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3 (0,063s)

Project

Mitochondrial adaptor protein Miro1 in heart disease (NW25-02-00459)

using mouse models document that knocking out the GTPase adapter protein Miro1 to increased fibrosis. This model implies inducible Miro1 KO specifically in cardiomyocytes (CMs) This effect is likely CM-specific, as Miro1 i...

Cell biology

  • 2025 - 2028
  • 14 340 tis. Kč
  • 14 340 tis. Kč
  • MZ
Project

Molecular mechanism of mitochondrial movement between cells (GA18-10832S)

Our recent research documents horizontal transfer of mitochondria with their DNA payload between cells. Here, we will study the molecular mechanism of inter-cellular mitochondrial trafficking and its functional consequences. We will use the 'bottom-u...

Cell biology

  • 2018 - 2020
  • 7 691 tis. Kč
  • 7 691 tis. Kč
  • GA ČR
Project

Horizontal transfer of mitochondria in cancer biology (GX21-04607X)

Mitochondria move from donor cells (mesenchymal stem cells, MSCs) to cancer cells with dysfunctional mitochondrial DNA (mtDNA) via tunnelling nanotubes (TNTs) with major role of the adaptor protein Miro1. Recruitment of MSCs to the site of p...

Cell biology

  • 2021 - 2025
  • 49 755 tis. Kč
  • 49 755 tis. Kč
  • GA ČR
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