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Projects

28 projects (0,121s) •

Project

The mitochondrial genome and oxidative phosphorylation system in metabolic syndrome (OC08017)

Mitochondrial oxidative phosphorylation (OXPHOS) provides most of energy in mammalian cells and tissues. OXPHOS system is uniquely encoded by both nuclear and mitochondrial genes. Dysfunction of OXPHOS are known to cause nu...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 1 706 tis. Kč
    • •
  • 1 706 tis. Kč
    • •
  • MŠMT
Project

MitoChip microarray for mitochindrial gene expression analysis and its application for study of nuclear defects of oxidative phosphorylation (NR8069)

Deficiencies of oxidative phosphorylation (OXPHOS) form important group of the OXPHOS deficiencies results from mutation of nuclear encoded mitochondrial genes to contribute significantly to differential diagnosis and research of nu...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 6 198 tis. Kč
    • •
  • 6 060 tis. Kč
    • •
  • MZ
Project

The role of cytochrome c oxidase subunit COX6B isoforms in regulation of mitochondrial function in health and disease (GA22-21082S)

phosphorylation (OXPHOS) system responsible for ATP production in mammalian cells. Expression of tissue-specific isoforms of COX subunits represents a crucial mechanism of OXPHOS phenomenon of COX6B isoform exchange and its effect ...

Cell biology

  • 2022 - 2025
    • •
  • 7 050 tis. Kč
    • •
  • 7 050 tis. Kč
    • •
  • GA ČR
Project

Supramolecular assemblies in structural organization of inner mitochondrial membrane (GPP303/10/P227)

Recently, our understanding of oxidative phosphorylation (OXPHOS) complexes sufficient evidence for existence of OXPHOS supercomplexes in mammals, the mechanism project is to determine factors involved in association of mammalian

ED - Fyziologie

  • 2010 - 2014
    • •
  • 2 015 tis. Kč
    • •
  • 2 015 tis. Kč
    • •
  • GA ČR
Project

Targeting mitochondrial metabolism in pancreatic cancer therapy (GJ20-11724Y)

link between downregulated mitochondrial oxidative phosphorylation (OXPHOS in OXPHOS remodelling and metastatic potential. We will describe how SMAD4 loss affects to mitochondrial drugs. Overall, the project will assess the role of...

Cell biology

  • 2020 - 2022
    • •
  • 6 300 tis. Kč
    • •
  • 6 300 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial energetic metabolism in neonatal period (NT11186)

and amount of OXPHOS and PDH complexes in buccal swab cells and dry blood spots will be developed. The methods will be used for the analysis of biogenesis of OXPHOS and PDH......

FG - Pediatrie

  • 2010 - 2014
    • •
  • 9 836 tis. Kč
    • •
  • 9 836 tis. Kč
    • •
  • MZ
Project

Mitochondrial disorders with instability of mitochondrial DNA (NV17-30965A)

Mitochondrial disorders (MD) with estimated incidence 1:4000 are caused by disturbances of oxidative phosphorylation system (OXPHOS) and represent genetically and clinically heterogeneous group of diseases with significant impact on morbidit...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 13 003 tis. Kč
    • •
  • 12 960 tis. Kč
    • •
  • MZ
Project

Genetic bases of combined deficiency of oxidative phosphorylation complexes (NT13114)

Mitochondrial diseases caused by deficiency of one or several OXPHOS complexes represent a heterogeneous group of severe metabolic disorders caused by mutation in mtDNA or >100 nuclear genes. In group of 57 patients with combined OXPHOS<...

FG - Pediatrie

  • 2012 - 2015
    • •
  • 9 698 tis. Kč
    • •
  • 9 650 tis. Kč
    • •
  • MZ
Project

Molecular biology of fatty acid (amphiphilic) anion binding site of mitochondrial phosphate carrier (ME 085)

Fatty acids(FA) are recently recognized to be key physiological regulators of oxidative phosphorylation (OxPho), causing partial uncoupling while being translocated resetting efficiency of OxPho. The process is undoubtedly important...

CE - Biochemie

  • 1997 - 1999
    • •
  • 750 tis. Kč
    • •
  • 350 tis. Kč
    • •
  • MŠMT
Project

SUCLG2 as a new tumour suppressor affecting mitochondrial metabolism Molecular mechanism and clinical relevance (GA22-07091S)

(OXPHOS). We propose that mutations in the SUCLG2 subunit of SUCL we have recently function, including the TCA cycle and OXPHOS. We will study the impact of SUCLG2 mutations on the TCA cycle and OXPHOS, both affected by CI...

Oncology

  • 2022 - 2024
    • •
  • 11 148 tis. Kč
    • •
  • 11 136 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 28