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262 (0,184s)

Project

Genetics of adult-onset familial focal segmental glomerulosclerosis (FSGS) – implications for individualized therapy and successful kidney transplantation (NV19-06-00443)

transplantation. New Generation Sequencing (NGS) detects mutations in a large number of genes examination and NGS in patients and their relatives with genetic FSGS, 2) identification......

Human genetics

  • 2019 - 2023
  • 13 856 tis. Kč
  • 12 179 tis. Kč
  • MZ
Project

The development and standardization of method for analysis of antigen receptor gene rearrangements using next generation sequencing for use in immunoh (NV16-32568A)

Next generation sequencing (NGS) has opened a unique possibility to sequence on the usefulness of NGS Ig/TR detection for the assessment of minimal residual disease (MRD in international collaboration several types of NGS I...

EC - Imunologie

  • 2016 - 2019
  • 9 663 tis. Kč
  • 9 663 tis. Kč
  • MZ
Project

Next generation sequencing for early diagnosis and individualized therapy of hypertrophic cardiomyopathy (NV15-34904A)

. Next Generation Sequencing (NGS) detects mutations in large number of genes or even clinical examination (phenotyping) and NGS in patients and their relatives......

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2015 - 2018
  • 11 717 tis. Kč
  • 11 717 tis. Kč
  • MZ
Project

Modern approach to the field of primary immunodeficiencies translating precise molecular and functional diagnosis to therapy (NV18-05-00162)

-generation sequencing (NGS) methods. However, the impact of newly identified genetic...

Immunology

  • 2018 - 2021
  • 9 919 tis. Kč
  • 9 919 tis. Kč
  • MZ
Project

Comprehensive prognostic and predictive panel for chronic lymphocytic leukemia a next-generation sequencing tool suitable for clinical practice and study of genetic architecture behind the disease evolution (NV19-03-00091)

. For this purpose, a highly complex next-generation sequencing (NGS) tool simultaneously benefits of capture-based NGS technology enabling parallel analysis of IGHV mutational clonality. We presume that our NGS panel tailo...

Oncology

  • 2019 - 2022
  • 14 426 tis. Kč
  • 14 426 tis. Kč
  • MZ
Project

Etiology of severely disturbed sulfur amino acid metabolism a basis for targeted diagnosis and personalized treatment in the Czech Republic (NV19-01-00307)

Sulfur amino acids are essential nutrients needed for proteosynthesis and production of compounds that are necessary for methylations and redox reactions. Homocysteine is an intermediate in the intracellular methionine turnover and may serve as a uni...

Human genetics

  • 2019 - 2022
  • 10 583 tis. Kč
  • 10 583 tis. Kč
  • MZ
Project

The human gut virome, viruses in blood and the development of islet autoimmunity in two Nordic birth cohorts at a high risk of type 1 diabetes (NV15-29078A)

-generation sequencing (NGS) followed by confirmation with specific PCR tests from stool two controls matched to each case. The virome will be characterized by NGS from......

EE - Mikrobiologie, virologie

  • 2015 - 2018
  • 9 408 tis. Kč
  • 9 408 tis. Kč
  • MZ
Project

Elucidating the etiopathogenesis of a growth disorder in children with clinically diagnosed growth hormone deficiency using modern genetic methods as a way to optimize the diagnostics and the treatment (NU22J-07-00014)

sequencing (NGS) recently improved substantially the knowledge about short stature pathogenesis. Using NGS, it is possible to discover the cause of growth disorder hormone deficiency by NGS methods, and subsequently to opt...

Paediatrics

  • 2022 - 2025
  • 6 888 tis. Kč
  • 6 888 tis. Kč
  • MZ
Project

Genomic study of a climate-driven population replacement (LH15255)

The principal aim is to test the hypothesis that a climate-driven population replacement similar to that in Britain occurred also in other parts of Europe, specifically during the colonization of Scandinavia. Using cutting-edge methods of population ...

EG - Zoologie

  • 2016 - 2017
  • 1 942 tis. Kč
  • 1 942 tis. Kč
  • MŠMT
Project

Improved Interpretation of Next Generation Sequencing Datasets in Patients with Inherited Cardiomyopathy Using Functional Models Based on Induced Pluripotent Stem Cells and Advanced Cardiac Imaging in Families (NV19-08-00122)

of next-generation sequencing (NGS) techniques. However, NGS often identifies large interpretation of the NGS datasets generated in studied CMP families and thus facilitate......

Cell biology

  • 2019 - 2023
  • 15 852 tis. Kč
  • 15 852 tis. Kč
  • MZ
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