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3 711 (0,078s) •

Project

Influence of P-glycoprotein induction on pharmacokinetics (GP305/01/D089)

P-glycoprotein (P-gp) is a membrane ATP-dependent transporter that is able, because P-gp is not only the cause of multidrug resistance (MDR) of tumor cells to anticancer drugs, but P-gp i...

FR - Farmakologie a lékárnická chemie

  • 2001 - 2004
    • •
  • 1 319 tis. Kč
    • •
  • 696 tis. Kč
    • •
  • GA ČR
Project

P-glycoprotein and its possible contribution to development of resistance to Imatinib in Bcr-Abl expressing cells (NR9482)

Study of the P-gp contribution to the development of resistance to imatinib in Bcr-Abl positive cells using the direct determination of intracellular content of the drug.......

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 3 184 tis. Kč
    • •
  • 3 116 tis. Kč
    • •
  • MZ
Project

Rare and uncommon flavonolignans Chemo-enzymatic preparation and pharmacological activity (GA18-00150S)

signalization, and their inhibitory activities towards multi-drug resistance (MDR) proteins...

Biochemical research methods

  • 2018 - 2020
    • •
  • 7 591 tis. Kč
    • •
  • 6 859 tis. Kč
    • •
  • GA ČR
Project

Complex analysis of role of MDR1 gene in breast tumor resistance (GP305/07/P347)

Multidrug  resistance (MDR) of tumor cells to cytotoxic drugs is one of the major impediments in successful cancer therapy. Increased expression of P-glycoprotein (P-gp), encoded by MDR1 gene, in tumor cells is one of the m...

CE - Biochemie

  • 2007 - 2009
    • •
  • 1 471 tis. Kč
    • •
  • 1 471 tis. Kč
    • •
  • GA ČR
Project

Mapping the surface epitopes of the gp135 glycoprotein of the Maedi- Visna virus (GA524/97/0312)

gp 135 (SU) of the Maedi-Visna virus in terms of the presence of conserved and variable regions, and possibly it's spatial arrangement. We plan to express gp 135 as several bacterial fusion proteins. Each protein ...

EE - Mikrobiologie, virologie

  • 1997 - 1999
    • •
  • 1 906 tis. Kč
    • •
  • 1 706 tis. Kč
    • •
  • GA ČR
Project

Novel methylation of Hexim1 and cyclin composition of positive trancription elongation factor b (P-TEFb) regulate kinase activity of cdk9 (ME09047)

posttranslational modification of proteins, methylation of glutamic acid (E), found in the P-TEFb binding domain of Hexim1, directs association of P-TEFb with 7SK RNP and thus in the regulation of association of P...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 3 247 tis. Kč
    • •
  • 2 224 tis. Kč
    • •
  • MŠMT
Project

Interference of probiotics with factors determining pharmacokinetics of drugs (GA305/08/0535)

at least the intestinal efflux systems such as multidrug resistence-associated protein P-gp, and downregulates activity of cytochromes P450 and other enzymes......

FR - Farmakologie a lékárnická chemie

  • 2008 - 2011
    • •
  • 8 790 tis. Kč
    • •
  • 8 630 tis. Kč
    • •
  • GA ČR
Project

The role of mammalian mitochondrial glycerophosphate dehydrogenase in production of reactive oxygen species (GA303/03/0799)

function of mGPDH which is glycerophosphate (GP)-dependent ROS production.Theaim of this project is: (1) To characterize the molecular mechanism of GP-dependent ROS produc homeostasis and also establish to which extent GP-...

CE - Biochemie

  • 2003 - 2005
    • •
  • 2 161 tis. Kč
    • •
  • 2 161 tis. Kč
    • •
  • GA ČR
Project

Cytosolic and membrane-bound forms of trimeric GTP-binding proteins in desensitization of beta-adrenergic stimulus (GA305/96/0678)

of GTP-binding proteins in desensitization of beta-adrenergic stimulation of brown., Svoboda P., Jasper J.R. and Insel P.A., Proc.Nat.Acad.Sci.USA 86, 7900-7903, 1989; Svoboda P. Kvapil R., Insel P.A. and Ransnas L., Eur. ...

CE - Biochemie

  • 1996 - 1998
    • •
  • 1 285 tis. Kč
    • •
  • 1 285 tis. Kč
    • •
  • GA ČR
Project

NEAR REAL-TIME ANALYSIS OF PERMANENT GPS NETWORK FOR METEOROLOGICAL APPLICATIONS (OC 716.001)

The application of the GPS for the meteorology and the climatology. Both methods consist in monitoring of the total water vapor content in profiles above analysed ground GPS sites, operating in permanent schedule.The results from

DG - Vědy o atmosféře, meteorologie

  • 2001 - 2004
    • •
  • 4 782 tis. Kč
    • •
  • 1 165 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 3 711