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14 (0,071s) •

Project

Novel readouts for the planar cell polarity (PCP) pathway (GA17-16680S)

pathways regulating polarity is the non-canonical Wnt/planar cell polarity (PCP. Importantly, the molecular basis of PCP signaling in mammalian cells is still almost unknown. This is mainly due to the fact that the whole field of <...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 7 020 tis. Kč
    • •
  • 6 801 tis. Kč
    • •
  • GA ČR
Project

Development of software for archival description based on fundamentals of archival processing with PCP method (TB0200MV026/MT06)

The process evaluation of current work procedure for the design of a process optimization for the considered software....

AF - Dokumentace, knihovnictví, práce s informacemi

  • 2015 - 2015
    • •
  • 471 tis. Kč
    • •
  • 471 tis. Kč
    • •
  • TA ČR
Project

Revealing the Mechanism of Neural Tube Formation (GA22-06405S)

of the apical cell surface. NT formation has been shown to involve planar cell polarity (PCP). PCP is a universal property of cells polarized in the plane of tissue, which is manifested by the oriented localization of ‘core’ PC...

Developmental biology

  • 2022 - 2024
    • •
  • 6 444 tis. Kč
    • •
  • 6 444 tis. Kč
    • •
  • GA ČR
Project

Structural insights into the function of the key planar cell polarity regulator Vangl2 (GA25-17258S)

The Wnt/planar cell polarity (PCP) pathway is a non-canonical Wnt signaling branch, known for controlling the polarization and migration of cells. Wnt/PCP protein Vangl2. Vangl2 is absolutely essential for PCP establishment...

Biochemistry and molecular biology

  • 2025 - 2027
    • •
  • 13 424 tis. Kč
    • •
  • 13 424 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of non-canonical Wnt signaling in leukemia (GAP301/11/0747)

of non-canonical Wnt signalling (Wnt/PCP pathway) in context of B-Cell Chronic LymphocyticLeukaemia (CLL). Functional studies of the Wnt/PCP pathway in disease conditions by studying the role of the Wnt/PCP signaling pathw...

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 360 tis. Kč
    • •
  • 5 360 tis. Kč
    • •
  • GA ČR
Project

Structural biology of the Wnt/PCP signaling pathway (LUAUS25170)

The non-canonical Wnt pathway, specifically the planar cell polarity (PCP, tissue homeostasis, and cell migration. The PCP pathway controls cell polarity involved in the PCP pathway remains unknown. Within the framework of...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 11 980 tis. Kč
    • •
  • 11 980 tis. Kč
    • •
  • MŠMT
Project

Implementation of the PCP principle into IS BETA (TB05TACR001)

Acquiring new knowledge, skills, services, information and management products and procedures that will be designed for the state administration. The project addresses the specific objective of other providers: • improvement of functioning and upgrad...

IN - Informatika

  • 2016 - 2016
    • •
  • 1 980 tis. Kč
    • •
  • 1 980 tis. Kč
    • •
  • TA ČR
Project

Touching the untouchable; biochemistry of full-length Vangl2 protein (8J25FR012)

The main gap we have identified in the WNT/PCP field is on mechanistic regulators of the WNT/PCP signaling assemble. By applying state-of-the-art structural and PCP establishment mechanisms. The main objectives in this dire...

Biochemistry and molecular biology

  • 2025 - 2026
    • •
  • 200 tis. Kč
    • •
  • 200 tis. Kč
    • •
  • MŠMT
Project

Analysis of WNT/PCP pathway for better management of chronic lymphocytic leukemia (NV15-29793A)

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults in the Czech Republic. The recent data from our laboratories suggest that one of the crucial molecular pathways associated with pathogenesis of CLL is Wnt/PCP signal...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 937 tis. Kč
    • •
  • 9 937 tis. Kč
    • •
  • MZ
Project

Regulation of Transcription of Genes Colding for Light-harvesting Proteins in Phytoplankton under Fluctuating Light Conditions (KJB600200515)

secondary pigments (LHC for chla/b,FCP for chla/c and fucoxanthin, PCP for chl) regulation of LHC, FCP a PCP complexes, c) regulation of particular homologous proteins......

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 790 tis. Kč
    • •
  • 1 790 tis. Kč
    • •
  • AV ČR
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