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9 (0,068s) •

Project

Novel reactive groups introduced in nucleic acids for modification with oxoosmium complexes structural and analytical aspects (GA15-08434S)

with osmium tetroxide (reacting with unsaturated C-C bonds) or potassium osmate (reacting with the osmium reagents will be studied with respect to the type of introduced reactive group properties of the NA-osmium adducts w...

CB - Analytická chemie, separace

  • 2015 - 2019
    • •
  • 7 935 tis. Kč
    • •
  • 7 935 tis. Kč
    • •
  • GA ČR
Project

Reaction of Six-valent and Eight-valent Osmium Complexes with Biomacromolecules and Their Application in Biomedicine (GPP301/10/P548)

We propose to explore modifications of biomacromolecules, containing 1,2-diol groups, with six-valent osmium nitrogenous ligand complexes [Os(VI)L]. The adducts will be analyzed with electrochemical, spectroscopic, immunochemical or other su...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 305 tis. Kč
    • •
  • 1 305 tis. Kč
    • •
  • GA ČR
Project

Local DNA structures ,their chemical reactivity and relations to genetic diseases and cancer (GA204/96/1680)

This laboratory proposed earlier single-strand selective chemical probes of the DNA structure based on osmium tetroxide complexes with nitrogen ligand (Os,L) which are now widely used. In this project we propose a research which will result ...

CE - Biochemie

  • 1996 - 1998
    • •
  • 3 707 tis. Kč
    • •
  • 2 871 tis. Kč
    • •
  • GA ČR
Project

Strong electron correlations in systems with spin-orbit coupling (GA13-25251S)

such as strontium iridates, Na4Ir3O8, and osmium compounds. The physical characteristics...

BM - Fyzika pevných látek a magnetismus

  • 2013 - 2015
    • •
  • 2 145 tis. Kč
    • •
  • 2 145 tis. Kč
    • •
  • GA ČR
Project

Advanced techniques for biological samples imaging using X-ray computed nanotomography (TJ01000382)

Objective of this project is to increase quality of nanotomographic measurement of biological samples and degradable materials with the use of Nano3DX to enable higher applicabillity of acquired data. During the project parametres of measument in pha...

Electrical and electronic engineering

  • 2018 - 2019
    • •
  • 1 967 tis. Kč
    • •
  • 1 666 tis. Kč
    • •
  • TA ČR
Project

Applications of chemical structural probes and electroanalytical methods in DNA damage detection. Development of DNA sensors. (KJB4004302)

diseases such as cancer. We propose to use osmium tetroxide complexes (Os,L...

CG - Elektrochemie

  • 2003 - 2005
    • •
  • 2 052 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • AV ČR
Project

Metallodrugs based on osmium, platinum and ruthenium complexes. From mechanistic studies to novel, more efficient chemotherapy of cancer (GAP301/10/0598)

The main objective is to increase knowledge and understanding of the design and mechanisms of action of antitumor metallodrugs, and to use this enhanced knowledge in combination with modern genomic research to develop new classes of metallodrugs with...

FD - Onkologie a hematologie

  • 2010 - 2014
    • •
  • 4 950 tis. Kč
    • •
  • 4 950 tis. Kč
    • •
  • GA ČR
Project

Bimodal coordination compounds of non-platinum transition metals as a new type of anticancer active substances (GJ17-08512Y)

A project deals with synthesis, characterization and antitumor activity studies of the innovative bimodal complexes of non-platinum transition metals (Ru, Os, Ir), which involve an antitumor active organic ligand in their structures, and which transf...

CA - Anorganická chemie

  • 2017 - 2019
    • •
  • 3 128 tis. Kč
    • •
  • 3 128 tis. Kč
    • •
  • GA ČR
Project

The system Os-Mo-S and its geological application (GA205/05/0459)

An outstanding issue in Re-Os geochronology is the potential decoupling of daughter 187 Os and parent 187 Re after the crystallization of molybdenite. The most important factors that can be expected to have an influence on the Re-Os decoupling is the...

DB - Geologie a mineralogie

  • 2005 - 2007
    • •
  • 1 302 tis. Kč
    • •
  • 1 302 tis. Kč
    • •
  • GA ČR
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