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925 (0,139s) •

Project

Humanized patient-derived murine xenografts for experimental therapy of hematologic malignancies and for the study of in vivo acquired drug-resistance (NV19-08-00144)

Republic. Patient-derived murine xenografts (PDXs) derived by injection of primary on sufficient numbers of biologically-relevant PDXs might in near future replace most of the proof-of-concept phase 2 studies. We plan to use the de...

Hematology

  • 2019 - 2022
    • •
  • 16 966 tis. Kč
    • •
  • 16 966 tis. Kč
    • •
  • MZ
Project

Single-cell transcriptomics for the analysis of subclonal heterogeneity and clonal evolution of mantle cell lymphoma (GA23-05377S)

lines and patient-derived xenografts (PDX) represent important tools in preclinical established lymphoma cell lines and PDXs derived from one patient. New insights on subclonal heterogeneity and relevance of lymphoma cell lines and...

Hematology

  • 2023 - 2025
    • •
  • 15 740 tis. Kč
    • •
  • 15 716 tis. Kč
    • •
  • GA ČR
Project

Discovery and development of novel tumor-suppressor-based reactivation cancer therapies (NW25-03-00073)

preclinical studies and validations in human tumor explant assays and in CDX and PDX mouse...

Oncology

  • 2025 - 2028
    • •
  • 19 501 tis. Kč
    • •
  • 18 255 tis. Kč
    • •
  • MZ
Project

The impact of cytidine metabolic pathways on cytarabine therapy of hematological malignancies and new diagnostic tools for their analysis (NU22-08-00148)

Cytidine deaminase (CDA) and deoxycytidine monophosphate deaminase (DCTD), deoxycytidine kinase (dCK), 5'-nucleotidase and human equilibrative nucleoside transporter (hENT1) participate in the regulation of cellular nucleotide and nucleoside pools an...

Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

  • 2022 - 2025
    • •
  • 10 318 tis. Kč
    • •
  • 10 318 tis. Kč
    • •
  • MZ
Project

Upgrade of the Czech Centre for Phenogenomics developing towards translation research (EF16_013/0001789)

on the aging process genes involved in this process) and oncology (patient xenografts, PDX unit PDX models - New statistical methods, visualization techniques, and dynamic web interface for PDX and aging data. - Virtual to...

EI - Biotechnologie a bionika

  • 2017 - 2020
    • •
  • 62 149 tis. Kč
    • •
  • 62 149 tis. Kč
    • •
  • MŠMT
Project

Casein kinase 1 alpha (CK1a) inhibition as a novel therapeutic approach for AML (NW25-03-00225)

PDX model (patient-derived xenografts) in vivo. In addition, the project...

Oncology

  • 2025 - 2028
    • •
  • 14 136 tis. Kč
    • •
  • 14 136 tis. Kč
    • •
  • MZ
Project

DEVELOPMENT OF MODELS FOR THE STUDIES OF MICROENVIRONMENT AND THERAPEUTIC RESISTANCE IN B CELL MALIGNANCIES (NU23-08-00448)

and the generation of a novel patient-derived xenograft (PDX) model (AIM 2). We will also test this strategy for PDX generation in another indolent B cell malignancy, namely follicular......

Hematology

  • 2023 - 2026
    • •
  • 11 906 tis. Kč
    • •
  • 11 906 tis. Kč
    • •
  • MZ
Project

Transplantation of islets generated in vitro from stem cells of adult pancreas (NR8031)

The aim of the project is to induce the proliferation of stem cells isolated from adult rat and human pancreases and to enable them to differentiate towards the phenotype of pancreatic cells. The cell quality will be tested by means of expression of ...

FJ - Chirurgie včetně transplantologie

  • 2004 - 2006
    • •
  • 3 225 tis. Kč
    • •
  • 3 026 tis. Kč
    • •
  • MZ
Project

Intrinsic resistance to shear-mode fatigue crack growth in metallic materials (GJ17-15716Y)

experimental methodology for determination of intrinsic resistance to shear-mode fatigue in modes II and III and of the criterion for mode I branching and verification understanding of mechanisms of shear-mode cra...

JL - Únava materiálu a lomová mechanika

  • 2017 - 2018
    • •
  • 3 110 tis. Kč
    • •
  • 3 110 tis. Kč
    • •
  • GA ČR
Project

Theoretical and experimental analysis of the light propagation in magnetooptical planar and periodical structures (ME 175)

on the following areas : - mode conversion in thin films with magnetic ordering - specification of the dispersion relations for guided modes - study of linear and quadratic magnetooptic effects - application of dark mode s...

BH - Optika, masery a lasery

  • 1998 - 2001
    • •
  • 1 720 tis. Kč
    • •
  • 520 tis. Kč
    • •
  • MŠMT
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