. Kč
    • •
  • MZ
Project

Early diagnostics of hepatocellular carcinoma in patients with liver cirrhosis by novel molecular spectrometric biomarkers in blood plasma (NV19-08-00525)

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver, the development of which is linked to liver cirrhosis. The only way to improve the very poor prognosis of HCC is an early diagnosis. The current surveillance of at-ris...

Analytical chemistry

  • 2019 - 2023
    • •
  • 12 461 tis. Kč
    • •
  • 12 461 tis. Kč
    • •
  • MZ
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