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Principal signaling pathways regulating NG2 glia proliferation and differentiation following brain injuries (GA17-04034S)
In the adult brain NG2-glia represent an important cell type in relation an important role in proliferation and cell-fate decision of NG2-glia. The main objective of this study is to define the role of the Shh and ...
FH - Neurologie, neurochirurgie, neurovědy
- 2017 - 2019 •
- 12 507 tis. Kč •
- 11 937 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2019
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Grantová agentura České republiky
Gene expression profiling and functional characterization of glial cell subpopulations following ischemic brain injury (GA13-02154S)
Astrocytes and NG2-glia subpopulations display striking physiological high throughput platform will be employed to classify astrocytic and NG2-glia and following cerebral ischemia using transgenic mice in which dif...
EB - Genetika a molekulární biologie
- 2013 - 2016 •
- 10 720 tis. Kč •
- 10 720 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Cell volume regulation in glial cells during brain ischemia/reperfusion (GAP303/10/1338)
The aim of this study is to identify the major ion channels or transporters participating in astrocyte and NG2 glia swelling and volume regulation during ischemia of astrocyte and NG2 glia responses to ischemic ins...
FH - Neurologie, neurochirurgie, neurovědy
- 2010 - 2012 •
- 3 996 tis. Kč •
- 3 996 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2010 - 31. 12. 2012
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Impact of Wnt signaling modulation on the heterogeneity and functions of NG2-expressing cells in the adult cortex following focal brain ischemia (GA24-10912S)
in the affected area of the brain. Cells expressing proteoglycan NG2, i.e., perivascular cells and NG2 glia, contribute to alleviating the effects of the stroke on the nervous tissue. The Wnt signaling pathway is active in...
Neurosciences (including psychophysiology)
- 2024 - 2026 •
- 11 883 tis. Kč •
- 11 883 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2024 - 31. 12. 2026
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Glial cells- the key players in the progression of amyotrophic lateral sclerosis (GA19-02046S)
A striking functional heterogeneity exists within astrocytes, NG2-glia, oligodendrocytes and microglia. It is presented in various subpopulations transgenic mice carrying superoxide dismutase mutation and fluorescently labeled g...
Neurosciences (including psychophysiology)
- 2019 - 2023 •
- 9 950 tis. Kč •
- 9 734 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2019 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Grantová agentura České republiky
Disturbed regulation of mTOR signaling in glial cells following cerebral ischemia (GA23-06269S)
and NG2 glia in the penumbra and ischemic core using RNA-seq and metabolomics processes regulated by mTORC1/2 in glia following focal cerebral ischemia. First, we......
Neurosciences (including psychophysiology)
- 2023 - 2025 •
- 9 885 tis. Kč •
- 9 885 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2023 - 31. 12. 2025
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Induction of neuro- and gliogenesis in rat brain after ischemia - the role of morphogenes and growth factors in the nervous tissue regeneration. (GA305/09/0717)
. In addition to endogenous neural stem cells, also astrocytes and NG2-glia play as the proliferation and migration of astrocytes and NG2-glia. This study should also contribute......
ED - Fyziologie
- 2009 - 2011 •
- 3 381 tis. Kč •
- 3 381 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The Role of TRPV4 Channels in the Development of Cytotoxic Edema and Formation of Glial Scar Following Ischemic Brain Injury (GJ18-06446Y)
with cell-specific Cre-reporter mice, we also aim to study the differentiation of NG2 glia into oligodendrocytes after ischemia, and cell death/proliferation induced......
Neurosciences (including psychophysiology)
- 2018 - 2018 •
- 602 tis. Kč •
- 602 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2018 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Involvement of Wnt/β-catenin signaling in neurogenesis and gliogenesis following brain ischemic injury - analysis at the single cell level (GA21-24674S)
of glial cells, i.e. NG2 glia and GFAP-positive astrocytes, which significantly...
Neurosciences (including psychophysiology)
- 2021 - 2023 •
- 12 173 tis. Kč •
- 12 173 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2021 - 31. 12. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
The role of glial TRPV4 channels in brain edema formation and post-ischemic regeneration (GA20-05770S)
cellular contributors to edema formation, the impact of TRPV4 deletion on glia...
Neurosciences (including psychophysiology)
- 2020 - 2023 •
- 10 671 tis. Kč •
- 10 671 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2020 - 30. 6. 2023
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
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