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Projects

3 043 projects (0,084s) •

Project

Structural study of protein domains of monkey retrovirus (IAA4055304)

of the scaffolding protein p12 and the 13 kDa form of M-PMV protease (PR) using isotopicaly aided NMR spectroscopy. The role of the C-terminal extension of PR on its structure and higher proteolytic activity compared to th...

CE - Biochemie

  • 2003 - 2007
    • •
  • 11 354 tis. Kč
    • •
  • 4 282 tis. Kč
    • •
  • AV ČR
Project

Characterization of novel host cell protein interacting with protease of Mason-Pfizer monkey virus (GA204/09/1388)

monkey virus protease (PR) with protein of unknown cellular function, which was identified by yeast two hybrid system and named PRotease Interacting Protein (PRIP). The interaction of both proteins in cells co-tra...

EB - Genetika a molekulární biologie

  • 2009 - 2013
    • •
  • 3 130 tis. Kč
    • •
  • 3 130 tis. Kč
    • •
  • GA ČR
Project

Study of defence mechanisms of tobacco involved in resistance against viral diseases (GA522/99/1264)

of induced PR (pathogenesis-related)-proteins in tissues showing "acquired resistance", in susceptible, tolerant and resistant cultivars of tobacco. PR-proteins will be induced, characterisation, tissue and intrac...

ED - Fyziologie

  • 1999 - 2001
    • •
  • 2 347 tis. Kč
    • •
  • 1 617 tis. Kč
    • •
  • GA ČR
Project

The role of chloroplasts in mechanisms involved in replication and translation of viral-RNA in connection with host resistance (GA522/02/0708)

(coat protein CP, PR-proteins, antiviral factor AVF) of virus multiplication protein and b) to elucidate the influence of natural inhibitors of viral multiplication (CP, PR-proteins, AVF). The re...

ED - Fyziologie

  • 2002 - 2004
    • •
  • 6 030 tis. Kč
    • •
  • 2 025 tis. Kč
    • •
  • GA ČR
Project

Identification and rapid diagnosis of pathogenesis related proteins in wine (8J20AT015)

The project plans to analyze proteins in wine must and white wine, with a focus on pathogenesis-related (PR) proteins known to be associated with wine haze. A methodology of protein extraction and fractionation wil...

Biochemistry and molecular biology

  • 2020 - 2022
    • •
  • 122 tis. Kč
    • •
  • 122 tis. Kč
    • •
  • MŠMT
Project

HIV protease inhibitors mechanism of action and resistance development (GAP207/11/1798)

insertions in the PR coding region and mutations in the Gag viral protein). Finally, weThe development of potent and specific inhibitors of HIV protease (PR prolonged treatment by HIV PR inhibitors, the virus accu...

CE - Biochemie

  • 2011 - 2013
    • •
  • 5 522 tis. Kč
    • •
  • 5 522 tis. Kč
    • •
  • GA ČR
Project

Dimerisation of retroviral proteinases characterisation, structure-activity and inhibition study (GA303/98/1559)

All retroviral proteins are expressed as polyprotein precursors. Specific proteolytic cleavage by viral aspartic proteinase ( PR ) is required for the formation of mature, infectious particles. Retroviral PRs are thus an at...

CE - Biochemie

  • 1998 - 2000
    • •
  • 2 878 tis. Kč
    • •
  • 2 643 tis. Kč
    • •
  • GA ČR
Project

Signalling pathways in defence response of rape seed against serious pathogens (GA522/08/1581)

The efficiency of plant defence mechanisms against pathogens depends on the ability of the plant to recognise its effector molecules followed by signal transduction leading to the expression of PR genes. Goal of the presented project is the ...

GF - Choroby, škůdci, plevely a ochrana rostlin

  • 2008 - 2012
    • •
  • 5 362 tis. Kč
    • •
  • 5 362 tis. Kč
    • •
  • GA ČR
Project

Study of phospholipide signalling in plants (ME 506)

Study of the role of plant phospholipases in the signal transduction pathway after induction of systemic acquired resistance (SAR) in rape seed (Brassica napus). Isolation and characterization of lipid transfer proteins (LTP) from rape seed ...

CE - Biochemie

  • 2002 - 2002
    • •
  • 115 tis. Kč
    • •
  • 49 tis. Kč
    • •
  • MŠMT
Project

Protein crystallography analyses of liganded proteinase of human immunodeficiency virus ( HIV ) for design of novel anti - AIDS compounds (GV203/98/K023)

(PR). This enzyme (HIV PR) is an attractive target for chemotherapeutical rational design of alternative inhibitors acting at HIV PR regions distinct from of new inhibitors include posssible reactivity to polyprotein precu...

CF - Fyzikální chemie a teoretická chemie

  • 1998 - 2002
    • •
  • 19 820 tis. Kč
    • •
  • 16 006 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 3 043