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2 590 (0,165s) •

Project

Multidrug-resistant tuberculosis in the Czech republic. Microbiological, epidemiological and genotype features. (NI5905)

An evaluation of microbiological, epidemiological and genotype features of multidrug-resistant tuberculosis in the Czech Republic including a proposal for treatment of diseases caused by multidrug-resistant strains...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2000 - 2002
    • •
  • 5 405 tis. Kč
    • •
  • 1 452 tis. Kč
    • •
  • MZ
Project

Multidrug Resistance in Cancer Molecular, Celular and Clinical Aspects. (IZ4132)

The objective of the study is to elucidate the molecular,cellular and clinical aspects of multidrug resistance in cancer.We intend to evaluate the prognostic value of multidrug resistance in haematological and soli...

FD - Onkologie a hematologie

  • 1997 - 2001
    • •
  • 13 372 tis. Kč
    • •
  • 13 079 tis. Kč
    • •
  • MZ
Project

Genetic basis of multidrug resistance in major clonal lineages of Acinetobacter baumannii (GA310/08/1747)

on the genetic factors responsible for multidrug resistance (MDR) or panresistance of the multidrug resistance of two major European MDR clonal lineages (Clones I and II systems in the evolution of multidrug

EE - Mikrobiologie, virologie

  • 2008 - 2010
    • •
  • 2 811 tis. Kč
    • •
  • 2 811 tis. Kč
    • •
  • GA ČR
Project

Identification of new diagnostic/predictive biomarkers and compounds applicable to personalized treatments of multidrug resistant tumors (LTC19020)

The aim of this project is identification and validation of new prognostic and predictive molecular biomarkers of multidrug resistence in solid tumors. New molecular biomarkers will be characterized in detail by analysis of genetic...

Human genetics

  • 2019 - 2022
    • •
  • 3 936 tis. Kč
    • •
  • 3 936 tis. Kč
    • •
  • MŠMT
Project

Overcoming P-glycoprotein-mediated multidrug resistance (MDR) (GA310/99/P020)

One of the most frequent forms of acquired resistance is so called multidrug resistance caused by overexpression of P-glycoprotein (Pgp). Pgp functions as an ATP excretion from the cell. Several possibilities exist to overc...

EC - Imunologie

  • 1999 - 2001
    • •
  • 792 tis. Kč
    • •
  • 719 tis. Kč
    • •
  • GA ČR
Project

Design and enzyme targeting of antibacterial active compounds against multidrug resistant strains (NT13346)

This is an interdisciplinary applied research, aimed at suppressing extensively growing mycobacterial infections, including resistant and multidrug resistant strains. The project is based on a molecular modelling (in silico...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2015
    • •
  • 8 054 tis. Kč
    • •
  • 8 054 tis. Kč
    • •
  • MZ
Project

Reversal of antibiotic resistance by inhibition of trans-membrane transport. (OC B16.001)

The main objective of the action is to investigate mechanisms of multidrug resistance in cancer, bacterial, parasitic and fungal infections with a view to develop new drugs capable of reversing this drug resistance. In the ...

CB - Analytická chemie, separace

  • 2001 - 2005
    • •
  • 2 102 tis. Kč
    • •
  • 1 864 tis. Kč
    • •
  • MŠMT
Project

Resistance of Salmonella to antimicrobial compounds (1B44019)

Increase in incidence of multidrug resistant Salmonella spp. has been observed of the collection of the multidrug resistant isolates of Salmonella spp. (incl frequently responsible for drug resistance in S...

EE - Mikrobiologie, virologie

  • 2004 - 2008
    • •
  • 8 149 tis. Kč
    • •
  • 8 149 tis. Kč
    • •
  • MZe
Project

Study of cell cycle alterations and their significance for tumor cell resistance to anti-cancer drugs (GP301/03/P096)

Resistance of human tumors to a wide range of potent chemotherapeutic agents, designated multidrug resistance, remains a major obstacle to the successful therapy of human cancer. Intensive research in this field has defined...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 514 tis. Kč
    • •
  • 244 tis. Kč
    • •
  • GA ČR
Project

Evolution of emergent multidrug resistant Streptococcus pneumoniae 19A serotype in era of pneumococcal vaccination. (NV16-27109A)

Pneumococcus is the major cause of pneumonia, meningitis and bacteremia. A major concern is the occurence of multidrug-resistant (MDR) pneumococci. As the pneumococcal conjugate vaccines target most of MDR serotypes, it was postulat...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2016 - 2019
    • •
  • 8 566 tis. Kč
    • •
  • 8 071 tis. Kč
    • •
  • MZ
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