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79 (0,161s) •

Project

Characterisation of cytochroems P450 in experimental minipigs (OC 119)

charakterization of (mini)pig cytochrome P450 system and comparison of important characteristics to those of P450 system in man...

GI - Šlechtění a plemenářství hospodářských zvířat

  • 2006 - 2009
    • •
  • 3 415 tis. Kč
    • •
  • 1 600 tis. Kč
    • •
  • MŠMT
Project

Cytochrome P450 active sites (OC 133)

study of compresibility and flexibility of active sites of P450 cytocromes, forms CYP2C9 and CYP3A4...

CE - Biochemie

  • 2006 - 2007
    • •
  • 1 180 tis. Kč
    • •
  • 800 tis. Kč
    • •
  • MŠMT
Project

Role of cytochrome P450 in biodegradation of dyes and triazines by white rot fungi (1P05ME827)

mechanism of degradation of xenobiotics focused on systems containing p450 cytochrom, used by white rot fungi...

EE - Mikrobiologie, virologie

  • 2005 - 2005
    • •
  • 205 tis. Kč
    • •
  • 87 tis. Kč
    • •
  • MŠMT
Project

Role of Cytochromes P450 in the Effects of Cytostatics in Patients and Medical Personnel. (IZ1850)

Cytochromes P450 activate many carcinogens and anticancer to effective metabolites. Genetic and environmental factors influence P 450 activuty. The proposal studies relation of P450 activity to the effects of anticancer drugs in pat...

FM - Hygiena

  • 1995 - 1999
    • •
  • 4 852 tis. Kč
    • •
  • 3 817 tis. Kč
    • •
  • MZ
Project

Modeling drug-drug interactions in vivo using in vitro methods (OC B15.30)

Identification of human cytochrome P450 isozymes involved in the metabolism of memantine and amiodarone. Quantification of inhibitory action of memantine towards human cytochorome P450 isozymes.......

FR - Farmakologie a lékárnická chemie

  • 2000 - 2003
    • •
  • 4 512 tis. Kč
    • •
  • 2 975 tis. Kč
    • •
  • MŠMT
Project

Prediction of metabolic drug-drug interactions based on in-vitro experiments (1P04OCB15.30)

Identification of human cytochrome P450 isozymes involved in the metabolism of memantine and amiodarone. Quantification of inhibitory action of memantine towards human cytochorome P450 isozymes.......

FR - Farmakologie a lékárnická chemie

  • 2004 - 2004
    • •
  • 700 tis. Kč
    • •
  • 700 tis. Kč
    • •
  • MŠMT
Project

Expression of Human Cytochrome P450 2A6 in Bacteria (IZ3505)

FM - Hygiena

  • 1996 - 1998
    • •
  • 2 097 tis. Kč
    • •
  • 2 097 tis. Kč
    • •
  • MZ
Project

Expression of cytochromes P450 in hematopoietic stem cells. (NL7295)

Expression of cytochromes P450 in hematopoietic stem cells obtained by separetion from petipheral blood will be follewed by Northern blogging, real-time PCR, Western blotting and by determination of specific enzyme activities.......

FR - Farmakologie a lékárnická chemie

  • 2002 - 2004
    • •
  • 1 528 tis. Kč
    • •
  • 1 212 tis. Kč
    • •
  • MZ
Project

Pig enzymes of biotransformation (1P05OC050)

recognition of proteins, enzymes contributing to transformations (biotransformations) of substances - cytochromes P450 and other enzymes of transformation of foreign substances......

EB - Genetika a molekulární biologie

  • 2005 - 2008
    • •
  • 2 138 tis. Kč
    • •
  • 1 443 tis. Kč
    • •
  • MŠMT
Project

Pharmacological blockade of cytochrome P450 pathway as a new approach in hypertension treatment (NT11230)

The role of epoxyeicotrienoic acids in the pathophysiology of ANG II-dependent form of hypertension will be studied....

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2010 - 2013
    • •
  • 5 724 tis. Kč
    • •
  • 5 724 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 79