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362 (0,13s) •

Project

The role of interactions of adaptor protein PSTPIP2 in the development of autoinflammatory disease (GA19-05076S)

inflammation via the recruitment of inhibitory molecules, including PEST-family phosphatases, SHIP1 a Csk. The mechanism of how PSTPIP2-bound molecules inhibit IL-1 beta......

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 121 tis. Kč
    • •
  • 7 593 tis. Kč
    • •
  • GA ČR
Project

Role of protein phosphatases in regulation of microtubule organization in mast cells (GA16-23702S)

activation, and inhibition of tyrosine phosphatases affects microtubule organization. Very recently we have identified tyrosine phosphatase SHP1 in γ-tubulin complexes. Involvement of phosphatases in microtubule nucleation...

EC - Imunologie

  • 2016 - 2018
    • •
  • 5 458 tis. Kč
    • •
  • 5 400 tis. Kč
    • •
  • GA ČR
Project

Regulation of extracellular phosphatase activity in different morphotypes of natural bacterioplankton studied at the single-cell level (IAA600170602)

phosphatases in natural bacterioplankton, we propose to study in parallel (1) activity of extracellular phosphatases and (2) growth and metabolic activity, both at the levelof single analysis. Extracellular phosphatase act...

DA - Hydrologie a limnologie

  • 2006 - 2008
    • •
  • 1 095 tis. Kč
    • •
  • 1 095 tis. Kč
    • •
  • AV ČR
Project

Involvement of phosphatases on CDK regulation in G2/M transition of Chlamydomonas reinhardtii cell cycle. (GPP501/10/P258)

Phosphorylation of proteins by kinases and phosphatases plays a key regulatory phosphatase activity activates the CDK-cyclin complex inhibited by Wee1 kinase. While for phosphatase activity. We propose to use model organism...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 584 tis. Kč
    • •
  • 1 584 tis. Kč
    • •
  • GA ČR
Project

Phosphorylation-mediated signalling in DNA damage response and cancer (7F14061)

In this application we will investigate the following five aims: Aim I) Molecular mechanism of PPM1D/Wip1 phosphatase function in DDR Aim II) Role of truncating PPM1D mutations in colorectal cancer Aim III) Functional role of PP1 phospha...

FD - Onkologie a hematologie

  • 2014 - 2017
    • •
  • 25 520 tis. Kč
    • •
  • 25 520 tis. Kč
    • •
  • MŠMT
Project

Study of molecular mechanisms affecting phosphatase activity of PTEN gene product (GA204/01/0488)

The PTEN is recently discovered tumor suppressor gene like p53, pRB etc., with a phosphatase activity and sequence similarity to some cytoskeletal proteins. The alterations of the PTEN were found in advanced stages of numerous human tumours,...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 1 859 tis. Kč
    • •
  • 1 859 tis. Kč
    • •
  • GA ČR
Project

Study of sensory active peptides derived from casein (GA203/96/1143)

that phosphatases may be involved in the mechanism of casein proteolysis will be verified phosphopeptides in hard an mould cheeses with relations to changes of aid phosphatase activity. The correlations between acid phosphatase...

CE - Biochemie

  • 1996 - 1998
    • •
  • 1 358 tis. Kč
    • •
  • 1 273 tis. Kč
    • •
  • GA ČR
Project

Role of protein phosphatases in telomere maintenance and ribosomal biogenesis (GA24-11257S)

established, the role phosphatases in these processes has long been neglected. Protein phosphatase PPM1D/WIP1 terminates the cell cycle checkpoints by suppressing p53 pathway......

Biochemistry and molecular biology

  • 2024 - 2026
    • •
  • 8 763 tis. Kč
    • •
  • 8 412 tis. Kč
    • •
  • GA ČR
Project

Relationship between the proteosynthesis requirements and phosphatase effects during the meiotic maturation of pig oocytes (GA505/95/1448)

9C - 9

  • 1995 - 1996
    • •
  • 126 tis. Kč
    • •
  • 126 tis. Kč
    • •
  • GA ČR
Project

FASS/TON2 functions in moss cell morphogenesis and phylogenetic insights into the TTP complex evolution (GA23-05564S)

Cell division and cell elongation orientation are major processes directing growth and development in plants constrained by cell wall. FASS/TON2 regulatory subunit of phosphatase 2A is a crucial regulator of both. We will study how its funct...

Plant sciences, botany

  • 2023 - 2025
    • •
  • 8 128 tis. Kč
    • •
  • 8 029 tis. Kč
    • •
  • GA ČR
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